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Volume 10 (6); 2020

Research Papers

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Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy
Ting He, Xialing Qin, Chao Jiang, Dawei Jiang, Shan Lei, Jing Lin, Wei-Guo Zhu, Junle Qu, Peng Huang
Theranostics 2020; 10(6): 2453-2462. doi:10.7150/thno.42981
[Abstract] [Full text] [PDF]


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Sensitizing Triple Negative Breast Cancer to Tamoxifen Chemotherapy via a Redox-Responsive Vorinostat-containing Polymeric Prodrug Nanocarrier
Weina Ma, Jingjing Sun, Jieni Xu, Zhangyi Luo, Dingwei Diao, Ziqian Zhang, Patrick J. Oberly, Margaret Beth Minnigh, Wen Xie, Samuel M Poloyac, Yi Huang, Song Li
Theranostics 2020; 10(6): 2463-2478. doi:10.7150/thno.38973
[Abstract] [Full text] [PDF]


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Probing and Enhancing Ligand-Mediated Active Targeting of Tumors Using Sub-5 nm Ultrafine Iron Oxide Nanoparticles
Yaolin Xu, Hui Wu, Jing Huang, Weiping Qian, Deborah E. Martinson, Bing Ji, Yuancheng Li, Yongqiang A. Wang, Lily Yang, Hui Mao
Theranostics 2020; 10(6): 2479-2494. doi:10.7150/thno.39560
[Abstract] [Full text] [PDF]


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An intestinal model with a finger-like villus structure fabricated using a bioprinting process and collagen/SIS-based cell-laden bioink
WonJin Kim, Geun Hyung Kim
Theranostics 2020; 10(6): 2495-2508. doi:10.7150/thno.41225
[Abstract] [Full text] [PDF]


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Deep tissue photoacoustic imaging of nickel(II) dithiolene-containing polymeric nanoparticles in the second near-infrared window
Byullee Park, Kyung Min Lee, Suhyeon Park, Misun Yun, Hak-Jong Choi, Jeesu Kim, Changho Lee, Hyungwoo Kim, Chulhong Kim
Theranostics 2020; 10(6): 2509-2521. doi:10.7150/thno.39403
[Abstract] [Full text] [PDF]


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Therapeutic ultrasound combined with microbubbles improves atherosclerotic plaque stability by selectively destroying the intraplaque neovasculature
Xinzhong Li, Shengcun Guo, Tong Xu, Xiang He, Yili Sun, Xiaoqiang Chen, Shiping Cao, Xiaoyun Si, Wangjun Liao, Yulin Liao, Yuan Han, Jianping Bin
Theranostics 2020; 10(6): 2522-2537. doi:10.7150/thno.39553
[Abstract] [Full text] [PDF]


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Proteoglycan 4 predicts tribological properties of repaired cartilage tissue
Zhiguang Qiao, Mei Xin, Ling Wang, Huiwu Li, Chengtao Wang, Liao Wang, Tingting Tang, Bangshang Zhu, Gang Huang, You Wang, Minghao Zheng, Kerong Dai
Theranostics 2020; 10(6): 2538-2552. doi:10.7150/thno.39386
[Abstract] [Full text] [PDF]


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HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling
Neng Jiang, Chang Zou, Ying Zhu, Yifeng Luo, Lili Chen, Yiyan Lei, Kejing Tang, Yu Sun, Wenhui Zhang, Shuhua Li, Qiong He, Jianwen Zhou, Yangshan Chen, Jiping Luo, Wenting Jiang, Zunfu Ke
Theranostics 2020; 10(6): 2553-2570. doi:10.7150/thno.41120
[Abstract] [Full text] [PDF]


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Mitochondrial PAK6 inhibits prostate cancer cell apoptosis via the PAK6-SIRT4-ANT2 complex
Tingting Li, Yang Li, Tong Liu, Bingtao Hu, Jiabin Li, Chen Liu, Tao Liu, Feng Li
Theranostics 2020; 10(6): 2571-2586. doi:10.7150/thno.42874
[Abstract] [Full text] [PDF]


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Real-time colorectal cancer diagnosis using PR-OCT with deep learning
Yifeng Zeng, Shiqi Xu, William C. Chapman, Shuying Li, Zahra Alipour, Heba Abdelal, Deyali Chatterjee, Matthew Mutch, Quing Zhu
Theranostics 2020; 10(6): 2587-2596. doi:10.7150/thno.40099
[Abstract] [Full text] [PDF]


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Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1
Gloria Garoffolo, Matthijs S. Ruiter, Marco Piola, Maura Brioschi, Anita C. Thomas, Marco Agrifoglio, Gianluca Polvani, Lorenzo Coppadoro, Stefano Zoli, Claudio Saccu, Gaia Spinetti, Cristina Banfi, Gianfranco B. Fiore, Paolo Madeddu, Monica Soncini, Maurizio Pesce
Theranostics 2020; 10(6): 2597-2611. doi:10.7150/thno.40595
[Abstract] [Full text] [PDF]


