Theranostics 2021; 11(12):5889-5910. doi:10.7150/thno.56157 This issue


High fat diet, gut microbiome and gastrointestinal cancer

Yao Tong1#, Huiru Gao1#, Qiuchen Qi1#, Xiaoyan Liu1, Juan Li1, Jie Gao1, Peilong Li1, Yunshan Wang1, Lutao Du1✉, Chuanxin Wang1,2,3✉

1. Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
2. Shandong Engineering & Technology Research Center for Tumor Marker Detection, Jinan, Shandong, China.
3. Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory, Jinan, Shandong, China.
#These authors contributed equally to this article.

This is an open access article distributed under the terms of the Creative Commons Attribution License ( See for full terms and conditions.
Tong Y, Gao H, Qi Q, Liu X, Li J, Gao J, Li P, Wang Y, Du L, Wang C. High fat diet, gut microbiome and gastrointestinal cancer. Theranostics 2021; 11(12):5889-5910. doi:10.7150/thno.56157. Available from

File import instruction


Graphic abstract

Gastrointestinal cancer is currently one of the main causes of cancer death, with a large number of cases and a wide range of lesioned sites. A high fat diet, as a public health problem, has been shown to be correlated with various digestive system diseases and tumors, and can accelerate the occurrence of cancer due to inflammation and altered metabolism. The gut microbiome has been the focus of research in recent years, and associated with cell damage or tumor immune microenvironment changes via direct or extra-intestinal effects; this may facilitate the occurrence and development of gastrointestinal tumors. Based on research showing that both a high fat diet and gut microbes can promote the occurrence of gastrointestinal tumors, and that a high fat diet imbalances intestinal microbes, we propose that a high fat diet drives gastrointestinal tumors by changing the composition of intestinal microbes.

Keywords: high fat diet, gastrointestinal cancer, gut microbiome, inflammation, metabolic reprogramming