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Volume 10 (4); 2020

Research Papers

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Ultrasmall CuS@BSA nanoparticles with mild photothermal conversion synergistically induce MSCs-differentiated fibroblast and improve skin regeneration
Yao Xiao, Jinrong Peng, Qingya Liu, Lijuan Chen, Kun Shi, Ruxia Han, Qian Yang, Lin Zhong, Ruoyu Zha, Ying Qu, Zhiyong Qian
Theranostics 2020; 10(4): 1500-1513. doi:10.7150/thno.39471
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Effect of Cardiogenic Factors on Cardiac Mesenchymal Cell Anti-Fibrogenic Paracrine Signaling and Therapeutic Performance
Justin S. Heidel, Annalara G. Fischer, Xian-Liang Tang, Ghazal Sadri, Wen-Jian Wu, Claudiu R. Moisa, Heather Stowers, Neel Sandella, Marcin Wysoczynski, Shizuka Uchida, Joseph B. Moore IV
Theranostics 2020; 10(4): 1514-1530. doi:10.7150/thno.41000
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts
Florence Coussy, Marion Lavigne, Leanne de Koning, Rania El Botty, Fariba Nemati, Adnan Naguez, Guillaume Bataillon, Berengère Ouine, Ahmed Dahmani, Elodie Montaudon, Pierre Painsec, Sophie Chateau-Joubert, Fuhrmann Laetitia, Thibaut Larcher, Sophie Vacher, Walid Chemlali, Adrien Briaux, Samia Melaabi, Anne Vincent Salomon, Jean Marc Guinebretiere, Ivan Bieche, Elisabetta Marangoni
Theranostics 2020; 10(4): 1531-1543. doi:10.7150/thno.36182
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Glucose Oxidase-Instructed Traceable Self-Oxygenation/Hyperthermia Dually Enhanced Cancer Starvation Therapy
Ting He, Han Xu, Yifan Zhang, Shijian Yi, Run Cui, Shaojun Xing, Chaoliang Wei, Jing Lin, Peng Huang
Theranostics 2020; 10(4): 1544-1554. doi:10.7150/thno.40439
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Therapeutic targeting of YY1/MZF1 axis by MZF1-uPEP inhibits aerobic glycolysis and neuroblastoma progression
Erhu Fang, Xiaojing Wang, Jianqun Wang, Anpei Hu, Huajie Song, Feng Yang, Dan Li, Wenjing Xiao, Yajun Chen, Yanhua Guo, Yang Liu, Hongjun Li, Kai Huang, Liduan Zheng, Qiangsong Tong
Theranostics 2020; 10(4): 1555-1571. doi:10.7150/thno.37383
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A bioceramic scaffold composed of strontium-doped three-dimensional hydroxyapatite whiskers for enhanced bone regeneration in osteoporotic defects
Rui Zhao, Siyu Chen, Wanlu Zhao, Long Yang, Bo Yuan, Voicu Stefan Ioan, Antoniac Vasile Iulian, Xiao Yang, Xiangdong Zhu, Xingdong Zhang
Theranostics 2020; 10(4): 1572-1589. doi:10.7150/thno.40103
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rats
Feng Rao, Yanhua Wang, Dianying Zhang, Changfeng Lu, Zheng Cao, Jiajie Sui, Mengjiao Wu, Yawen Zhang, Wei Pi, Bo Wang, Yuhui Kou, Xiumei Wang, Peixun Zhang, Baoguo Jiang
Theranostics 2020; 10(4): 1590-1603. doi:10.7150/thno.36272
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure
Dallan McMahon, Wendy Oakden, Kullervo Hynynen
Theranostics 2020; 10(4): 1604-1618. doi:10.7150/thno.40908
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer
Jiyuan Chen, Zhenjie Wu, Weihong Ding, Chengwu Xiao, Yu Zhang, Shen Gao, Yuan Gao, Weimin Cai
Theranostics 2020; 10(4): 1619-1632. doi:10.7150/thno.40489
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Gold nanoclusters elicit homeostatic perturbations in glioblastoma cells and adaptive changes of lysosomes
Dusica Maysinger, Evan R. Gran, Franck Bertorelle, Hussein Fakhouri, Rodolphe Antoine, Esha S. Kaul, Dana M. Samhadaneh, Ursula Stochaj
Theranostics 2020; 10(4): 1633-1648. doi:10.7150/thno.37674
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration
Rui Li, Duohui Li, Chengbiao Wu, Libing Ye, Yanqing Wu, Yuan Yuan, Shengnan Yang, Ling Xie, Yuqin Mao, Ting Jiang, Yiyang Li, Jian Wang, Hongyu Zhang, Xiaokun Li, Jian Xiao
