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Volume 11 (6); 2021

Research Papers

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In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy
Christian Prinz, Ludger Starke, Jason M. Millward, Ariane Fillmer, Paula Ramos Delgado, Helmar Waiczies, Andreas Pohlmann, Michael Rothe, Marc Nazaré, Friedemann Paul, Thoralf Niendorf, Sonia Waiczies
Theranostics 2021; 11(6): 2490-2504. doi:10.7150/thno.47130
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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DRD1 downregulation contributes to mechanical stretch-induced lung endothelial barrier dysfunction
Yan Wang, Yu-Jian Liu, Dun-Feng Xu, Hui Zhang, Chu-Fan Xu, Yan-Fei Mao, Zhou Lv, Xiao-Yan Zhu, Lai Jiang
Theranostics 2021; 11(6): 2505-2521. doi:10.7150/thno.46192
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Neutrophils infiltrate into the spiral ligament but not the stria vascularis in the cochlea during lipopolysaccharide-induced inflammation
Seong Hoon Bae, Jee Eun Yoo, Young Ho Choe, Sang Hyun Kwak, Jae Young Choi, Jinsei Jung, Young-Min Hyun
Theranostics 2021; 11(6): 2522-2533. doi:10.7150/thno.49121
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Structurally symmetric near-infrared fluorophore IRDye78-protein complex enables multimodal cancer imaging
Jiang Yang, Chunhua Zhao, Jacky Lim, Lina Zhao, Ryan Le Tourneau, Qize Zhang, Damien Dobson, Suhasini Joshi, Jiadong Pang, Xiaodong Zhang, Suchetan Pal, Chrysafis Andreou, Hanwen Zhang, Moritz F. Kircher, Hans Schmitthenner
Theranostics 2021; 11(6): 2534-2549. doi:10.7150/thno.54928
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A bifunctional molecule-based strategy for the development of theranostic antibody-drug conjugate
Dian Xiao, Lei Zhao, Fei Xie, Shiyong Fan, Lianqi Liu, Wei Li, Ruiyuan Cao, Song Li, Wu Zhong, Xinbo Zhou
Theranostics 2021; 11(6): 2550-2563. doi:10.7150/thno.51232
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer
Wenjuan Gao, Huiping Wen, Luyu Liang, Xiaoli Dong, Renle Du, Wei Zhou, Xuehui Zhang, Chunze Zhang, Rong Xiang, Na Li
Theranostics 2021; 11(6): 2564-2580. doi:10.7150/thno.45280
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis
Wei-Yu Chen, Yi-Hsiu Wu, Tzu-Hsien Tsai, Ru-Fang Li, Alan Chuan-Ying Lai, Lung-Chih Li, Jenq-Lin Yang, Ya-Jen Chang
Theranostics 2021; 11(6): 2594-2611. doi:10.7150/thno.51648
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3
Weibo Feng, Wenjie Huang, Jie Chen, Chenyang Qiao, Danfei Liu, Xiaoyu Ji, Meng Xie, Tongyue Zhang, Yijun Wang, Mengyu Sun, Dean Tian, Daiming Fan, Yongzhan Nie, Kaichun Wu, Limin Xia
Theranostics 2021; 11(6): 2612-2633. doi:10.7150/thno.52199
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis
Ke Feng, Chuanrui Ma, Yuxin Liu, Xiaoxiao Yang, Zhimou Yang, Yaoxia Chen, Tengyan Xu, Chengbiao Yang, Shuang Zhang, Qi Li, Zhuo Wei, Dan Zhao, Peng Zeng, Jihong Han, Jie Gao, Yuanli Chen, Yajun Duan
Theranostics 2021; 11(6): 2634-2654. doi:10.7150/thno.53139
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness
Chao Jing, Yuansheng Duan, Mengqian Zhou, Kai Yue, Shanshan Zhuo, Xingchen Li, Dandan Liu, Beibei Ye, Qingchuan Lai, Linqi Li, Xiaofeng Yao, Hui Wei, Wenchao Zhang, Yansheng Wu, Xudong Wang
Theranostics 2021; 11(6): 2655-2669. doi:10.7150/thno.48375
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system against immune-associated nephropathy without glucocorticoid side effect