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Targeted alpha therapy in a systemic mouse model of prostate cancer - a feasibility study
Andreea D. Stuparu, Catherine A.L. Meyer, Susan L. Evans-Axelsson, Katharina Lückerath, Liu H. Wei, Woosuk Kim, Soumya Poddar, Christine E. Mona, Magnus Dahlbom, Mark D. Girgis, Caius G. Radu, Johannes Czernin, Roger Slavik
Theranostics 2020; 10(6): 2612-2620. doi:10.7150/thno.42228
[Abstract] [Full text] [PDF]


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Evaluation of the tumor-targeting efficiency and intratumor heterogeneity of anticancer drugs using quantitative mass spectrometry imaging
Jin Zhang, Qianqian Du, Xiaowei Song, Shanshan Gao, Xuechao Pang, Yan Li, Ruiping Zhang, Zeper Abliz, Jiuming He
Theranostics 2020; 10(6): 2621-2630. doi:10.7150/thno.41763
[Abstract] [Full text] [PDF]


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Nanobody-based CD38-specific heavy chain antibodies induce killing of multiple myeloma and other hematological malignancies
Levin Schriewer, Kerstin Schütze, Katharina Petry, Julia Hambach, William Fumey, Julia Koenigsdorf, Natalie Baum, Stephan Menzel, Björn Rissiek, Kristoffer Riecken, Boris Fehse, Jana Larissa Röckendorf, Joanna Schmid, Birte Albrecht, Hans Pinnschmidt, Francis Ayuk, Nicolaus Kröger, Mascha Binder, Gunter Schuch, Timon Hansen, Friedrich Haag, Gerhard Adam, Friedrich Koch-Nolte, Peter Bannas
Theranostics 2020; 10(6): 2645-2658. doi:10.7150/thno.38533
[Abstract] [Full text] [PDF]


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Neuron labeling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain via focused ultrasound
Sophie V. Morse, Tamara Boltersdorf, Bethany I. Harriss, Tiffany G. Chan, Nicoleta Baxan, Hee Seok Jung, Antonios N. Pouliopoulos, James J. Choi, Nicholas J. Long
Theranostics 2020; 10(6): 2659-2674. doi:10.7150/thno.42665
[Abstract] [Full text] [PDF]


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Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus
Xinghui Li, Yandi Wu, Jingjing Zhao, Haiping Wang, Jing Tan, Ming Yang, Yuanlong Li, Shijie Deng, Saifei Gao, Hui Li, Zhenyu Yang, Fengmin Yang, Jianxing Ma, Jianding Cheng, Weibin Cai
Theranostics 2020; 10(6): 2675-2695. doi:10.7150/thno.40735
[Abstract] [Full text] [PDF]


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Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients
Lucilla Fabbri, Maeva Dufies, Sandra Lacas-Gervais, Betty Gardie, Sophie Gad-Lapiteau, Julien Parola, Nicolas Nottet, Monique Meyenberg Cunha de Padua, Julie Contenti, Delphine Borchiellini, Jean-Marc Ferrero, Nathalie Rioux Leclercq, Damien Ambrosetti, Baharia Mograbi, Stéphane Richard, Julien Viotti, Emmanuel Chamorey, Nirvana Sadaghianloo, Matthieu Rouleau, William J. Craigen, Bernard Mari, Stéphan Clavel, Gilles Pagès, Jacques Pouysségur, Frédéric Bost, Nathalie M. Mazure
Theranostics 2020; 10(6): 2696-2713. doi:10.7150/thno.41001
[Abstract] [Full text] [PDF]


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Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice
Fangzhao Wang, Shenhai Gong, Teng Wang, Lei Li, Haihua Luo, Junhao Wang, Chenyang Huang, Hongwei Zhou, Guiming Chen, Zhanguo Liu, Qifan Zhang, Yong Jiang, Peng Chen
Theranostics 2020; 10(6): 2714-2726. doi:10.7150/thno.40128
[Abstract] [Full text] [PDF]


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Targeting microtubule sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors
Tan-Min Chin, Gandhi T. K. Boopathy, Ellen P.S. Man, John G. Clohessy, Eva Csizmadia, Margaret P Quinlan, Thomas Putti, Seow-Ching Wan, Chen Xie, Azhar Ali, Fhu Chee Wai, Yan Shan Ong, Boon-Cher Goh, Jeff Settleman, Wanjin Hong, Elena Levantini, Daniel G. Tenen
Theranostics 2020; 10(6): 2727-2743. doi:10.7150/thno.38729
[Abstract] [Full text] [PDF]


