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Volume 10 (5); 2020

Research Papers

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The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer
Wu Sun, Jialu Li, Likun Zhou, Jiayi Han, Rui Liu, Haiyang Zhang, Tao Ning, Zhiying Gao, Baorui Liu, Xi Chen, Yi Ba
Theranostics 2020; 10(5): 1981-1996. doi:10.7150/thno.37621
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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PEGylated Bilirubin-coated Iron Oxide Nanoparticles as a Biosensor for Magnetic Relaxation Switching-based ROS Detection in Whole Blood
Dong Yun Lee, Sukmo Kang, Yonghyun Lee, Jin Yong Kim, Dohyun Yoo, Wonsik Jung, Soyoung Lee, Yong Yeon Jeong, Kwangyeol Lee, Sangyong Jon
Theranostics 2020; 10(5): 1997-2007. doi:10.7150/thno.39662
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth
Celine Bouclier, Matthieu Simon, Guillaume Laconde, Morgan Pellerano, Sebastien Diot, Sylvie Lantuejoul, Benoit Busser, Laetitia Vanwonterghem, Julien Vollaire, Véronique Josserand, Baptiste Legrand, Jean-Luc Coll, Muriel Amblard, Amandine Hurbin, May C. Morris
Theranostics 2020; 10(5): 2008-2028. doi:10.7150/thno.40971
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases
Di Chen, Xinjie Zhao, Zhigang Sui, Huan Niu, Luonan Chen, Cheng Hu, Qiuhui Xuan, Xuhong Hou, Rong Zhang, Lina Zhou, Yanli Li, Huiming Yuan, Yukui Zhang, Jiarui Wu, Lihua Zhang, Ren'an Wu, Hai-Long Piao, Guowang Xu, Weiping Jia
Theranostics 2020; 10(5): 2029-2046. doi:10.7150/thno.41106
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mussel-inspired conductive Ti2C-cryogel promotes functional maturation of cardiomyocytes and enhances repair of myocardial infarction
Genlan Ye, Zubiao Wen, Feng Wen, Xiaoping Song, Leyu Wang, Chuangkun Li, Yutong He, Sugandha Prakash, Xiaozhong Qiu
Theranostics 2020; 10(5): 2047-2066. doi:10.7150/thno.38876
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer
Brittney S. Harrington, Yaowu He, Tashbib Khan, Simon Puttick, Paul J. Conroy, Thomas Kryza, Tahleesa Cuda, Kamil A Sokolowski, Brian WC Tse, Katherine K. Robbins, Buddhika J. Arachchige, Samantha J. Stehbens, Pamela M. Pollock, Sarah Reed, S. John Weroha, Paul Haluska, Carlos Salomon, Rohan Lourie, Lewis C. Perrin, Ruby H. P. Law, James C. Whisstock, John D Hooper
Theranostics 2020; 10(5): 2095-2114. doi:10.7150/thno.30736
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Comprehensive characterization of the phosphoproteome of gastric cancer from endoscopic biopsy specimens
Yuichi Abe, Hidekazu Hirano, Hirokazu Shoji, Asa Tada, Junko Isoyama, Akemi Kakudo, Daigo Gunji, Kazufumi Honda, Narikazu Boku, Jun Adachi, Takeshi Tomonaga
Theranostics 2020; 10(5): 2115-2129. doi:10.7150/thno.37623
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Glutathione-responsive disassembly of disulfide dicyanine for tumor imaging with reduction in background signal intensity
Shanyan Mo, Xiaoting Zhang, Sadaf Hameed, Yiming Zhou, Zhifei Dai
Theranostics 2020; 10(5): 2130-2140. doi:10.7150/thno.39673
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer
Qing Wang, Mengge Li, Yu Gan, Shuheng Jiang, Jie Qiao, Wei Zhang, Yingchao Fan, Yuling Shen, Yanfang Song, Zihong Meng, Ming Yao, Jianren Gu, Zhigang Zhang, Hong Tu
Theranostics 2020; 10(5): 2141-2157. doi:10.7150/thno.38704
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A mouse model of MSU-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1β as relevant therapy for gout patients
Alexandre Mariotte, Aurore De Cauwer, Chrystelle Po, Chérine Abou-Faycal, Angélique Pichot, Nicodème Paul, Ismael Aouadi, Raphael Carapito, Benoit Frisch, Cécile Macquin, Emmanuel Chatelus, Jean Sibilia, Jean-Paul Armspach, Seiamak Bahram, Philippe Georgel
Theranostics 2020; 10(5): 2158-2171. doi:10.7150/thno.40650
