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Theranostics 2024; 14(7):2946-2968. doi:10.7150/thno.95908 This issue Cite

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Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery

Junxian Cao1,4, Caifeng Li1, Zhao Cui2, Shiwen Deng1,4, Tong Lei3, Wei Liu1✉, Hongjun Yang1,2,4✉, Peng Chen1,4✉

1. Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
3. Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
4. Analysis of Complex Effects of Proprietary Chinese Medicine, Hunan Provincial Key Laboratory, Yongzhou City, Hunan Province, China.

✉ Corresponding authors: Hongjun Yang (hongjun0420sina.com); Peng Chen (chenpengac.cn); Wei Liu (lwlancerlllcom).

Citation:
Cao J, Li C, Cui Z, Deng S, Lei T, Liu W, Yang H, Chen P. Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery. Theranostics 2024; 14(7):2946-2968. doi:10.7150/thno.95908. https://www.thno.org/v14p2946.htm
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Abstract

Graphic abstract

Recent advancements in modern science have provided robust tools for drug discovery. The rapid development of transcriptome sequencing technologies has given rise to single-cell transcriptomics and single-nucleus transcriptomics, increasing the accuracy of sequencing and accelerating the drug discovery process. With the evolution of single-cell transcriptomics, spatial transcriptomics (ST) technology has emerged as a derivative approach. Spatial transcriptomics has emerged as a hot topic in the field of omics research in recent years; it not only provides information on gene expression levels but also offers spatial information on gene expression. This technology has shown tremendous potential in research on disease understanding and drug discovery. In this article, we introduce the analytical strategies of spatial transcriptomics and review its applications in novel target discovery and drug mechanism unravelling. Moreover, we discuss the current challenges and issues in this research field that need to be addressed. In conclusion, spatial transcriptomics offers a new perspective for drug discovery.

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APA
Cao, J., Li, C., Cui, Z., Deng, S., Lei, T., Liu, W., Yang, H., Chen, P. (2024). Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery. Theranostics, 14(7), 2946-2968. https://doi.org/10.7150/thno.95908.

ACS
Cao, J.; Li, C.; Cui, Z.; Deng, S.; Lei, T.; Liu, W.; Yang, H.; Chen, P. Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery. Theranostics 2024, 14 (7), 2946-2968. DOI: 10.7150/thno.95908.

NLM
Cao J, Li C, Cui Z, Deng S, Lei T, Liu W, Yang H, Chen P. Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery. Theranostics 2024; 14(7):2946-2968. doi:10.7150/thno.95908. https://www.thno.org/v14p2946.htm

CSE
Cao J, Li C, Cui Z, Deng S, Lei T, Liu W, Yang H, Chen P. 2024. Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery. Theranostics. 14(7):2946-2968.

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