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Oligopeptide-modified poly(beta-amino ester)s-coated AdNuPARmE1A: Boosting the efficacy of intravenously administered therapeutic adenoviruses
Pau Brugada-Vilà, Anna Cascante, Miguel Ángel Lázaro, Cristina Castells-Sala, Cristina Fornaguera, Maria Rovira-Rigau, Lorenzo Albertazzi, Salvador Borros, Cristina Fillat
Theranostics 2020; 10(6): 2744-2758. doi:10.7150/thno.40902
[Abstract] [Full text] [PDF]


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A biocompatible vascularized graphene oxide (GO)-collagen chamber with osteoinductive and anti-fibrosis effects promotes bone regeneration in vivo
Huimin Fang, Chao Luo, Shaokai Liu, Muran Zhou, Yuyang Zeng, Jinfei Hou, Lifeng Chen, Shan Mou, Jiaming Sun, Zhenxing Wang
Theranostics 2020; 10(6): 2759-2772. doi:10.7150/thno.42006
[Abstract] [Full text] [PDF]


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Inflammatory extracellular vesicles prompt heart dysfunction via TRL4-dependent NF-κB activation
Vanessa Biemmi, Giuseppina Milano, Alessandra Ciullo, Elisabetta Cervio, Jacopo Burrello, Michele Dei Cas, Rita Paroni, Tiziano Tallone, Tiziano Moccetti, Giovanni Pedrazzini, Sarah Longnus, Giuseppe Vassalli, Lucio Barile
Theranostics 2020; 10(6): 2773-2790. doi:10.7150/thno.39072
[Abstract] [Full text] [PDF]


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LDH-stabilized ultrasmall iron oxide nanoparticles as a platform for hyaluronidase-promoted MR imaging and chemotherapy of tumors
Ni Zhang, Yue Wang, Changchang Zhang, Yu Fan, Du Li, Xueyan Cao, Jindong Xia, Xiangyang Shi, Rui Guo
Theranostics 2020; 10(6): 2791-2802. doi:10.7150/thno.42906
[Abstract] [Full text] [PDF]


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Dysbiosis of intestinal microbiota mediates tubulointerstitial injury in diabetic nephropathy via the disruption of cholesterol homeostasis
Ze Bo Hu, Jian Lu, Pei Pei Chen, Chen Chen Lu, Jia Xiu Zhang, Xue Qi Li, Ben Yin Yuan, Si Jia Huang, Xiong Zhong Ruan, Bi Cheng Liu, Kun Ling Ma
Theranostics 2020; 10(6): 2803-2816. doi:10.7150/thno.40571
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FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells
Chia-Wei Huang, Shih-Yu Lu, Tzu-Chieh Huang, Bu-Miim Huang, H. Sunny Sun, Shang-Hsun Yang, Jih-Ing Chuang, Yuan-Yu Hsueh, Yi-Ting Wu, Chia-Ching Wu
Theranostics 2020; 10(6): 2817-2831. doi:10.7150/thno.38553
[Abstract] [Full text] [PDF]


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Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion
Bin Han, Wei Jiang, Haijie Liu, Junjie Wang, Kai Zheng, Pan Cui, Yan Feng, Chun Dang, Yali Bu, Qing Mei Wang, Zhenyu Ju, Junwei Hao
Theranostics 2020; 10(6): 2832-2848. doi:10.7150/thno.37119
[Abstract] [Full text] [PDF]


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Localized anesthesia of a specific brain region using ultrasound-responsive barbiturate nanodroplets
Harriet Lea-Banks, Meaghan A. O'Reilly, Clement Hamani, Kullervo Hynynen
Theranostics 2020; 10(6): 2849-2858. doi:10.7150/thno.41566
[Abstract] [Full text] [PDF]


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FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity
Wei Wu, Doudou Jing, Zibo Meng, Binwu Hu, Binlong Zhong, Xiangyu Deng, Xin Jin, Zengwu Shao
Theranostics 2020; 10(6): 2859-2871. doi:10.7150/thno.41279
[Abstract] [Full text] [PDF]


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Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis
Xiongfa Ji, Zehua Lei, Meng Yuan, Hao Zhu, Xi Yuan, Wenbin Liu, Hongxu Pu, Jiawei Jiang, Yu Zhang, Xulin Jiang, Jun Xiao
Theranostics 2020; 10(6): 2872-2887. doi:10.7150/thno.41622
[Abstract] [Full text] [PDF]

Review

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Near-IR emissive rare-earth nanoparticles for guided surgery
Zhibei Qu, Jianlei Shen, Qian Li, Feng Xu, Fei Wang, Xueli Zhang, Chunhai Fan
Theranostics 2020; 10(6): 2631-2644. doi:10.7150/thno.40808
[Abstract] [Full text] [PDF]