Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies

Liu, Yun; Guo, Jianfeng; Huang, Leaf

doi:10.7150/thno.42998

Nanotheranostics

International Journal of Biological Sciences

International Journal of Medical Sciences

Journal of Cancer

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Theranostics 2020; 10(7):3099-3117. doi:10.7150/thno.42998 This issue Cite

Review

Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies

Yun Liu¹, Jianfeng Guo^1,2✉, Leaf Huang^1✉

1. Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States
2. School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China

Citation:

Liu Y, Guo J, Huang L. Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies. Theranostics 2020; 10(7):3099-3117. doi:10.7150/thno.42998. https://www.thno.org/v10p3099.htm

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Abstract

Recent advances in the field of immunotherapy have profoundly opened up the potential for improved cancer therapy and reduced side effects. However, the tumor microenvironment (TME) is highly immunosuppressive, therefore, clinical outcomes of currently available cancer immunotherapy are still poor. Recently, nanomaterial-based strategies have been developed to modulate the TME for robust immunotherapeutic responses. In this review, the immunoregulatory cell types (cells relating to the regulation of immune responses) inside the TME in terms of stimulatory and suppressive roles are described, and the technologies used to identify and quantify these cells are provided. In addition, recent examples of nanomaterial-based cancer immunotherapy are discussed, with particular emphasis on those designed to overcome barriers caused by the complexity and diversity of TME.

Keywords: tumor immunology, characterization and quantification of immunoregulatory cells, nanoparticles, drug delivery, combination therapy

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APA

Liu, Y., Guo, J., Huang, L. (2020). Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies. Theranostics, 10(7), 3099-3117. https://doi.org/10.7150/thno.42998.

ACS

Liu, Y.; Guo, J.; Huang, L. Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies. Theranostics 2020, 10 (7), 3099-3117. DOI: 10.7150/thno.42998.

NLM

CSE

Liu Y, Guo J, Huang L. 2020. Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies. Theranostics. 10(7):3099-3117.

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