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Volume 10 (10); 2020

Research Papers

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SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression
Zhijie Zhang, Ni Qiu, Jiang Yin, Jianlei Zhang, Hao Liu, Wei Guo, Meijun Liu, Ting Liu, Danyang Chen, Kai Luo, Hongsheng Li, Zhimin He, Jinbao Liu, Guopei Zheng
Theranostics 2020; 10(10): 4290-4307. doi:10.7150/thno.41008
[Abstract] [Full text] [PDF]


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Muscone/RI7217 co-modified upward messenger DTX liposomes enhanced permeability of blood-brain barrier and targeting glioma
Shuangming Kang, Wenjuan Duan, Shangqian Zhang, Dawei Chen, Jianfang Feng, Na Qi
Theranostics 2020; 10(10): 4308-4322. doi:10.7150/thno.41322
[Abstract] [Full text] [PDF]


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Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma
Huan Lu, Yuan Liang, Bao Guan, Yue Shi, Yanqing Gong, Juan Li, Wenwen Kong, Jin Liu, Dong Fang, Libo Liu, Qun He, Muhammad Shakeel, Xuesong Li, Liqun Zhou, Weimin Ci
Theranostics 2020; 10(10): 4323-4333. doi:10.7150/thno.43251
[Abstract] [Full text] [PDF]


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miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss
Gengyang Shen, Hui Ren, Qi Shang, Zhida Zhang, Wenhua Zhao, Xiang Yu, Jingjing Tang, Zhidong Yang, De Liang, Xiaobing Jiang
Theranostics 2020; 10(10): 4334-4348. doi:10.7150/thno.42982
[Abstract] [Full text] [PDF]


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Multifunctional PVCL nanogels with redox-responsiveness enable enhanced MR imaging and ultrasound-promoted tumor chemotherapy
Fang Xu, Jianzhi Zhu, Lizhou Lin, Changchang Zhang, Wenjie Sun, Yu Fan, Fangfang Yin, Jan C. M. van Hest, Han Wang, Lianfang Du, Xiangyang Shi
Theranostics 2020; 10(10): 4349-4358. doi:10.7150/thno.43402
[Abstract] [Full text] [PDF]


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The molecular landscape and microenvironment of salivary duct carcinoma reveal new therapeutic opportunities
Melissa Alame, Emmanuel Cornillot, Valère Cacheux, Guillaume Tosato, Marion Four, Laura De Oliveira, Stéphanie Gofflot, Philippe Delvenne, Evgenia Turtoi, Simon Cabello-Aguilar, Masahiko Nishiyama, Andrei Turtoi, Valérie Costes-Martineau, Jacques Colinge
Theranostics 2020; 10(10): 4383-4394. doi:10.7150/thno.42986
[Abstract] [Full text] [PDF]


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circPRRC2A promotes angiogenesis and metastasis through epithelial-mesenchymal transition and upregulates TRPM3 in renal cell carcinoma
Wei Li, Feng-Qiang Yang, Chen-Min Sun, Jian-Hua Huang, Hai-Min Zhang, Xue Li, Guang-Chun Wang, Ning Zhang, Jian-Ping Che, Wen-Tao Zhang, Yang Yan, Xu-Dong Yao, Bo Peng, Jun-Hua Zheng, Min Liu
Theranostics 2020; 10(10): 4395-4409. doi:10.7150/thno.43239
[Abstract] [Full text] [PDF]


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Nondestructive analysis of tumor-associated membrane protein MUC1 in living cells based on dual-terminal amplification of a DNA ternary complex
Xiaohao Liu, Dongsheng Mao, Guoli Deng, Yuchen Song, Fan Zhang, Shiqi Yang, Genxi Li, Feng Liu, Wei Cao, Xiaoli Zhu
Theranostics 2020; 10(10): 4410-4421. doi:10.7150/thno.42951
[Abstract] [Full text] [PDF]


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The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy
Qiang Guo, Meiyu Quan, Jinglai Dong, Jing Bai, Jie Wang, Rui Han, Wei Wang, Yaxin Cai, Yu-Qing Lv, Qianjie Chen, Huijing Xu, Han-Deng Lyu, Liancheng Deng, Depu Zhou, Xueyuan Xiao, Stijn De Langhe, Daniel D. Billadeau, Zhenkun Lou, Jin-San Zhang
Theranostics 2020; 10(10): 4422-4436. doi:10.7150/thno.42795
[Abstract] [Full text] [PDF]


