Theranostics 2020; 10(15):6886-6897. doi:10.7150/thno.46794 This issue Cite

Research Paper

Gadofullerene nanoparticles for robust treatment of aplastic anemia induced by chemotherapy drugs

Wang Jia1,2, Mingming Zhen1,2✉, Lei Li1,2, Chen Zhou1,2, Zihao Sun1,2, Shuai Liu1,2, Zhongpu Zhao1,2, Jie Li1,2, Chunru Wang1,2✉, Chunli Bai1,2✉

1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
2. University of Chinese Academy of Sciences, Beijing 100049, China.

Citation:
Jia W, Zhen M, Li L, Zhou C, Sun Z, Liu S, Zhao Z, Li J, Wang C, Bai C. Gadofullerene nanoparticles for robust treatment of aplastic anemia induced by chemotherapy drugs. Theranostics 2020; 10(15):6886-6897. doi:10.7150/thno.46794. https://www.thno.org/v10p6886.htm
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Abstract

Graphic abstract

Aplastic anemia (AA) is characterized as hypoplasia of bone marrow hematopoietic cells and hematopenia of peripheral blood cells. Though the supplement of exogenous erythropoietin (EPO) has been clinically approved for AA treatment, the side-effects hinder its further application. Here a robust treatment for AA induced by chemotherapy drugs is explored using gadofullerene nanoparticles (GFNPs).

Methods: The gadofullerene were modified with hydrogen peroxide under alkaline conditions to become the water-soluble nanoparticles (GFNPs). The physicochemical properties, in vitro chemical construction, stability, hydroxyl radical scavenging ability, in vitro cytotoxicity, antioxidant activity, in vivo treatment efficacy, therapeutic mechanism and biological distribution, metabolism, toxicity of GFNPs were examined.

Results: GFNPs with great stability and high-efficiency antioxidant activity could observably increase the number of red blood cells (RBC) in the peripheral blood of AA mice and relieve the abnormal pathological state of bone marrow. The erythropoiesis mainly includes hemopoietic stem cells (HSCs) differentiation, erythrocyte development in bone marrow and erythrocyte maturation in peripheral blood. The positive control-EPO promotes erythropoiesis by regulating HSCs differentiation and erythrocyte development in bone marrow. Different from the anti-AA mechanism of EPO, GFNPs have little impact on both the differentiation of HSCs and the myeloid erythrocyte development, but notably improve the erythrocyte maturation. Besides, GFNPs can notably decrease the excessive reactive oxygen species (ROS) and inhibit apoptosis of hemocytes in blood. In addition, GFNPs are mostly excreted from the living body and cause no serious toxicity.

Conclusion: Our work provides an insight into the advanced nanoparticles to powerfully treat AA through ameliorating the erythrocyte maturation during erythropoiesis.

Keywords: gadofullerene nanoparticles, aplastic anemia, reactive oxygen species, erythropoiesis, erythrocyte maturation


Citation styles

APA
Jia, W., Zhen, M., Li, L., Zhou, C., Sun, Z., Liu, S., Zhao, Z., Li, J., Wang, C., Bai, C. (2020). Gadofullerene nanoparticles for robust treatment of aplastic anemia induced by chemotherapy drugs. Theranostics, 10(15), 6886-6897. https://doi.org/10.7150/thno.46794.

ACS
Jia, W.; Zhen, M.; Li, L.; Zhou, C.; Sun, Z.; Liu, S.; Zhao, Z.; Li, J.; Wang, C.; Bai, C. Gadofullerene nanoparticles for robust treatment of aplastic anemia induced by chemotherapy drugs. Theranostics 2020, 10 (15), 6886-6897. DOI: 10.7150/thno.46794.

NLM
Jia W, Zhen M, Li L, Zhou C, Sun Z, Liu S, Zhao Z, Li J, Wang C, Bai C. Gadofullerene nanoparticles for robust treatment of aplastic anemia induced by chemotherapy drugs. Theranostics 2020; 10(15):6886-6897. doi:10.7150/thno.46794. https://www.thno.org/v10p6886.htm

CSE
Jia W, Zhen M, Li L, Zhou C, Sun Z, Liu S, Zhao Z, Li J, Wang C, Bai C. 2020. Gadofullerene nanoparticles for robust treatment of aplastic anemia induced by chemotherapy drugs. Theranostics. 10(15):6886-6897.

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