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Theranostics 2022; 12(4):1756-1768. doi:10.7150/thno.68756 This issue Cite

Research Paper

A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy

Jiahui Peng1,2, Fangman Chen1,2✉, Yulu Liu1,2, Fan Zhang2, Lei Cao1,2, Qiannan You1,2, Dian Yang1,2, Zhimin Chang2, Mingfeng Ge2, Li Li2, Zheng Wang6, Qian Mei2, Dan Shao3,4,5✉, Meiwan Chen7, Wen-Fei Dong1,2✉

1. School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, China.
2. CAS Key Laboratory of Bio Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, 88 Keling Road, Suzhou 215163, China.
3. Institutes of Life Sciences, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.
4. School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong 511442, China.
5. National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong 510006, China.
6. CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Suzhou 215123, China.
7. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.

✉ Corresponding authors: Fangman Chen, E-mail: chenfangmancom. Dan Shao, Prof., E-mail:stanauagatecom. Wen-fei Dong, Prof., E-mail: wenfeidongac.cn.

Citation:
Peng J, Chen F, Liu Y, Zhang F, Cao L, You Q, Yang D, Chang Z, Ge M, Li L, Wang Z, Mei Q, Shao D, Chen M, Dong WF. A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy. Theranostics 2022; 12(4):1756-1768. doi:10.7150/thno.68756. https://www.thno.org/v12p1756.htm
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Abstract

Graphic abstract

Designing a transformable nanosystem with improved tumor accumulation and penetration by tuning multiple physicochemical properties remains a challenge. Here, a near-infrared (NIR) light-driven nanosystem with size and charge dual-transformation for deep tumor penetration is developed.

Methods: The core-shell nanotransformer is realized by integrating diselenide-bridged mesoporous organosilica nanoparticles as a reactive oxygen species (ROS)-responsive core with an indocyanine green (ICG)-hybrid N-isopropyl acrylamide layer as a thermosensitive shell. After loading doxorubicin (DOX), negatively charged nanomedicine prevents DOX leakage, rendering prolonged blood circulation time and high tumor accumulation.

Results: Upon NIR light irradiation, mild photothermal effects facilitate the dissociation of the thermosensitive shell to achieve negative-to-positive charge reversal. Meanwhile, ICG-generated ROS cleave the diselenide bond of the organosilica core, resulting in rapid matrix degradation that produces DOX-containing smaller fragments. Such a light-driven dual-transformable nanomedicine simultaneously promotes deep tumor penetration and implements sufficient chemotherapy, along with evoking robust immunogenic cell death effects in vitro and in vivo. With the combination of a programmed cell death protein-1 (PD-1) checkpoint blockade, the nanotransformer remarkably blocks primary tumor growth and pulmonary metastasis of breast cancer with low systemic toxicity.

Conclusions: This study develops a promising strategy to realize high tumor accumulation and deep penetration of light-transformable nanomedicine for efficient and safe chemo-immunotherapy.

Keywords: phototherapy, light response, tumor penetration, mesoporous organosilica nanoparticles, immunotherapy

Citation styles

APA
Peng, J., Chen, F., Liu, Y., Zhang, F., Cao, L., You, Q., Yang, D., Chang, Z., Ge, M., Li, L., Wang, Z., Mei, Q., Shao, D., Chen, M., Dong, W.F. (2022). A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy. Theranostics, 12(4), 1756-1768. https://doi.org/10.7150/thno.68756.

ACS
Peng, J.; Chen, F.; Liu, Y.; Zhang, F.; Cao, L.; You, Q.; Yang, D.; Chang, Z.; Ge, M.; Li, L.; Wang, Z.; Mei, Q.; Shao, D.; Chen, M.; Dong, W.F. A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy. Theranostics 2022, 12 (4), 1756-1768. DOI: 10.7150/thno.68756.

NLM
Peng J, Chen F, Liu Y, Zhang F, Cao L, You Q, Yang D, Chang Z, Ge M, Li L, Wang Z, Mei Q, Shao D, Chen M, Dong WF. A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy. Theranostics 2022; 12(4):1756-1768. doi:10.7150/thno.68756. https://www.thno.org/v12p1756.htm

CSE
Peng J, Chen F, Liu Y, Zhang F, Cao L, You Q, Yang D, Chang Z, Ge M, Li L, Wang Z, Mei Q, Shao D, Chen M, Dong WF. 2022. A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy. Theranostics. 12(4):1756-1768.

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