Theranostics 2022; 12(18):7717-7728. doi:10.7150/thno.78851 This issue Cite

Research Paper

Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy

Xiang He1*, Jie Liu2,3*, Xiaojun Xiao2,3*, Shuang Zhang2,3*, Xinxin Wang2,3, Jiangqi Liu4, Zhiqiang Liu4, Junyi Wang1, Xiaoyu Liu2,3✉, Guoping Li1✉, Pingchang Yang2,3✉

1. Laboratory of Allergy and Precision Medicine, Chengdu Institute of Respiratory Health, the Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
2. Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Shenzhen, China.
3. Institute of Allergy & Immunology, Shenzhen University School of Medicine, State Key Laboratory of Respiratory Disease Allergy Division at Shenzhen University, Shenzhen, China.
4. Longgang ENT Hospital & Shenzhen ENT Institute, Shenzhen, China.
* Equally contributed to this work

Citation:
He X, Liu J, Xiao X, Zhang S, Wang X, Liu J, Liu Z, Wang J, Liu X, Li G, Yang P. Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy. Theranostics 2022; 12(18):7717-7728. doi:10.7150/thno.78851. https://www.thno.org/v12p7717.htm
Other styles

File import instruction

Abstract

Graphic abstract

Background: The therapeutic efficacy of allergen specific immunotherapy (SIT) is recognized, but needs improved. Psychological stress influences the immune system's function. The objective of this study is to elucidate the effects of psychological stress on compromising the effectiveness of SIT.

Methods: A murine model with the airway allergic disorder (AAD) was established. Mice were treated with SIT with or without restraint stress (Rs).

Results: Rs was found to significantly hamper the efficacy of SIT in mice with AAD. Induction of IL-10+ dendritic cells and type 1 regulatory T cells were reduced by Rs in the airway tissues. Rs-induced cortisol release subverted immune tolerance generation. Expression of MARCH1 was elevated in dendritic cells of the allergic lesion sites. The Rs-induced MARCH1 mediated the immune impairment in AAD mice. Genetic ablation of MARCH1 in dendritic cells efficiently blocked the Rs-compromised the therapeutic efficacy of SIT.

Conclusion: Rs can increase the expression of MARCH1 in DCs of the allergic lesion sites. MARCH1 interferes with the immune regulatory properties in DCs, and impairs the immune regulatory capacity. Blocking MARCH1 can counteract the Rs-affected SIT efficacy.

Keywords: allergy, immunotherapy, psychological stress, immune regulation, dendritic cells.


Citation styles

APA
He, X., Liu, J., Xiao, X., Zhang, S., Wang, X., Liu, J., Liu, Z., Wang, J., Liu, X., Li, G., Yang, P. (2022). Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy. Theranostics, 12(18), 7717-7728. https://doi.org/10.7150/thno.78851.

ACS
He, X.; Liu, J.; Xiao, X.; Zhang, S.; Wang, X.; Liu, J.; Liu, Z.; Wang, J.; Liu, X.; Li, G.; Yang, P. Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy. Theranostics 2022, 12 (18), 7717-7728. DOI: 10.7150/thno.78851.

NLM
He X, Liu J, Xiao X, Zhang S, Wang X, Liu J, Liu Z, Wang J, Liu X, Li G, Yang P. Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy. Theranostics 2022; 12(18):7717-7728. doi:10.7150/thno.78851. https://www.thno.org/v12p7717.htm

CSE
He X, Liu J, Xiao X, Zhang S, Wang X, Liu J, Liu Z, Wang J, Liu X, Li G, Yang P. 2022. Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy. Theranostics. 12(18):7717-7728.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image