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Theranostics 2023; 13(5):1716-1744. doi:10.7150/thno.80529 This issue Cite

Review

Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications

Jiarao Sun1, Xiaoli Cao2, Wenjuan Lu1, Yongchun Wei1, Lingxiu Kong1, Wei Chen1, Xintian Shao3,✉, Yanfeng Wang1,✉

1. Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, Shandong Province, China
2. Jinan Municipal Center for Disease Control and Prevention, Jinan 250021, Shandong, China
3. School of Life Sciences, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China

✉ Corresponding authors: Y. F. Wang and X.T. Shao, Email: wangyanfengedu.cn (Y. F. Wang); shaoxintianedu.cn (X.T. Shao).

Citation:
Sun J, Cao X, Lu W, Wei Y, Kong L, Chen W, Shao X, Wang Y. Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications. Theranostics 2023; 13(5):1716-1744. doi:10.7150/thno.80529. https://www.thno.org/v13p1716.htm
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Abstract

Graphic abstract

Peroxynitrite (ONOO-), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition to various pathological processes, including those related to neurodegenerative diseases and cancer. Detection of ONOO- at the cellular level is of great significance to understand its pathogenesis. To this end, a variety of fluorescent probes based on small molecules and nanoparticles (NPs) have been engineered and applied as excellent tools for imaging of ONOO- in cells as well as in their diverse biological applications. In this review, we highlight representative cases of fluorescent probes based on recognition mechanism and emphasize their response type (ratiometric, two-photon, long-wavelength/near-infrared, and targeting) in ONOO- detection in the last five years. We further discuss their design strategy, sensing mechanism, and application in bio-imaging and describe NP-based probes according to diverse nanoplatforms.

Keywords: peroxynitrite, fluorescent probes, nanoparticles, response mechanisms, bio-imaging

Citation styles

APA
Sun, J., Cao, X., Lu, W., Wei, Y., Kong, L., Chen, W., Shao, X., Wang, Y. (2023). Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications. Theranostics, 13(5), 1716-1744. https://doi.org/10.7150/thno.80529.

ACS
Sun, J.; Cao, X.; Lu, W.; Wei, Y.; Kong, L.; Chen, W.; Shao, X.; Wang, Y. Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications. Theranostics 2023, 13 (5), 1716-1744. DOI: 10.7150/thno.80529.

NLM
Sun J, Cao X, Lu W, Wei Y, Kong L, Chen W, Shao X, Wang Y. Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications. Theranostics 2023; 13(5):1716-1744. doi:10.7150/thno.80529. https://www.thno.org/v13p1716.htm

CSE
Sun J, Cao X, Lu W, Wei Y, Kong L, Chen W, Shao X, Wang Y. 2023. Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications. Theranostics. 13(5):1716-1744.

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