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Theranostics 2020; 10(5):2284-2292. doi:10.7150/thno.37429 This issue Cite

Research Paper

Association of MRI-derived radiomic biomarker with disease-free survival in patients with early-stage cervical cancer

Jin Fang^1*, Bin Zhang^1*, Shuo Wang^2,3*, Yan Jin^4*, Fei Wang^1*, Yingying Ding⁴, Qiuying Chen¹, Liting Chen¹, Yueyue Li¹, Minmin Li¹, Zhuozhi Chen¹, Lizhi Liu^5✉, Zhenyu Liu^3,6✉, Jie Tian^2,3,6✉, Shuixing Zhang^1✉

1. Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China;
2. Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine, Beihang University, Beijing, 100191, China;
3. CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China;
4. Department of Radiology, the Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Kunming, Yunnan, 650031, China;
5. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China;
6. University of Chinese Academy of Sciences, Beijing, 100080, China.
*Jin Fang, Bin Zhang, Shuo Wang, Yan Jin and Fei Wang contributed equally to this work.

✉ Corresponding authors: Lizhi Liu, M.D., Ph.D., No.651 Dongfeng East Road, Yuexiu District, Guangzhou, Guangdong, 510060, China. E-mail: liulizhorg.com; Tel: +86-20-87343217; Fax: +86-20-87342125. Zhenyu Liu, Ph.D., CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China. No.95 Zhongguancun east road, Beijing, 100190, China. Email: zhenyu.liuac.cn; Tel: +86-10-82618465; Fax: +86-10-62527995. Jie Tian, Ph.D., Fellow of AIMBE, IAMBE, IEEE, SPIE, OSA, IAPR, ISMRM, Director of the CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China. No.95 Zhongguancun east road, Beijing, 100190, China. Email: jie.tianac.cn; Tel: +86-10-82618465; Fax: +86-10-62527995. Shuixing Zhang, M.D., Ph.D., No. 613 Huangpu West Road, Tianhe District, Guangzhou, Guangdong 510630, China. E-mail: shui7515com; Tel: +86-20-38688417; Fax: +86-20-38688888. More

Abstract

Pre-treatment survival prediction plays a key role in many diseases. We aimed to determine the prognostic value of pre-treatment Magnetic Resonance Imaging (MRI) based radiomic score for disease-free survival (DFS) in patients with early-stage (IB-IIA) cervical cancer.

Methods: A total of 248 patients with early-stage cervical cancer underwent radical hysterectomy were included from two institutions between January 1, 2011 and December 31, 2017, whose MR imaging data, clinicopathological data and DFS data were collected. Patients data were randomly divided into the training cohort (n = 166) and the validation cohort (n=82). Radiomic features were extracted from the pre-treatment T2-weighted (T2w) and contrast-enhanced T1-weighted (CET1w) MR imagings for each patient. Least absolute shrinkage and selection operator (LASSO) regression and Cox proportional hazard model were applied to construct radiomic score (Rad-score). According to the cutoff of Rad-score, patients were divided into low- and high- risk groups. Pearson's correlation and Kaplan-Meier analysis were used to evaluate the association of Rad-score with DFS. A combined model incorporating Rad-score, lymph node metastasis (LNM) and lymphovascular space invasion (LVI) by multivariate Cox proportional hazard model was constructed to estimate DFS individually.

Results: Higher Rad-scores were significantly associated with worse DFS in the training and validation cohorts (P<0.001 and P=0.011, respectively). The Rad-score demonstrated better prognostic performance in estimating DFS (C-index, 0.753; 95% CI: 0.696-0.805) than the clinicopathological features (C-index, 0.632; 95% CI: 0.567-0.700). However, the combined model showed no significant improvement (C-index, 0.714; 95%CI: 0.642-0.784).

Conclusion: The results demonstrated that MRI-derived Rad-score can be used as a prognostic biomarker for patients with early-stage (IB-IIA) cervical cancer, which can facilitate clinical decision-making.

Keywords: cervical cancer, magnetic resonance imaging, radiomics, disease-free survival

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