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Theranostics 2021; 11(11):5267-5278. doi:10.7150/thno.55571 This issue Cite

Research Paper

Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function

Xiaohui Lu1*, Jingyuan Zhang1*, Huijiao Liu1, Wenqiang Ma1, Leo Yu2, Xin Tan3, Shubin Wang3, Fazheng Ren4, Xiru Li5, Xiangdong Li1,4,6 ✉

1. State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
2. Yunnan Hempmon Pharmaceuticals Co. Ltd., Beijing, 100010, China.
3. Hanma Investment Group Co., Ltd., Beijing, 100010, China.
4. Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
5. Department of Surgery, Chinese PLA General Hospital, Beijing, 100071, China.
6. Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland.
* Xiaohui Lu, Jingyuan Zhang contributed equally to this work.

✉ Corresponding author: Xiangdong Li, State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China, xiangdongli68com, 86-10-62734389 (Tel/Fax).

Citation:
Lu X, Zhang J, Liu H, Ma W, Yu L, Tan X, Wang S, Ren F, Li X, Li X. Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function. Theranostics 2021; 11(11):5267-5278. doi:10.7150/thno.55571. https://www.thno.org/v11p5267.htm
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Abstract

Graphic abstract

Rationale: Pulmonary arterial hypertension (PAH) is a chronic disease associated with enhanced proliferation of pulmonary artery smooth muscle cells (PASMCs) and dysfunctional mitochondria, and the clinical therapeutic option for PAH is very limited. Recent studies showed that cannabidiol (CBD), a non-psychoactive constituent of cannabinoids, possessed antioxidant effect towards several cardiovascular diseases, whereas the mechanistic effect of CBD in PAH is unknown.

Methods: In this study, the effects of CBD in PAH were determined by analyzing its preventive and therapeutic actions in PAH rodent models in vivo and PASMCs' proliferation test in vitro. Additionally, CBD's roles in mitochondrial function and oxidant stress were also assessed in PASMCs.

Results: We found that CBD reversed the pathological changes observed in both Sugen-hypoxia and monocrotaline-induced PAH rodent models in a cannabinoid receptors-independent manner. Our results also demonstrated that CBD significantly inhibited the PASMCs' proliferation in PAH mice with less inflammation and reactive oxygen species levels. Moreover, CBD alleviated rodent PAH by recovering mitochondrial energy metabolism, normalizing the hypoxia-induced oxidant stress, reducing the lactate overaccumulation and abnormal glycolysis.

Conclusions: Taken together, these findings confirm an important role for CBD in PAH pathobiology.

Keywords: Cannabinoids, Pulmonary arterial hypertension, Antioxidant, Mitochondria networks, Glycolysis.

Citation styles

APA
Lu, X., Zhang, J., Liu, H., Ma, W., Yu, L., Tan, X., Wang, S., Ren, F., Li, X., Li, X. (2021). Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function. Theranostics, 11(11), 5267-5278. https://doi.org/10.7150/thno.55571.

ACS
Lu, X.; Zhang, J.; Liu, H.; Ma, W.; Yu, L.; Tan, X.; Wang, S.; Ren, F.; Li, X.; Li, X. Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function. Theranostics 2021, 11 (11), 5267-5278. DOI: 10.7150/thno.55571.

NLM
Lu X, Zhang J, Liu H, Ma W, Yu L, Tan X, Wang S, Ren F, Li X, Li X. Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function. Theranostics 2021; 11(11):5267-5278. doi:10.7150/thno.55571. https://www.thno.org/v11p5267.htm

CSE
Lu X, Zhang J, Liu H, Ma W, Yu L, Tan X, Wang S, Ren F, Li X, Li X. 2021. Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function. Theranostics. 11(11):5267-5278.

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