Theranostics 2021; 11(6):2755-2769. doi:10.7150/thno.56174
Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment
1. Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
3. Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, China.
4. Shanghai Pancreatic Cancer Institute, Shanghai, 200032, China.
#These authors contributed equally to this work.
Rong Z, Xu J, Shi S, Tan Z, Meng Q, Hua J, Liu J, Zhang B, Wang W, Yu X, Liang C. Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment. Theranostics 2021; 11(6):2755-2769. doi:10.7150/thno.56174. Available from https://www.thno.org/v11p2755.htm
Pancreatic cancer (PC), an important cause of cancer-related deaths worldwide, is one of the most malignant cancers characterized by a dismal prognosis. Circular RNAs (circRNAs), a class of endogenous ncRNAs with unique covalently closed loops, have attracted great attention in regard to various diseases, especially cancers. Compelling studies have suggested that circRNAs are aberrantly expressed in different cancer tissues and cell types, including PC. More specifically, circRNAs can modify the proliferation, progression, tumorigenesis and chemosensitivity of PC, and some circRNAs could serve as biomarkers for diagnosis and prognosis. Herein, we summarize what is currently known to be related to the biogenesis, functions and potential roles of human circRNAs in PC and their application prospects for PC clinical treatments.
Keywords: Circular RNA, pancreatic cancer, sponge function, biomarker, treatment