Theranostics 2015; 5(11):1249-1263. doi:10.7150/thno.11544

Review

Magnetic Nanoparticles in Cancer Theranostics

Oliviero L. Gobbo1,2,4✉, Kristine Sjaastad3, Marek W. Radomski1,4,5, Yuri Volkov3,6, Adriele Prina-Mello3,6✉

1. School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland
2. Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland
3. Department of Clinical Medicine Trinity Centre for Health Science, St. James's Hospital, Dublin, Ireland
4. Trinity Biomedical Sciences Institute, Dublin, Ireland
5. Silesian Medical University and Kardio-Med Silesia, Zabrze, Poland
6. Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Ireland

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Citation:
Gobbo OL, Sjaastad K, Radomski MW, Volkov Y, Prina-Mello A. Magnetic Nanoparticles in Cancer Theranostics. Theranostics 2015; 5(11):1249-1263. doi:10.7150/thno.11544. Available from http://www.thno.org/v05p1249.htm

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Abstract

In a report from 2008, The International Agency for Research on Cancer predicted a tripled cancer incidence from 1975, projecting a possible 13-17 million cancer deaths worldwide by 2030. While new treatments are evolving and reaching approval for different cancer types, the main prevention of cancer mortality is through early diagnosis, detection and treatment of malignant cell growth. The last decades have seen a development of new imaging techniques now in widespread clinical use. The development of nano-imaging through fluorescent imaging and magnetic resonance imaging (MRI) has the potential to detect and diagnose cancer at an earlier stage than with current imaging methods. The characteristic properties of nanoparticles result in their theranostic potential allowing for simultaneous detection of and treatment of the disease. This review provides state of the art of the nanotechnological applications for cancer therapy. Furthermore, it advances a novel concept of personalized nanomedical theranostic therapy using iron oxide magnetic nanoparticles in conjunction with MRI imaging. Regulatory and industrial perspectives are also included to outline future perspectives in nanotechnological cancer research.

Keywords: Cancer, Magnetic nanoparticles, Drug delivery, Thermal therapy, Theranostic Nanomedicine