Kui Fan, Li Zeng, Jing Guo, Shuqin Xie, Yuan Yu, Jianwei Chen, Jin Cao, Qinyanqiu Xiang, Siliang Zhang, Yuanli Luo, Qingyue Deng, Qin Zhou, Yan Zhao, Lan Hao, Zhigang Wang, Ling Zhong
Theranostics 2021; 11(6): 2670-2690. doi:10.7150/thno.53083
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia
Chengwan Zhang, Li Shen, Yifu Zhu, Ran Xu, Zhikui Deng, Xiaoning Liu, Yihan Ding, Chunling Wang, Yuye Shi, Liye Bei, Dongping Wei, Rick F. Thorne, Xu Dong Zhang, Liang Yu, Song Chen
Theranostics 2021; 11(6): 2691-2705. doi:10.7150/thno.50571
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling and preserving PTEN expression
Chao Yu, Chongxiang Xiong, Jinhua Tang, Xiying Hou, Na Liu, George Bayliss, Shougang Zhuang
Theranostics 2021; 11(6): 2706-2721. doi:10.7150/thno.48679
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Significance of serglycin and its binding partners in autocrine promotion of metastasis in esophageal cancer
Yun Zhu, Alfred K.Y. Lam, Daisy K.Y. Shum, Di Cui, Jun Zhang, Dong Dong Yan, Bin Li, Wen Wen Xu, Nikki P.Y. Lee, Kin Tak Chan, Simon Law, Sai Wah Tsao, Annie L.M. Cheung
Theranostics 2021; 11(6): 2722-2741. doi:10.7150/thno.49547
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice
Vasundhara Kain, Kevin A. Ingle, Namakkal S. Rajasekaran, Ganesh V. Halade
Theranostics 2021; 11(6): 2742-2754. doi:10.7150/thno.51183
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Neutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles
Young-Jin Youn, Sanjeeb Shrestha, Yu-Bin Lee, Jun-Kyu Kim, Jee Hyun Lee, Keun Hur, Nanda Maya Mali, Sung-Wook Nam, Sun-Hwa Kim, Sunwoong Lee, Dong-Keun Song, Hee Kyung Jin, Jae-sung Bae, Chang-Won Hong
Theranostics 2021; 11(6): 2770-2787. doi:10.7150/thno.51756
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish
Shuxian Lu, Zhaojie Lyu, Zhihao Wang, Yao Kou, Cong Liu, Shengyue Li, Mengyan Hu, Hongjie Zhu, Wenxing Wang, Ce Zhang, Yung-Shu Kuan, Yi-Wen Liu, Jianming Chen, Jing Tian
Theranostics 2021; 11(6): 2788-2805. doi:10.7150/thno.53330
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma
Shaofang Zhang, Ying Liu, Si Sun, Junying Wang, Qifeng Li, Ruijuan Yan, Yalong Gao, Haile Liu, Shuangjie Liu, Wenting Hao, Haitao Dai, Changlong Liu, Yuanming Sun, Wei Long, Xiaoyu Mu, Xiao-Dong Zhang
Theranostics 2021; 11(6): 2806-2821. doi:10.7150/thno.51912
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia
Zi-Run Jin, Dong Fang, Bo-Heng Liu, Jie Cai, Wen-Hao Tang, Hui Jiang, Guo-Gang Xing
Theranostics 2021; 11(6): 2822-2844. doi:10.7150/thno.51869
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression
Jingyi Sheng, Li Wang, Patrick Ming-Kuen Tang, Hong-Lian Wang, Jian-Chun Li, Bi-Hua Xu, Vivian Weiwen Xue, Rui-Zhi Tan, Nana Jin, Ting-Fung Chan, Xiao-Ru Huang, Ronald CW Ma, Hui-Yao Lan
Theranostics 2021; 11(6): 2845-2859. doi:10.7150/thno.51857
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2
Dongliang Wang, Chaoshuai Zhao, Fei Xu, Aimi Zhang, Mingming Jin, Kunchi Zhang, Liu Liu, Qian Hua, Jian Zhao, Jianjun Liu, Hao Yang, Gang Huang
Theranostics 2021; 11(6): 2860-2875. doi:10.7150/thno.51797
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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An advanced optical clearing protocol allows label-free detection of tissue necrosis via multiphoton microscopy in injured whole muscle
Dominik Schneidereit, Anita Bröllochs, Paul Ritter, Lucas Kreiß, Zeinab Mokhtari, Andreas Beilhack, Gerhard Krönke, Jochen A Ackermann, Maria Faas, Anika Grüneboom, Sebastian Schürmann, Oliver Friedrich
