Theranostics 2012; 2(3):302-312. doi:10.7150/thno.3627


The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems

Ying Zhu1, Jing Li1, Wenxin Li1, Yu Zhang1, Xiafeng Yang1,2, Nan Chen1, Yanhong Sun1, Yun Zhao2, Chunhai Fan1, Qing Huang1 ✉

1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;
2. School of Life Sciences, Sichuan University, Sichuan 610064, China.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
Zhu Y, Li J, Li W, Zhang Y, Yang X, Chen N, Sun Y, Zhao Y, Fan C, Huang Q. The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems. Theranostics 2012; 2(3):302-312. doi:10.7150/thno.3627. Available from

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Nanodiamonds (NDs), as a new member of the carbon nanoparticles family, have attracted more and more attention in biomedicine recently due to their excellent physical and chemical properties. This paper summarizes the main results from the in vitro and in vivo safety assessments of NDs and reports the application of NDs in the development of drug delivery systems. In view of the NDs' characteristics of easy formation of a porous cluster structure in solution, an adsorption model for a variety of functional molecules on the ND clusters is proposed, which provides new ideas for developing a novel smart drug with various features such as sustained-release, targeting, and fluorescence imaging.

Keywords: Nanodiamonds (NDs), biocompatibility, drug delivery system, adsorption model, versatility.