Bioengineering of Metal-organic Frameworks for Nanomedicine

Liu, Yuan; Zhao, Yanli; Chen, Xiaoyuan

doi:10.7150/thno.31918

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Nanotheranostics 2024; 8(4): 442-457. [Abstract] [Full text] [PDF]

Nanotheranostics 2024; 8(4): 427-441. [Abstract] [Full text] [PDF]

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Theranostics 2019; 9(11):3122-3133. doi:10.7150/thno.31918 This issue Cite

Review

Bioengineering of Metal-organic Frameworks for Nanomedicine

Yuan Liu¹, Yanli Zhao^2✉, Xiaoyuan Chen^1✉

1. Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
2. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore

Citation:

Liu Y, Zhao Y, Chen X. Bioengineering of Metal-organic Frameworks for Nanomedicine. Theranostics 2019; 9(11):3122-3133. doi:10.7150/thno.31918. https://www.thno.org/v09p3122.htm

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Abstract

Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical properties. In this review, we start with MOF as a nanocarrier for drug delivery, covering therapeutic MOF agents followed by a comprehensive discussion of surface bioengineering of MOF for improved biostability, biocompatibility, and targeted delivery. Finally, we detail the challenges and prospects of the future of MOF research for biomedical applications.

Keywords: Metal-organic frameworks, drug delivery, photodynamic therapy, surface engineering

Citation styles

APA

Liu, Y., Zhao, Y., Chen, X. (2019). Bioengineering of Metal-organic Frameworks for Nanomedicine. Theranostics, 9(11), 3122-3133. https://doi.org/10.7150/thno.31918.

ACS

Liu, Y.; Zhao, Y.; Chen, X. Bioengineering of Metal-organic Frameworks for Nanomedicine. Theranostics 2019, 9 (11), 3122-3133. DOI: 10.7150/thno.31918.

NLM

Liu Y, Zhao Y, Chen X. Bioengineering of Metal-organic Frameworks for Nanomedicine. Theranostics 2019; 9(11):3122-3133. doi:10.7150/thno.31918. https://www.thno.org/v09p3122.htm

CSE

Liu Y, Zhao Y, Chen X. 2019. Bioengineering of Metal-organic Frameworks for Nanomedicine. Theranostics. 9(11):3122-3133.

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