Theranostics 2023; 13(6):1823-1825. doi:10.7150/thno.83486 This issue Cite

Editorial

A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy

Uttam K. Sinha1✉, De-Chen Lin2 ✉

1. Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
2. Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.

Citation:
Sinha UK, Lin DC. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics 2023; 13(6):1823-1825. doi:10.7150/thno.83486. https://www.thno.org/v13p1823.htm
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Abstract

Gene expression network in cancer cells is orchestrated by a small number of master regulator transcription factors (MRTFs), which play a prominent role in regulating cancer intrinsic hallmarks, such as sustaining proliferative signaling, evading growth suppressors, resisting cell death, etc. A new study reports a new role of one MRTF, KLF5, in regulating tumor microenvironment in an extrinsic manner. These findings not only reveal novel mechanistic underpinnings of tumor evasion from immune destruction but also broaden our understanding of the transcriptional deregulation in cancer biology.


Citation styles

APA
Sinha, U.K., Lin, D.C. (2023). A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics, 13(6), 1823-1825. https://doi.org/10.7150/thno.83486.

ACS
Sinha, U.K.; Lin, D.C. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics 2023, 13 (6), 1823-1825. DOI: 10.7150/thno.83486.

NLM
Sinha UK, Lin DC. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics 2023; 13(6):1823-1825. doi:10.7150/thno.83486. https://www.thno.org/v13p1823.htm

CSE
Sinha UK, Lin DC. 2023. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics. 13(6):1823-1825.

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