Theranostics 2020; 10(4): 1649-1677. doi:10.7150/thno.40919
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Development of a new class of PSMA radioligands comprising ibuprofen as an albumin-binding entity
Luisa M. Deberle, Martina Benešová, Christoph A. Umbricht, Francesca Borgna, Manuel Büchler, Konstantin Zhernosekov, Roger Schibli, Cristina Müller
Theranostics 2020; 10(4): 1678-1693. doi:10.7150/thno.40482
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Sex Differences Revealed in a Mouse CFA Inflammation Model with Macrophage Targeted Nanotheranostics
Lu Liu, Huseyin Karagoz, Michele Herneisey, Fatih Zor, Takaaki Komatsu, Shannon Loftus, Bratislav M. Janjic, Vijay S. Gorantla, Jelena M. Janjic
Theranostics 2020; 10(4): 1694-1707. doi:10.7150/thno.41309
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex
Shifeng Li, Zhongqiu Wei, Gengxu Li, Qiaodan Zhang, Siyu Niu, Dingjie Xu, Na Mao, Si Chen, Xuemin Gao, Wenchen Cai, Ying Zhu, Guizhen Zhang, Dan Li, Xue Yi, Fang Yang, Hong Xu
Theranostics 2020; 10(4): 1719-1732. doi:10.7150/thno.37049
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Imaging the Landmarks of Vascular Recovery
Jamila Hedhli, MinWoo Kim, Hailey J. Knox, John A. Cole, Than Huynh, Matthew Schuelke, Iwona T. Dobrucki, Leszek Kalinowski, Jefferson Chan, Albert J. Sinusas, Michael F. Insana, Lawrence W. Dobrucki
Theranostics 2020; 10(4): 1733-1745. doi:10.7150/thno.36022
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Influence of Glycans-Specific Bioconjugation on the FcγRI Binding and In vivo Performance of 89Zr-DFO-Pertuzumab
Delphine Vivier, Kimberly Fung, Cindy Rodriguez, Pierre Adumeau, Gary A. Ulaner, Jason S. Lewis, Sai Kiran Sharma, Brian M. Zeglis
Theranostics 2020; 10(4): 1746-1757. doi:10.7150/thno.39089
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis
Chaohua Liu, Qiaoyan Yang, Qian Zhu, Xiaopeng Lu, Meiting Li, Tianyun Hou, Zhiming Li, Ming Tang, Yinglu Li, Hui Wang, Yang Yang, Haiying Wang, Ying Zhao, He Wen, Xiangyu Liu, Zebin Mao, Wei-Guo Zhu
Theranostics 2020; 10(4): 1758-1776. doi:10.7150/thno.39013
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Novel ESCC-related gene ZNF750 as potential Prognostic biomarker and inhibits Epithelial-Mesenchymal Transition through directly depressing SNAI1 promoter in ESCC
Pengzhou Kong, Enwei Xu, Yanghui Bi, Xiaoqin Xu, Xue Liu, Bin Song, Ling Zhang, Caixia Cheng, Ting Yan, Yu Qian, Jian Yang, Yanchun Ma, Heyang Cui, Yuanfang Zhai, Binbin Zou, Xiangchen Liu, Yikun Cheng, Shiping Guo, Xiaolong Cheng, Yongping Cui
Theranostics 2020; 10(4): 1798-1813. doi:10.7150/thno.38210
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Neutrophil infiltration and whole-cell vaccine elicited by N-dihydrogalactochitosan combined with NIR phototherapy to enhance antitumor immune response and T cell immune memory
Shuhong Qi, Lisen Lu, Feifan Zhou, Yuzhou Chen, Mengli Xu, Lu Chen, Xiang Yu, Wei R. Chen, Zhihong Zhang
Theranostics 2020; 10(4): 1814-1832. doi:10.7150/thno.38515
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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UCH-L1-mediated Down-regulation of Estrogen Receptor α Contributes to Insensitivity to Endocrine Therapy for Breast Cancer
Xi-Sha Chen, Kuan-Song Wang, Wei Guo, Lan-Ya Li, Pian Yu, Xin-Yuan Sun, Hai-Yan Wang, Yi-Di Guan, Yong-Guang Tao, Bo-Ni Ding, Ming-Zhu Yin, Xing-Cong Ren, Yi Zhang, Ce-Shi Chen, Yuan-Chao Ye, Jin-Ming Yang, Yan Cheng
Theranostics 2020; 10(4): 1833-1848. doi:10.7150/thno.39814
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Label-free whole-colony imaging and metabolic analysis of metastatic pancreatic cancer by an autoregulating flexible optical system
