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Theranostics 2024; 14(8):3246-3266. doi:10.7150/thno.93755 This issue Cite

Review

Bioinspired cellular membrane-derived vesicles for mRNA delivery

Xiao Xu^1,†, Limei Xu^1,†, Jingzhi Wang¹, Caining Wen¹, Jiang Xia^2,✉, Yuanmin Zhang^1,3,✉, Yujie Liang^1,3,✉

1. Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.
2. Department of Chemistry, The Chinese University of Hong Kong, Hong Kong, China.
3. College of Rehabilitation Medicine, Jining Medical University, Jining, China.
† These authors contributed equally.

✉ Corresponding authors: Jiang Xia (jiangxiaedu.hk), Yuanmin Zhang (yuanminzhangjnmc.edu.cn), Yujie Liang (liangyjiecom).

Abstract

The rapid advancement of mRNA as vaccines and therapeutic agents in the biomedical field has sparked hope in the fight against untreatable diseases. Successful clinical application of mRNA therapeutics largely depends on the carriers. Recently, a new and exciting focus has emerged on natural cell-derived vesicles. These nanovesicles offer many functions, including enhanced drug delivery capabilities and immune evasion, thereby presenting a unique and promising platform for the effective and safe delivery of mRNA therapeutics. In this study, we summarize the characteristics and properties of biomimetic delivery systems for mRNA therapeutics. In particular, we discuss the unique features of cellular membrane-derived vesicles (CDVs) and the combination of synthetic nanovesicles with CDVs.

Keywords: cellular membrane-derived vesicles, exosomes, extracellular vesicle, mRNA delivery, mRNA vaccine

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