Theranostics
2012; 2(3):251-257.
doi:10.7150/thno.3726 This issueCite
Research Paper
Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection
Himadri S. Mandal, Zhengding Su, Andrew Ward, Xiaowu (Shirley) Tang✉
Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada.
✉ Corresponding author: X. S. Tang, Department of Chemistry, University of Waterloo, 200 University Ave West, Waterloo, ON, Canada N2L 3G1 Email: tangxwca Phone: 519-888-4567 ext. 38037 Fax: 519-746-0435
Citation:
Mandal HS, Su Z, Ward A, Tang XS. Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection. Theranostics 2012; 2(3):251-257. doi:10.7150/thno.3726. https://www.thno.org/v02p0251.htm
Here, we report the label-free, sensitive, and real-time electrical detection of whole viruses using carbon nanotube thin film (CNT-TF) field effect devices. Selective detection of approximately 550 model viruses, M13-bacteriophage, is demonstrated using a simple two-terminal (no gate electrode) configuration. Chemical gating through specific antibody-virus binding on CNT surface is proposed to be the sensing mechanism. Compared to electrical impedance sensors with identical microelectrode dimensions (no CNT), the CNT-TF sensors exhibit sensitivity 5 orders higher. We believe the reported approach could lead to a reproducible and cost-effective solution for rapid viral identification.
Mandal, H.S., Su, Z., Ward, A., Tang, X.S. (2012). Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection. Theranostics, 2(3), 251-257. https://doi.org/10.7150/thno.3726.
ACS
Mandal, H.S.; Su, Z.; Ward, A.; Tang, X.S. Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection. Theranostics 2012, 2 (3), 251-257. DOI: 10.7150/thno.3726.
NLM
Mandal HS, Su Z, Ward A, Tang XS. Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection. Theranostics 2012; 2(3):251-257. doi:10.7150/thno.3726. https://www.thno.org/v02p0251.htm
CSE
Mandal HS, Su Z, Ward A, Tang XS. 2012. Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection. Theranostics. 2(3):251-257.