Theranostics 2021; 11(7):3348-3358. doi:10.7150/thno.45889


Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis

Jingyi Li1,2✉*, Chunfen Mo3*, Yifan Guo2, Bowen Zhang1, Xiao Feng2, Qiuyue Si2, Xiaobo Wu2, Zhe Zhao2, Lixin Gong1, Dan He1✉, Jichun Shao1✉

1. The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, China.
2. School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China.
3. Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, China.
*These authors contributed equally to this work.

This is an open access article distributed under the terms of the Creative Commons Attribution License ( See for full terms and conditions.
Li J, Mo C, Guo Y, Zhang B, Feng X, Si Q, Wu X, Zhao Z, Gong L, He D, Shao J. Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis. Theranostics 2021; 11(7):3348-3358. doi:10.7150/thno.45889. Available from

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Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.

Keywords: peptidyl-prolyl cis-trans isomerases, Pin1, pathogenesis of diseases, viral infection, neurodegenerative diseases