Theranostics 2021; 11(6): 2876-2891. doi:10.7150/thno.51558
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes
Shulan Han, Wenjie Wang, Shengfang Wang, Tingyuan Yang, Guifeng Zhang, Di Wang, Ruijun Ju, Yu Lu, Huimei Wang, Lianyan Wang
Theranostics 2021; 11(6): 2892-2916. doi:10.7150/thno.50928
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nanofibrous nerve guidance conduits decorated with decellularized matrix hydrogel facilitate peripheral nerve injury repair
Chushan Zheng, Zehong Yang, Shihao Chen, Fang Zhang, Zilong Rao, Cailing Zhao, Daping Quan, Ying Bai, Jun Shen
Theranostics 2021; 11(6): 2917-2931. doi:10.7150/thno.50825
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70
Seung Yeob Hyun, Huong Thuy Le, Hye-Young Min, Honglan Pei, Yijae Lim, Injae Song, Yen T. K. Nguyen, Suckchang Hong, Byung Woo Han, Ho-Young Lee
Theranostics 2021; 11(6): 2932-2952. doi:10.7150/thno.49876
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model
Zhelong Li, Ping Zhao, Yajun Zhang, Jia Wang, Chen Wang, Yunnan Liu, Guodong Yang, Lijun Yuan
Theranostics 2021; 11(6): 2953-2965. doi:10.7150/thno.49874
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation
Chunqi Liu, Liang Wang, Xiaocong Liu, Yuping Tan, Lei Tao, Yuzhou Xiao, Pengchi Deng, Huijuan Wang, Qianyi Deng, Yiyun Lin, Hui Jie, Huaqin Zhang, Jing Zhang, Yong Peng, Hu Zhang, Zongguang Zhou, Qingxiang Sun, Xiaobo Cen, Yinglan Zhao
Theranostics 2021; 11(6): 2966-2986. doi:10.7150/thno.48699
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Genome-wide study of salivary miRNAs identifies miR-423-5p as promising diagnostic and prognostic biomarker in oral squamous cell carcinoma
Chiara Romani, Elisa Salviato, Alberto Paderno, Laura Zanotti, Antonella Ravaggi, Alberto Deganello, Giulia Berretti, Tommaso Gualtieri, Sergio Marchini, Maurizio D'Incalci, Davide Mattavelli, Cesare Piazza, Paolo Bossi, Chiara Romualdi, Piero Nicolai, Eliana Bignotti
Theranostics 2021; 11(6): 2987-2999. doi:10.7150/thno.45157
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1
Zhenbo Han, Xiuxiu Wang, Zihang Xu, Yang Cao, Rui Gong, Yang Yu, Ying Yu, Xiaofei Guo, Shenzhen Liu, Meixi Yu, Wenya Ma, Yiming Zhao, Juan Xu, Xingda Li, Shuainan Li, Yan Xu, Ruijie Song, Binbin Xu, Fan Yang, Djibril Bamba, Natalia Sukhareva, Hong Lei, Manqi Gao, Wenwen Zhang, Naufal Zagidullin, Ying Zhang, Baofeng Yang, Zhenwei Pan, Benzhi Cai
Theranostics 2021; 11(6): 3000-3016. doi:10.7150/thno.47354
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Machine learning identifies stroke features between species
Salvador Castaneda-Vega, Prateek Katiyar, Francesca Russo, Kristin Patzwaldt, Luisa Schnabel, Sarah Mathes, Johann-Martin Hempel, Ursula Kohlhofer, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Ulf Ziemann, Christian la Fougere, Ulrike Ernemann, Bernd J. Pichler, Jonathan A. Disselhorst, Sven Poli
Theranostics 2021; 11(6): 3017-3034. doi:10.7150/thno.51887
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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N6-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction
Jinming Li, Lei Liang, Yongzhi Yang, Xinxiang Li, Yanlei Ma
Theranostics 2021; 11(6): 2581-2593. doi:10.7150/thno.52366
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment
Zeyin Rong, Jin Xu, Si Shi, Zhen Tan, Qingcai Meng, Jie Hua, Jiang Liu, Bo Zhang, Wei Wang, Xianjun Yu, Chen Liang
Theranostics 2021; 11(6): 2755-2769. doi:10.7150/thno.56174
[Abstract] [Full text] [PDF] [PubMed] [PMC]