Binglin Shen, Junshuai Yan, Shiqi Wang, Feifan Zhou, Yihua Zhao, Rui Hu, Junle Qu, Liwei Liu
Theranostics 2020; 10(4): 1849-1860. doi:10.7150/thno.40869
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Coordination-induced exfoliation to monolayer Bi-anchored MnB2 nanosheets for multimodal imaging-guided photothermal therapy of cancer
Zhaokui Jin, Danyang Chen, Penghe Zhao, Yanyuan Wen, Mingjian Fan, Gaoxin Zhou, Yingshuai Wang, Qianjun He
Theranostics 2020; 10(4): 1861-1872. doi:10.7150/thno.39715
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Monitoring innate immune cell dynamics in the glioma microenvironment by magnetic resonance imaging and multiphoton microscopy (MR-MPM)
Kianush Karimian-Jazi, Philipp Münch, Allen Alexander, Manuel Fischer, Kira Pfleiderer, Manuel Piechutta, Matthia A. Karreman, Gergely M. Solecki, Anna S. Berghoff, Mirco Friedrich, Katrin Deumelandt, Felix T. Kurz, Wolfgang Wick, Sabine Heiland, Martin Bendszus, Frank Winkler, Michael Platten, Michael O. Breckwoldt
Theranostics 2020; 10(4): 1873-1883. doi:10.7150/thno.38659
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity
Myrofora Panagi, Chrysovalantis Voutouri, Fotios Mpekris, Panagiotis Papageorgis, Margaret R Martin, John D Martin, Philippos Demetriou, Chryso Pierides, Christiana Polydorou, Andreas Stylianou, Maria Louca, Laura Koumas, Paul Costeas, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Theranostics 2020; 10(4): 1910-1922. doi:10.7150/thno.36936
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Multimodal and multiscale optical imaging of nanomedicine delivery across the blood-brain barrier upon sonopermeation
Jan-Niklas May, Susanne K. Golombek, Maike Baues, Anshuman Dasgupta, Natascha Drude, Anne Rix, Dirk Rommel, Saskia von Stillfried, Lia Appold, Robert Pola, Michal Pechar, Louis van Bloois, Gert Storm, Alexander J. C. Kuehne, Felix Gremse, Benjamin Theek, Fabian Kiessling, Twan Lammers
Theranostics 2020; 10(4): 1948-1959. doi:10.7150/thno.41161
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Re-recognition of pseudogenes: From molecular to clinical applications
Xu Chen, Lin Wan, Wei Wang, Wen-Jin Xi, An-Gang Yang, Tao Wang
Theranostics 2020; 10(4): 1479-1499. doi:10.7150/thno.40659
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Molecular imaging biomarkers for immune checkpoint inhibitor therapy
Pim P van de Donk, Laura Kist de Ruijter, Marjolijn N Lub-de Hooge, Adrienne H Brouwers, Anthonie J van der Wekken, Sjoukje F Oosting, Rudolf SN Fehrmann, Derk Jan A de Groot, Elisabeth GE de Vries
Theranostics 2020; 10(4): 1708-1718. doi:10.7150/thno.38339
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The “ART” of Epigenetics in Melanoma: From histone “Alterations, to Resistance and Therapies”
Thomas Strub, Robert Ballotti, Corine Bertolotto
Theranostics 2020; 10(4): 1777-1797. doi:10.7150/thno.36218
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment
Josanne Sophia de Maar, Alexandros Marios Sofias, Tiffany Porta Siegel, Rob J. Vreeken, Chrit Moonen, Clemens Bos, Roel Deckers
Theranostics 2020; 10(4): 1884-1909. doi:10.7150/thno.38625
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nanoparticle-based Cell Trackers for Biomedical Applications
Jen-Shyang Ni, Yaxi Li, Wentong Yue, Bin Liu, Kai Li
Theranostics 2020; 10(4): 1923-1947. doi:10.7150/thno.39915
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Towards extracellular matrix normalization for improved treatment of solid tumors
Hoda Soleymani Abyaneh, Maximilian Regenold, Trevor D. McKee, Christine Allen, Marc A. Gauthier
Theranostics 2020; 10(4): 1960-1980. doi:10.7150/thno.39995
[Abstract] [Full text] [PDF] [PubMed] [PMC]