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Theranostics 2020; 10(26):11976-11997. doi:10.7150/thno.50663 This issue Cite

Review

Novel insights into ferroptosis: Implications for age-related diseases

Ren-Peng Zhou^1,2#, Yong Chen^1#, Xin Wei¹, Bin Yu¹, Zhi-Gang Xiong², Chao Lu¹, Wei Hu^1✉

1. Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China.
2. Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
#These authors contributed equally to this work and should be considered co-first authors.

✉ Corresponding author: Prof. Wei Hu, Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China, Tel./Fax: + 86-551 63806057; E-mail: huweiedu.cn.

Abstract

Rapid increase in aging populations is an urgent problem because older adults are more likely to suffer from disabilities and age-related diseases (ARDs), burdening healthcare systems and society in general. ARDs are characterized by the progressive deterioration of tissues and organs over time, eventually leading to tissue and organ failure. To date, there are no effective interventions to prevent the progression of ARDs. Hence, there is an urgent need for new treatment strategies. Ferroptosis, an iron-dependent cell death, is linked to normal development and homeostasis. Accumulating evidence, however, has highlighted crucial roles for ferroptosis in ARDs, including neurodegenerative and cardiovascular diseases. In this review, we a) summarize initiation, regulatory mechanisms, and molecular signaling pathways involved in ferroptosis, b) discuss the direct and indirect involvement of the activation and/or inhibition of ferroptosis in the pathogenesis of some important diseases, and c) highlight therapeutic targets relevant for ARDs.

Keywords: age-related diseases, ferroptosis, lipid peroxidation, iron, reactive oxygen species

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