Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Theranostics 2023; 13(15):5322-5347. doi:10.7150/thno.87356 This issue Cite

Review

Peptide-drug co-assembling: A potent armament against cancer

Can Wu1, Manman Wang1, Jinpan Sun1, Yongyan Jia1, Xiali Zhu1, Gaizhi Liu1, Yanhui Zhu1, Yanbin Guan1✉, Zhenqiang Zhang2✉, Xin Pang1✉

1. School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
2. Academy of Chinese Medicine Science, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.

✉ Corresponding authors: Xin Pang (pangxin116com); Zhenqiang Zhang (zhang_zhenqiangcom); Yanbin Guan (guanyanbin96com).

Citation:
Wu C, Wang M, Sun J, Jia Y, Zhu X, Liu G, Zhu Y, Guan Y, Zhang Z, Pang X. Peptide-drug co-assembling: A potent armament against cancer. Theranostics 2023; 13(15):5322-5347. doi:10.7150/thno.87356. https://www.thno.org/v13p5322.htm
Other styles

File import instruction

Abstract

Graphic abstract

Cancer is still one of the major problems threatening human health and the therapeutical efficacies of available treatment choices are often rather low. Due to their favorable biocompatibility, simplicity of modification, and improved therapeutic efficacy, peptide-based self-assembled delivery systems have undergone significant evolution. Physical encapsulation and covalent conjugation are two common approaches to load drugs for peptide assembly-based delivery, which are always associated with drug leaks in the blood circulation system or changed pharmacological activities, respectively. To overcome these difficulties, a more elegant peptide-based assembly strategy is desired. Notably, peptide-mediated co-assembly with drug molecules provides a new method for constructing nanomaterials with improved versatility and structural stability. The co-assembly strategy can be used to design various nanostructures for cancer therapy, such as nanotubes, nanofibrils, hydrogels, and nanovesicles. Recently, these co-assembled nanostructures have gained tremendous attention for their unique superiorities in tumor therapy. This article describes the classification of assembled peptides, driving forces for co-assembly, and specifically, the design methodologies for various drug molecules in co-assembly. It also highlights recent research on peptide-mediated co-assembled delivery systems for cancer therapy. Finally, it summarizes the pros and cons of co-assembly in cancer therapy and offers some suggestions for conquering the challenges in this field.

Keywords: peptide, co-assembly, nanostructures, drug delivery, cancer therapy

Citation styles

APA
Wu, C., Wang, M., Sun, J., Jia, Y., Zhu, X., Liu, G., Zhu, Y., Guan, Y., Zhang, Z., Pang, X. (2023). Peptide-drug co-assembling: A potent armament against cancer. Theranostics, 13(15), 5322-5347. https://doi.org/10.7150/thno.87356.

ACS
Wu, C.; Wang, M.; Sun, J.; Jia, Y.; Zhu, X.; Liu, G.; Zhu, Y.; Guan, Y.; Zhang, Z.; Pang, X. Peptide-drug co-assembling: A potent armament against cancer. Theranostics 2023, 13 (15), 5322-5347. DOI: 10.7150/thno.87356.

NLM
Wu C, Wang M, Sun J, Jia Y, Zhu X, Liu G, Zhu Y, Guan Y, Zhang Z, Pang X. Peptide-drug co-assembling: A potent armament against cancer. Theranostics 2023; 13(15):5322-5347. doi:10.7150/thno.87356. https://www.thno.org/v13p5322.htm

CSE
Wu C, Wang M, Sun J, Jia Y, Zhu X, Liu G, Zhu Y, Guan Y, Zhang Z, Pang X. 2023. Peptide-drug co-assembling: A potent armament against cancer. Theranostics. 13(15):5322-5347.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use