Full Text | PDF

Theranostics 2020; 10(22):10031-10045. doi:10.7150/thno.49008 This issue Cite

Research Paper

Bacteria responsive polyoxometalates nanocluster strategy to regulate biofilm microenvironments for enhanced synergetic antibiofilm activity and wound healing

Yuetong Zhang^1#, Yang Pi^1#, Yusheng Hua¹, Jiani Xie², Chengyan Wang², Kun Guo³, Zhigang Zhao¹, Yuan Yong^1✉

1. College of Chemistry and Environment Protection Engineering, Southwest Minzu University, Chengdu 610041, China.
2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing100040, China.
3. College of Pharmacy, Southwest Minzu University, Chengdu 610041, China.
#These authors contributed equally to this work.

✉ Corresponding author: E-mail: yongy1816com.

Abstract

Backgroud: Nowadays, biofilms that are generated as a result of antibiotic abuse cause serious threats to global public health. Such films are the primary factor that contributes to the failure of antimicrobial treatment. This is due to the fact that the films prevent antibiotic infiltration, escape from innate immune attacks by phagocytes and consequently generate bacterial resistance. Therefore, exploiting novel antibacterial agents or strategies is extremely urgent.

Methods: Herein, we report a rational construction of a novel biofilm microenvironment (BME)-responsive antibacterial platform that is based on tungsten (W)-polyoxometalate clusters (POMs) to achieve efficient bactericidal effects.

Results: On one hand, the acidity and reducibility of a BME could lead to the self-assembly of POMs to produce large aggregates, which favor biofilm accumulation and enhance photothermal conversion under near-infrared (NIR) light irradiation. On the other hand, reduced POM aggregates with BME-induced photothermal-enhanced efficiency also exhibit surprisingly high peroxidase-like activity in the catalysis of bacterial endogenous hydrogen peroxide (H₂O₂) to produce abundant reactive oxygen species (ROS). This enhances biofilm elimination and favors antibacterial effects. Most importantly, reduced POMs exhibit the optimal peroxidase-like activity in an acidic BME.

Conclusion: Therefore, in addition to providing a prospective antibacterial agent, intelligent acid/reductive dual-responsive POMs will establish a new representative paradigm for the areas of healthcare with minimal side effects.

Keywords: Biofilm, polyoxometalate, acid/reductive-responsive, peroxidase-like activity, photothermal antibacterial effect

Citation styles

©2024 Ivyspring International Publisher. Terms of use