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Development of a high affinity Anticalin® directed against human CD98hc for theranostic applications
Friedrich-Christian Deuschle, Volker Morath, André Schiefner, Corinna Brandt, Simone Ballke, Sybille Reder, Katja Steiger, Markus Schwaiger, Wolfgang Weber, Arne Skerra
Theranostics 2020; 10(5): 2172-2187. doi:10.7150/thno.38968
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer
Hong Zhu, Yan Hu, Chenming Zeng, Linlin Chang, Fujin Ge, Weihua Wang, Fangjie Yan, Qinxin Zhao, Ji Cao, Meidan Ying, Yongchuan Gu, Lin Zheng, Qiaojun He, Bo Yang
Theranostics 2020; 10(5): 2188-2200. doi:10.7150/thno.39151
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Self-activated in vivo therapeutic cascade of erythrocyte membrane-cloaked iron-mineralized enzymes
Wen Liu, Miao-Liang Ruan, Lamei Liu, Xin Ji, Yandong Ma, Pengfei Yuan, Guoheng Tang, Hongsheng Lin, Jian Dai, Wei Xue
Theranostics 2020; 10(5): 2201-2214. doi:10.7150/thno.39621
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T
Xiongqi Han, Jianpan Huang, Anthea K.W. To, Joseph H.C. Lai, Peng Xiao, Ed X. Wu, Jiadi Xu, Kannie W.Y. Chan
Theranostics 2020; 10(5): 2215-2228. doi:10.7150/thno.40146
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Megakaryocytes promote bone formation through coupling osteogenesis with angiogenesis by secreting TGF-β1
Yong Tang, Mengjia Hu, Yang Xu, Fang Chen, Shilei Chen, Mo Chen, Yan Qi, Mingqiang Shen, Cheng Wang, Yukai Lu, Zihao Zhang, Hao Zeng, Yong Quan, Fengchao Wang, Yongping Su, Dongfeng Zeng, Song Wang, Junping Wang
Theranostics 2020; 10(5): 2229-2242. doi:10.7150/thno.40559
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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19q13 KRAB zinc-finger protein ZNF471 activates MAPK10/JNK3 signaling but is frequently silenced by promoter CpG methylation in esophageal cancer
Ran Sun, Tingxiu Xiang, Jun Tang, Weiyan Peng, Jie Luo, Lili Li, Zhu Qiu, Yiqing Tan, Lin Ye, Min Zhang, Guosheng Ren, Qian Tao
Theranostics 2020; 10(5): 2243-2259. doi:10.7150/thno.35861
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nanococktail Based on AIEgens and Semiconducting Polymers: A Single Laser Excited Image-Guided Dual Photothermal Therapy
Zi Long, Jun Dai, Qinyu Hu, Quan Wang, Shijie Zhen, Zujin Zhao, Zitong Liu, Jing-Jing Hu, Xiaoding Lou, Fan Xia
Theranostics 2020; 10(5): 2260-2272. doi:10.7150/thno.41317
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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68Ga-PSMA-HBED-CC PET/CT imaging for adenoid cystic carcinoma and salivary duct carcinoma: a phase 2 imaging study
Wim van Boxtel, Susanne Lütje, Ilse C.H. van Engen-van Grunsven, Gerald W. Verhaegh, Jack A. Schalken, Marianne A. Jonker, James Nagarajah, Martin Gotthardt, Carla M.L. van Herpen
Theranostics 2020; 10(5): 2273-2283. doi:10.7150/thno.38501
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Association of MRI-derived radiomic biomarker with disease-free survival in patients with early-stage cervical cancer
Jin Fang, Bin Zhang, Shuo Wang, Yan Jin, Fei Wang, Yingying Ding, Qiuying Chen, Liting Chen, Yueyue Li, Minmin Li, Zhuozhi Chen, Lizhi Liu, Zhenyu Liu, Jie Tian, Shuixing Zhang
Theranostics 2020; 10(5): 2284-2292. doi:10.7150/thno.37429
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism
Yin Hu, Yan Zhang, Chu-Yu Ni, Chun-Yuan Chen, Shan-Shan Rao, Hao Yin, Jie Huang, Yi-Juan Tan, Zhen-Xing Wang, Jia Cao, Zheng-Zhao Liu, Ping-Li Xie, Ben Wu, Juan Luo, Hui Xie
Theranostics 2020; 10(5): 2293-2308. doi:10.7150/thno.39238
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer
Jinglue Song, Wei Chen, Xuewei Cui, Zhenyu Huang, Dongpeng Wen, Yili Yang, Wei Yu, Long Cui, Chen-Ying Liu
