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Theranostics 2023; 13(6):1974-2014. doi:10.7150/thno.80887 This issue Cite

Review

Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions

Haiyan Gao1#, Zhiping Cao2#, Huanhuan Liu1, Lijuan Chen1, Yan Bai1, Qingxia Wu1, Xuan Yu1, Wei Wei1, Meiyun Wang1,3✉

1. Department of Medical Imaging, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, 450003, P. R. China.
2. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, 999077, China.
3. Laboratory of Brain Science and Brain-Like Intelligence Technology, Institute for Integrated Medical Science and Engineering, Henan Academy of Sciences, Zhengzhou, 450003, P. R. China.
# These authors contributed equally to this work.

✉ Corresponding author: Meiyun Wang; Mailing address: Department of Medical Imaging, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, 450003, P. R. China. Email: mywangedu.cn.

Citation:
Gao H, Cao Z, Liu H, Chen L, Bai Y, Wu Q, Yu X, Wei W, Wang M. Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions. Theranostics 2023; 13(6):1974-2014. doi:10.7150/thno.80887. https://www.thno.org/v13p1974.htm
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Abstract

Graphic abstract

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to activate the Fenton reaction or Fenton-like reaction to generate strong oxidative hydroxyl radicals for tumor-specific treatment. It is highly selective and safe, without depth limitation of tissue penetration, and shows its potential as a new green therapeutic method with great clinical application. However, the catalytic efficiency of reagents involved in the Fenton reaction is severely affected by the inherent microenvironmental limitations of tumors and the strict Fenton reaction-dependent conditions. With the increasing application of nanotechnology in the medical field, combined therapies based on different types of functional nanomaterials have opened up new avenues for the development of next-generation CDT-enhanced system. This review will comprehensively exemplify representative results of combined therapies of CDT with other antitumor therapies such as chemotherapy, phototherapy, sonodynamic therapy, radiation therapy, magnetic hyperthermia therapy, immunotherapy, starvation therapy, gas therapy, gene therapy, oncosis therapy, or a combination thereof for improving antitumor efficiency from hundreds of the latest literature, introduce strategies such as the ingenious design of nanomedicines and tumor microenvironment regulations to enhance the combination therapy, and further summarize the challenges and future perspective of CDT-based multimodal anticancer therapy.

Keywords: Chemodynamic therapy, Combination therapies, Tumor microenvironment, Reactive oxygen species, Nanotechnology

Citation styles

APA
Gao, H., Cao, Z., Liu, H., Chen, L., Bai, Y., Wu, Q., Yu, X., Wei, W., Wang, M. (2023). Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions. Theranostics, 13(6), 1974-2014. https://doi.org/10.7150/thno.80887.

ACS
Gao, H.; Cao, Z.; Liu, H.; Chen, L.; Bai, Y.; Wu, Q.; Yu, X.; Wei, W.; Wang, M. Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions. Theranostics 2023, 13 (6), 1974-2014. DOI: 10.7150/thno.80887.

NLM
Gao H, Cao Z, Liu H, Chen L, Bai Y, Wu Q, Yu X, Wei W, Wang M. Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions. Theranostics 2023; 13(6):1974-2014. doi:10.7150/thno.80887. https://www.thno.org/v13p1974.htm

CSE
Gao H, Cao Z, Liu H, Chen L, Bai Y, Wu Q, Yu X, Wei W, Wang M. 2023. Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions. Theranostics. 13(6):1974-2014.

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