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PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression
Ming Liu, Bing Yao, Tao Gui, Chan Guo, Xiaobin Wu, Jiahuang Li, Lingling Ma, Yexuan Deng, Peipei Xu, Ying Wang, Dongjun Yang, Qixiang Li, Xiangwei Zeng, Xinyu Li, Ruifeng Hu, Jingru Ge, Zenong Yu, Yugen Chen, Bing Chen, Junyi Ju, Quan Zhao
Theranostics 2020; 10(10): 4437-4452. doi:10.7150/thno.42047
[Abstract] [Full text] [PDF]


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PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury
Zhengze Xue, Yu Zhang, Yuanxing Liu, Cheng Zhang, Xiu-da Shen, Feng Gao, Ronald W. Busuttil, Shusen Zheng, Jerzy W. Kupiec-Weglinski, Haofeng Ji
Theranostics 2020; 10(10): 4453-4465. doi:10.7150/thno.42354
[Abstract] [Full text] [PDF]


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SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy
Weitao Shen, Wei Zhang, Weilin Ye, Haihong Wang, Qingxi Zhang, Jie Shen, Qingsha Hong, Xiang Li, Ge Wen, Ting Wei, Jian Zhang
Theranostics 2020; 10(10): 4466-4480. doi:10.7150/thno.42478
[Abstract] [Full text] [PDF]


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Human CD8 T cells are susceptible to TNF-mediated activation-induced cell death
Itziar Otano, Maite Alvarez, Luna Minute, María Carmen Ochoa, Itziar Migueliz, Carmen Molina, Arantza Azpilikueta, Carlos E. de Andrea, Iñaki Etxeberria, Miguel F. Sanmamed, Álvaro Teijeira, Pedro Berraondo, Ignacio Melero
Theranostics 2020; 10(10): 4481-4489. doi:10.7150/thno.41646
[Abstract] [Full text] [PDF]


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Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (NIS) gene expression using a heat-inducible gene promoter in engineered mesenchymal stem cells
Mariella Tutter, Christina Schug, Kathrin A. Schmohl, Sarah Urnauer, Nathalie Schwenk, Matteo Petrini, Wouter J. M. Lokerse, Christian Zach, Sibylle Ziegler, Peter Bartenstein, Wolfgang A. Weber, Ernst Wagner, Lars H. Lindner, Peter J. Nelson, Christine Spitzweg
Theranostics 2020; 10(10): 4490-4506. doi:10.7150/thno.41489
[Abstract] [Full text] [PDF]


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Glucose oxidase-like activity of cerium oxide nanoparticles: use for personal glucose meter-based label-free target DNA detection
Hyo Yong Kim, Ki Soo Park, Hyun Gyu Park
Theranostics 2020; 10(10): 4507-4514. doi:10.7150/thno.41484
[Abstract] [Full text] [PDF]


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G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome
Francesco Casciello, Fares Al-Ejeh, Mariska Miranda, Greg Kelly, Eva Baxter, Karolina Windloch, Frank Gannon, Jason S Lee
Theranostics 2020; 10(10): 4515-4529. doi:10.7150/thno.41453
[Abstract] [Full text] [PDF]


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A dual-functional Embolization-Visualization System for Fluorescence image-guided Tumor Resection
M. Martin Jensen, Zachary B. Barber, Nitish Khurana, Kyle J. Isaacson, Douglas Steinhauff, Bryant Green, Joseph Cappello, Abigail Pulsipher, Hamidreza Ghandehari, Jeremiah A. Alt
Theranostics 2020; 10(10): 4530-4543. doi:10.7150/thno.39700
[Abstract] [Full text] [PDF]


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Carbon black nanoparticles induce cell necrosis through lysosomal membrane permeabilization and cause subsequent inflammatory response
Xia Yuan, Wen Nie, Zhiyao He, Jingyun Yang, Bin Shao, Xuelei Ma, Xiangxian Zhang, Zhenfei Bi, Lu Sun, Xiao Liang, Yan Tie, Yu Liu, Fei Mo, Dan Xie, Yuquan Wei, Xiawei Wei
Theranostics 2020; 10(10): 4589-4605. doi:10.7150/thno.34065
[Abstract] [Full text] [PDF]


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CT Scans of Patients with 2019 Novel Coronavirus (COVID-19) Pneumonia
Wei Zhao, Zheng Zhong, Xingzhi Xie, Qizhi Yu, Jun Liu
Theranostics 2020; 10(10): 4606-4613. doi:10.7150/thno.45016
[Abstract] [Full text] [PDF]


