Theranostics 2021; 11(7):3348-3358. doi:10.7150/thno.45889
Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis
1. The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, China.
2. School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China.
3. Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, China.
*These authors contributed equally to this work.
Li J, Mo C, Guo Y, Zhang B, Feng X, Si Q, Wu X, Zhao Z, Gong L, He D, Shao J. Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis. Theranostics 2021; 11(7):3348-3358. doi:10.7150/thno.45889. Available from https://www.thno.org/v11p3348.htm
Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
Keywords: peptidyl-prolyl cis-trans isomerases, Pin1, pathogenesis of diseases, viral infection, neurodegenerative diseases