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Theranostics 2022; 12(13):5995-6020. doi:10.7150/thno.73681 This issue Cite

Review

Emerging nanozyme-based multimodal synergistic therapies in combating bacterial infections

Yanmei Zhang1,3✉, Xin Hu1,3, Jing Shang1,3, Wenhui Shao1,3, Liming Jin1,3, Chunshan Quan1,3✉, Jun Li2✉

1. College of Life Science, Dalian Minzu University, Economical and Technological Development Zone, Dalian, 116600, China.
2. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Science, P. O. Box 110, Dalian 116023, China.
3. Key Laboratory of Biotechnology and Bioresources Utilization (Dalian Minzu University), Ministry of Education, China.

✉ Corresponding authors: E-mail: ymzhangedu.cn (Y. Zhang), mikyekenedu.cn (C. Quan); jliac.cn (J. Li).

Citation:
Zhang Y, Hu X, Shang J, Shao W, Jin L, Quan C, Li J. Emerging nanozyme-based multimodal synergistic therapies in combating bacterial infections. Theranostics 2022; 12(13):5995-6020. doi:10.7150/thno.73681. https://www.thno.org/v12p5995.htm
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Abstract

Graphic abstract

Pathogenic infections have emerged as major threats to global public health. Multidrug resistance induced by the abuse of antibiotics makes the anti-infection therapies to be a global challenge. Thus, it is urgent to develop novel, efficient and biosafe antibiotic alternatives for future antibacterial therapy. Recently, nanozymes have emerged as promising antibiotic alternatives for combating bacterial infections. More significantly, the multimodal synergistic nanozyme-based antibacterial systems open novel disinfection pathways. In this review, we are mainly focusing on the recent research progress of nanozyme-based multimodal synergistic therapies to eliminate bacterial infections. Their antibacterial mechanism, the synergistic antibacterial systems are systematically summarized and discussed according to the combination of mechanisms and the purpose to improve their antibacterial efficiency, biosafety and specificity. Finanly, the current challenges and prospects of the multimodal synergistic antibacterial systems are proposed.

Keywords: Multidrug resistance, nanozyme, peroxidase, oxidase, reactive oxygen radical, photothermal effect, selective, integrated platform, detection

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APA
Zhang, Y., Hu, X., Shang, J., Shao, W., Jin, L., Quan, C., Li, J. (2022). Emerging nanozyme-based multimodal synergistic therapies in combating bacterial infections. Theranostics, 12(13), 5995-6020. https://doi.org/10.7150/thno.73681.

ACS
Zhang, Y.; Hu, X.; Shang, J.; Shao, W.; Jin, L.; Quan, C.; Li, J. Emerging nanozyme-based multimodal synergistic therapies in combating bacterial infections. Theranostics 2022, 12 (13), 5995-6020. DOI: 10.7150/thno.73681.

NLM
Zhang Y, Hu X, Shang J, Shao W, Jin L, Quan C, Li J. Emerging nanozyme-based multimodal synergistic therapies in combating bacterial infections. Theranostics 2022; 12(13):5995-6020. doi:10.7150/thno.73681. https://www.thno.org/v12p5995.htm

CSE
Zhang Y, Hu X, Shang J, Shao W, Jin L, Quan C, Li J. 2022. Emerging nanozyme-based multimodal synergistic therapies in combating bacterial infections. Theranostics. 12(13):5995-6020.

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