Theranostics 2020; 10(5): 2327-2341. doi:10.7150/thno.39740
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury
Hui Yu, Feiyang Jin, Di Liu, Gaofeng Shu, Xiaojuan Wang, Jing Qi, Mingchen Sun, Ping Yang, Saiping Jiang, Xiaoying Ying, Yongzhong Du
Theranostics 2020; 10(5): 2342-2357. doi:10.7150/thno.40395
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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IKKε phosphorylates kindlin-2 to induce invadopodia formation and promote colorectal cancer metastasis
Ge Liu, Yantao Bao, Chaohua Liu, Qinchang Zhu, Lin Zhao, Xiaopeng Lu, Qian Zhu, Yafei Lv, Feng Bai, He Wen, Yujie Sun, Wei-Guo Zhu
Theranostics 2020; 10(5): 2358-2373. doi:10.7150/thno.40397
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cooperation therapy between anti-growth by photodynamic-AIEgens and anti-metastasis by small molecule inhibitors in ovarian cancer
Jun Dai, Min Xu, Quan Wang, Juliang Yang, Jinjin Zhang, Pengfei Cui, Wenwen Wang, Xiaoding Lou, Fan Xia, Shixuan Wang
Theranostics 2020; 10(5): 2385-2398. doi:10.7150/thno.41708
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer
Lei Zhou, Dong Wang, Dandan Sheng, Jiahui Xu, Weilong Chen, Yuanyuan Qin, Ruikai Du, Xiaoli Yang, Xueyan He, Ni Xie, Suling Liu, Lixing Zhang
Theranostics 2020; 10(5): 2405-2421. doi:10.7150/thno.38875
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CD226 deletion improves post-infarction healing via modulating macrophage polarization in mice
Jun Li, Yun Song, Jing-Yi Jin, Guo-Hua Li, Yong-Zheng Guo, Hong-Yu Yi, Jin-Rui Zhang, Ya-Jie Lu, Jing-Long Zhang, Cong-Ye Li, Chao Gao, Lu Yang, Feng Fu, Fu-lin Chen, Shu-Miao Zhang, Min Jia, Guo-Xu Zheng, Jian-Ming Pei, Li-Hua Chen
Theranostics 2020; 10(5): 2422-2435. doi:10.7150/thno.37106
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications
Nikolai G. Khlebtsov, Li Lin, Boris N. Khlebtsov, Jian Ye
Theranostics 2020; 10(5): 2067-2094. doi:10.7150/thno.39968
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis
Bairen Pang, Ying Zhu, Jie Ni, James Thompson, David Malouf, Joseph Bucci, Peter Graham, Yong Li
Theranostics 2020; 10(5): 2309-2326. doi:10.7150/thno.39486
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Refining Cancer Management Using Integrated Liquid Biopsy
Juhui Qiu, Jianxiong Xu, Kang Zhang, Wei Gu, Liming Nie, Guixue Wang, Yang Luo
Theranostics 2020; 10(5): 2374-2384. doi:10.7150/thno.40677
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging
Henriette S. de Bruijn, Vida Mashayekhi, Tom J.L. Schreurs, Pieter B.A.A. van Driel, Gustav J. Strijkers, Paul J. van Diest, Clemens W.G.M. Lowik, Ann L.B. Seynhaeve, Timo L.M. ten Hagen, Jeanine J. Prompers, Paul M.P. van Bergen en Henegouwen, Dominic J. Robinson, Sabrina Oliveira
Theranostics 2020; 10(5): 2436-2452. doi:10.7150/thno.37949
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Errata

pH-Sensitive Nano-Complexes Overcome Drug Resistance and Inhibit Metastasis of Breast Cancer by Silencing Akt Expression: Erratum
Jieying Yin, Tianqun Lang, Dongmei Cun, Zhong Zheng, Yan Huang, Qi Yin, Haijun Yu, Yaping Li
Theranostics 2020; 10(5): 2399-2400. doi:10.7150/thno.42847
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Enhanced Blood Suspensibility and Laser-Activated Tumor-specific Drug Release of Theranostic Mesoporous Silica Nanoparticles by Functionalizing with Erythrocyte Membranes: Erratum
Jinghan Su, Huiping Sun, Qingshuo Meng, Pengcheng Zhang, Qi Yin, Yaping Li
Theranostics 2020; 10(5): 2401. doi:10.7150/thno.42848
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Dual target gene therapy to EML4-ALK NSCLC by a gold nanoshell-based system: Erratum
Siwen Li, Yuxi Liu, Yalan Rui, Liping Tang, Samuel Achilefu, Yueqing Gu
Theranostics 2020; 10(5): 2402-2404. doi:10.7150/thno.43075
[Abstract] [Full text] [PDF] [PubMed] [PMC]