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Theranostics 2021; 11(16):8027-8042. doi:10.7150/thno.61207 This issue Cite

Review

Radiomics in prostate cancer imaging for a personalized treatment approach - current aspects of methodology and a systematic review on validated studies

Simon K.B. Spohn1,2,11✉*, Alisa S. Bettermann1*, Fabian Bamberg3, Matthias Benndorf3, Michael Mix4, Nils H. Nicolay1,2, Tobias Fechter5, Tobias Hölscher6,7, Radu Grosu8, Arturo Chiti9,10, Anca L. Grosu1,2, Constantinos Zamboglou1,2,11,12

1. Department of Radiation Oncology, Medical Center - University of Freiburg, Faculty of Medicine. University of Freiburg, Germany
2. German Cancer Consortium (DKTK). Partner Site Freiburg, Germany
3. Department of Radiology, Medical Center - University of Freiburg, Faculty of Medicine. University of Freiburg, Germany
4. Department of Nuclear Medicine, Medical Center - University of Freiburg, Faculty of Medicine. University of Freiburg, Germany
5. Department of Radiation Oncology - Division of Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine. University of Freiburg, Germany
6. Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden.
7. OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany
8. Institute of Computer Engineering, Vienne University of Technology, Vienna, Austria
9. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele - Milan, Italy
10. IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano - Milan, Italy
11. Berta-Ottenstein-Programme, Faculty of Medicine, University of Freiburg, Germany
12. German Oncology Center, European University of Cyprus, Limassol, Cyprus
* shared authorship

✉ Corresponding author: Simon Spohn, Department of Radiation Oncology, Medical Center - University of Freiburg, Robert-Koch Straße 3, 79106 Freiburg. Telephone: +49 (0)761 270 94010; Email: simon.spohnde

Citation:
Spohn SKB, Bettermann AS, Bamberg F, Benndorf M, Mix M, Nicolay NH, Fechter T, Hölscher T, Grosu R, Chiti A, Grosu AL, Zamboglou C. Radiomics in prostate cancer imaging for a personalized treatment approach - current aspects of methodology and a systematic review on validated studies. Theranostics 2021; 11(16):8027-8042. doi:10.7150/thno.61207. https://www.thno.org/v11p8027.htm
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Abstract

Graphic abstract

Prostate cancer (PCa) is one of the most frequently diagnosed malignancies of men in the world. Due to a variety of treatment options in different risk groups, proper diagnostic and risk stratification is pivotal in treatment of PCa. The development of precise medical imaging procedures simultaneously to improvements in big data analysis has led to the establishment of radiomics - a computer-based method of extracting and analyzing image features quantitatively. This approach bears the potential to assess and improve PCa detection, tissue characterization and clinical outcome prediction. This article gives an overview on the current aspects of methodology and systematically reviews available literature on radiomics in PCa patients, showing its potential for personalized therapy approaches. The qualitative synthesis includes all imaging modalities and focuses on validated studies, putting forward future directions.

Citation styles

APA
Spohn, S.K.B., Bettermann, A.S., Bamberg, F., Benndorf, M., Mix, M., Nicolay, N.H., Fechter, T., Hölscher, T., Grosu, R., Chiti, A., Grosu, A.L., Zamboglou, C. (2021). Radiomics in prostate cancer imaging for a personalized treatment approach - current aspects of methodology and a systematic review on validated studies. Theranostics, 11(16), 8027-8042. https://doi.org/10.7150/thno.61207.

ACS
Spohn, S.K.B.; Bettermann, A.S.; Bamberg, F.; Benndorf, M.; Mix, M.; Nicolay, N.H.; Fechter, T.; Hölscher, T.; Grosu, R.; Chiti, A.; Grosu, A.L.; Zamboglou, C. Radiomics in prostate cancer imaging for a personalized treatment approach - current aspects of methodology and a systematic review on validated studies. Theranostics 2021, 11 (16), 8027-8042. DOI: 10.7150/thno.61207.

NLM
Spohn SKB, Bettermann AS, Bamberg F, Benndorf M, Mix M, Nicolay NH, Fechter T, Hölscher T, Grosu R, Chiti A, Grosu AL, Zamboglou C. Radiomics in prostate cancer imaging for a personalized treatment approach - current aspects of methodology and a systematic review on validated studies. Theranostics 2021; 11(16):8027-8042. doi:10.7150/thno.61207. https://www.thno.org/v11p8027.htm

CSE
Spohn SKB, Bettermann AS, Bamberg F, Benndorf M, Mix M, Nicolay NH, Fechter T, Hölscher T, Grosu R, Chiti A, Grosu AL, Zamboglou C. 2021. Radiomics in prostate cancer imaging for a personalized treatment approach - current aspects of methodology and a systematic review on validated studies. Theranostics. 11(16):8027-8042.

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