Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

Chen, Sheng; Gan, Donghao; Lin, Sixiong; Zhong, Yiming; Chen, Mingjue; Zou, Xuenong; Shao, Zengwu; Xiao, Guozhi

doi:10.7150/thno.71360

Nanotheranostics 2025; 9(1): 38-51. Full text PDF

Nanotheranostics 2025; 9(1): 31-37. Full text PDF

Nanotheranostics

International Journal of Biological Sciences

International Journal of Medical Sciences

Journal of Cancer

open access Global reach, higher impact

Full Text | PDF

Theranostics 2022; 12(6):2722-2740. doi:10.7150/thno.71360 This issue Cite

Review

Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

Sheng Chen^1,2#, Donghao Gan^2#, Sixiong Lin^2,3#, Yiming Zhong^2#, Mingjue Chen², Xuenong Zou³, Zengwu Shao^1✉, Guozhi Xiao^2✉

1. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
2. Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Shenzhen, 518055, China.
3. Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology, Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
^#These authors contributed equally to this study

Citation:

Chen S, Gan D, Lin S, Zhong Y, Chen M, Zou X, Shao Z, Xiao G. Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. Theranostics 2022; 12(6):2722-2740. doi:10.7150/thno.71360. https://www.thno.org/v12p2722.htm

Other styles

Abstract

Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i.e., aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease, cardiovascular diseases, cancers, obesity and other metabolic abnormalities. Metformin, the most widely used antidiabetic drug, has been reported to delay aging and display protective effect on attenuating progression of various aging-related diseases by impacting key hallmark events of aging, including dysregulated nutrient sensing, loss of proteostasis, mitochondrial dysfunction, altered intercellular communication, telomere attrition, genomic instability, epigenetic alterations, stem cell exhaustion and cellular senescence. In this review, we provide updated information and knowledge on applications of metformin in prevention and treatment of aging and aging-related diseases. We focus our discussions on the roles and underlying mechanisms of metformin in modulating aging and treating aging-related diseases.

Keywords: Metformin, aging, aging-related diseases, clinical application, molecular mechanism.

Citation styles

APA

Chen, S., Gan, D., Lin, S., Zhong, Y., Chen, M., Zou, X., Shao, Z., Xiao, G. (2022). Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. Theranostics, 12(6), 2722-2740. https://doi.org/10.7150/thno.71360.

ACS

Chen, S.; Gan, D.; Lin, S.; Zhong, Y.; Chen, M.; Zou, X.; Shao, Z.; Xiao, G. Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. Theranostics 2022, 12 (6), 2722-2740. DOI: 10.7150/thno.71360.

NLM

CSE

Chen S, Gan D, Lin S, Zhong Y, Chen M, Zou X, Shao Z, Xiao G. 2022. Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. Theranostics. 12(6):2722-2740.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.