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Noninvasive Young's modulus visualization of fibrosis progression and delineation of pancreatic ductal adenocarcinoma (PDAC) tumors using Harmonic Motion Elastography (HME) in vivo
Alireza Nabavizadeh, Thomas Payen, Alina C. Iuga, Irina R. Sagalovskiy, Deborah Desrouilleres, Niloufar Saharkhiz, Carmine F. Palermo, Stephen A. Sastra, Paul E. Oberstein, Vilma Rosario, Michael D. Kluger, Beth A. Schrope, John A. Chabot, Kenneth P. Olive, Elisa E. Konofagou
Theranostics 2020; 10(10): 4614-4626. doi:10.7150/thno.37965
[Abstract] [Full text] [PDF]


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SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway
Chenhao Zhou, Chunxiao Liu, Wenjie Liu, Wanyong Chen, Yirui Yin, Chia-Wei Li, Jennifer L. Hsu, Jialei Sun, Qiang Zhou, Hui Li, Bo Hu, Peiyao Fu, Manar Atyah, Qianni Ma, Yang Xu, Qiongzhu Dong, Mien-Chie Hung, Ning Ren
Theranostics 2020; 10(10): 4627-4643. doi:10.7150/thno.42869
[Abstract] [Full text] [PDF]


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Nuclear translocation of PLSCR1 activates STAT1 signaling in basal-like breast cancer
Panpan Huang, Ruocen Liao, Xingyu Chen, Xuebiao Wu, Xiaoli Li, Yifan Wang, Qianhua Cao, Chenfang Dong
Theranostics 2020; 10(10): 4644-4658. doi:10.7150/thno.43150
[Abstract] [Full text] [PDF]


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Tumor reoxygenation for enhanced combination of radiation therapy and microwave thermal therapy using oxygen generation in situ by CuO nanosuperparticles under microwave irradiation
Zengzhen Chen, Wenna Guo, Qiong Wu, Longfei Tan, Tengchuang Ma, Changhui Fu, Jie Yu, Xiangling Ren, Jianming Wang, Ping Liang, Xianwei Meng
Theranostics 2020; 10(10): 4659-4675. doi:10.7150/thno.42818
[Abstract] [Full text] [PDF]


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Real-time and multimodality image-guided intelligent HIFU therapy for uterine fibroid
Guochen Ning, Xinran Zhang, Qin Zhang, Zhibiao Wang, Hongen Liao
Theranostics 2020; 10(10): 4676-4693. doi:10.7150/thno.42830
[Abstract] [Full text] [PDF]


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In vivo assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging
Zhihua Xie, Yanqing Yang, Yaqiong He, Chengyou Shu, Dong Chen, Jinke Zhang, Jingqin Chen, Chengbo Liu, Zonghai Sheng, Huadong Liu, Jie Liu, Xiaojing Gong, Liang Song, Shaohong Dong
Theranostics 2020; 10(10): 4694-4704. doi:10.7150/thno.41211
[Abstract] [Full text] [PDF]


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Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis
Yanjun Liu, Hongtao Liu, Yi Li, Rui Mao, Huawu Yang, Yuanchuan Zhang, Yu Zhang, Pengsen Guo, Dafang Zhan, Tongtong Zhang
Theranostics 2020; 10(10): 4705-4719. doi:10.7150/thno.42417
[Abstract] [Full text] [PDF]

Reviews

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Signal amplification and quantification on lateral flow assays by laser excitation of plasmonic nanomaterials
Haihang Ye, Yaning Liu, Li Zhan, Yilin Liu, Zhenpeng Qin
Theranostics 2020; 10(10): 4359-4373. doi:10.7150/thno.44298
[Abstract] [Full text] [PDF]


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Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases
Shao-Shuai Wu, Qing-Cui Li, Chang-Qing Yin, Wen Xue, Chun-Qing Song
Theranostics 2020; 10(10): 4374-4382. doi:10.7150/thno.43360
[Abstract] [Full text] [PDF]


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Tumor circulome in the liquid biopsies for cancer diagnosis and prognosis
Jicheng Wu, Shen Hu, Lihong Zhang, Jinxia Xin, Chongran Sun, Liquan Wang, Kefeng Ding, Ben Wang
Theranostics 2020; 10(10): 4544-4556. doi:10.7150/thno.40532
[Abstract] [Full text] [PDF]


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Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics
Peng Mi
Theranostics 2020; 10(10): 4557-4588. doi:10.7150/thno.38069
[Abstract] [Full text] [PDF]