Theranostics
2023; 13(6):1823-1825.
doi:10.7150/thno.83486 This issueCite
Editorial
A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy
Uttam K. Sinha1✉, De-Chen Lin2 ✉
1. Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, USA. 2. Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
✉ Corresponding authors: Uttam K Sinha, MD, MS, FACS: Department of otolaryngology, Keck School of Medicine, University of Southern California, 1537 Norfolk Street, Suite 5800, Los Angeles, CA 90033. email: sinhausc.edu. De-Chen Lin, Ph.D: Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street - CSA 207D, Los Angeles, CA 90033. Phone: (323) 442-1220, Fax: (323) 442-2981, email: dechenlieduMore
Citation:
Sinha UK, Lin DC. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics 2023; 13(6):1823-1825. doi:10.7150/thno.83486. https://www.thno.org/v13p1823.htm
Gene expression network in cancer cells is orchestrated by a small number of master regulator transcription factors (MRTFs), which play a prominent role in regulating cancer intrinsic hallmarks, such as sustaining proliferative signaling, evading growth suppressors, resisting cell death, etc. A new study reports a new role of one MRTF, KLF5, in regulating tumor microenvironment in an extrinsic manner. These findings not only reveal novel mechanistic underpinnings of tumor evasion from immune destruction but also broaden our understanding of the transcriptional deregulation in cancer biology.
Citation styles
APA
Sinha, U.K., Lin, D.C. (2023). A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics, 13(6), 1823-1825. https://doi.org/10.7150/thno.83486.
ACS
Sinha, U.K.; Lin, D.C. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics 2023, 13 (6), 1823-1825. DOI: 10.7150/thno.83486.
NLM
Sinha UK, Lin DC. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics 2023; 13(6):1823-1825. doi:10.7150/thno.83486. https://www.thno.org/v13p1823.htm
CSE
Sinha UK, Lin DC. 2023. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics. 13(6):1823-1825.
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.