1. The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, China. 2. School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China. 3. Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, China. *These authors contributed equally to this work.
✉ Corresponding authors: Jingyi Li, Jichun Shao and Dan He, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, China. E-mail: lijingyiedu.cn; shaoji93com; hd_baby81com.
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Li J, Mo C, Guo Y, Zhang B, Feng X, Si Q, Wu X, Zhao Z, Gong L, He D, Shao J. Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis. Theranostics 2021; 11(7):3348-3358. doi:10.7150/thno.45889. https://www.thno.org/v11p3348.htm
Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
Li J, Mo C, Guo Y, Zhang B, Feng X, Si Q, Wu X, Zhao Z, Gong L, He D, Shao J. Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis. Theranostics 2021; 11(7):3348-3358. doi:10.7150/thno.45889. https://www.thno.org/v11p3348.htm
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Li J, Mo C, Guo Y, Zhang B, Feng X, Si Q, Wu X, Zhao Z, Gong L, He D, Shao J. 2021. Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis. Theranostics. 11(7):3348-3358.
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