Theranostics 2020; 10(14):6231-6244. doi:10.7150/thno.45219

Review

Emerging role of mTOR in tumor immune contexture: Impact on chemokine-related immune cells migration

Jing Jin1, Qijie Zhao2,3,4✉

1. Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
2. Laboratory of Molecular Pharmacology, Southwest Medical University, Luzhou, 646000, Sichuan, PR China
3. Department of Pathophysiology, College of Basic Medical Science, Southwest Medical University, Luzhou, 646000, Sichuan, PR China
4. South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, PR China

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Citation:
Jin J, Zhao Q. Emerging role of mTOR in tumor immune contexture: Impact on chemokine-related immune cells migration. Theranostics 2020; 10(14):6231-6244. doi:10.7150/thno.45219. Available from https://www.thno.org/v10p6231.htm

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Abstract

During the last few decades, cell-based anti-tumor immunotherapy emerged and it has provided us with a large amount of knowledge. Upon chemokines recognition, immune cells undergo rapid trafficking and activation in disease milieu, with immune cells chemotaxis being accompanied by activation of diverse intercellular signal transduction pathways. The outcome of chemokines-mediated immune cells chemotaxis interacts with the cue of mammalian target of rapamycin (mTOR) in the tumor microenvironment (TME). Indeed, the mTOR cascade in immune cells involves migration and infiltration. In this review, we summarize the available mTOR-related chemokines, as well as the characterized upstream regulators and downstream targets in immune cells chemotaxis and assign potential underlying mechanisms in each evaluated chemokine. Specifically, we focus on the involvement of mTOR in chemokine-mediated immune related cells in the balance between tumor immunity and malignancy.

Keywords: mTOR, Chemokine, Chemotaxis, Immune cells, Tumor microenvironment (TME)