Theranostics 2020; 10(10):4606-4613. doi:10.7150/thno.45016

Research Paper

CT Scans of Patients with 2019 Novel Coronavirus (COVID-19) Pneumonia

Wei Zhao1*, Zheng Zhong3,4*, Xingzhi Xie1, Qizhi Yu3,4✉, Jun Liu1,2✉

1. Department of Radiology, The Second Xiangya Hospital, Central South University, No.139 Middle Remin Road, Changsha, Hunan, 410011, P.R. China.
2. Department of Radiology Quality Control Center, Changsha, Hunan Province, 410011, China.
3. Department of Radiology, First Hospital of Changsha, Hunan Province, 410005, China.
4. Changsha Public Health Treatment Center, Hunan Province, 410153, China.
*Equal contributions to this work.

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Citation:
Zhao W, Zhong Z, Xie X, Yu Q, Liu J. CT Scans of Patients with 2019 Novel Coronavirus (COVID-19) Pneumonia. Theranostics 2020; 10(10):4606-4613. doi:10.7150/thno.45016. Available from http://www.thno.org/v10p4606.htm

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Abstract

Rationale: The increasing speed of confirmed 2019 novel coronavirus (COVID-19) cases is striking in China. The purpose of this study is to summarize the outcomes of patients with novel COVID-19 pneumonia (NCP) at our institution.

Methods: In this single-center study, we retrospectively included 118 cases of NCP, from January 16, 2020 to February 4, 2020. The clinical outcomes were monitored up to February 11, 2020. The outcomes of NCP patients were phase summarized at our institution. Three kinds of responses to clinical treatment were defined and evaluated: 1) good, symptoms continually improved; 2) fair, symptoms not improved or relapsed; 3) poor, symptoms aggravated. The risk factors, including basal clinical characteristics, CT imaging features, and follow-up CT changes (no change, progress, and improvement) related to poor/fair outcomes, were also investigated.

Results: Six patients were improved to no-emergency type, 2 remained the same, and 2 progressed to fatal type. Besides, 13 patients progressed from the common type group to the emergency group (3 in fatal type and 10 in severe type). Forty-two (35.6%) patients were discharged with a median hospital stay of 9.5 days (range, 4.0-15.0 days). Thus, the numbers in different responses were, 73 patients in good response group (4 emergency cases, 69 no-emergency cases), 28 in fair response group (3 emergency cases, 25 no-emergency cases), and 17 in poor response group (3 emergency cases, 14 no-emergency cases). No patient has died in our hospital to date. The median duration of progress observed from CT scans was 6 days (range, 2-14 days). The progression in abnormal imaging findings indicate a poor/fair response, whereas the alleviated symptoms seen from CT suggest a good response.

Conclusion: Most cases are no-emergency type and have a favorable response to clinical treatment. Follow-up CT changes during the treatment can help evaluate the treatment response of patients with NCP.

Keywords: COVID-19 pneumonia, CT scan, follow up, treatment response