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Volume 15 (1); 2025

Research Papers

CD63 as novel target for nanoemulsion-based ¹⁹F MRI imaging and drug delivery to activated cardiac fibroblasts Arlen Aurora Euan Martínez, Ann Kathrin Bergmann, Frederik Tellkamp, Stephan Schott-Verdugo, Pascal Bouvain, Julia Steinhausen, Jasmin Bahr, Vivien Kmietczyk, Maja Bencun, Ulrich Flögel, Jörg H. W. Distler, Marcus Krueger, Mirko Völkers, Constantin Czekelius, Holger Gohlke, Sebastian Temme, Julia Hesse, Jürgen Schrader Theranostics 2025; 15(1): 1-18. doi:10.7150/thno.96990 Full text PDF PubMed PMC

CXCR4-directed endoradiotherapy with [¹⁷⁷Lu]Pentixather added to total body irradiation for myeloablative conditioning in patients with relapsed/refractory acute myeloid leukemia Krischan Braitsch, Theo Lorenzini, Maike Hefter, Katrin Koch, Katharina Nickel, Jan C Peeken, Katharina S Götze, Wolfgang Weber, Anne Allmann, Calogero D'Alessandria, Julia Brosch-Lenz, Florian Bassermann, Martina Rudelius, Mareike Verbeek, Matthias Eiber, Peter Herhaus Theranostics 2025; 15(1): 19-29. doi:10.7150/thno.101215 Full text PDF PubMed PMC

Revolutionizing drug delivery: low-intensity pulsed ultrasound (LIPUS)-driven deep penetration into hypoxic tumor microenvironments of cholangiocarcinoma Sera Hong, Jaihwan Kim, Gujin Chung, Donghyuk Lee, Joon Myong Song Theranostics 2025; 15(1): 30-51. doi:10.7150/thno.99981 Full text PDF PubMed PMC

Optical molecular imaging in oral- and oropharyngeal squamous cell carcinoma using a novel uPAR-targeting near-infrared imaging agent FG001 (ICG-glu-glu-AE105): An explorative phase II clinical trial Amanda Oester Andersen, Anders Christensen, Karina Straede, Mads Lawaetz, Christoffer Holst Hahn, Nicklas Rubek, Irene Wessel, Giedrius Lelkaitis, Katalin Kiss, Natasja Paaske, Anne Poulsen, Christian von Buchwald, Andreas Kjaer Theranostics 2025; 15(1): 52-67. doi:10.7150/thno.100042 Full text PDF PubMed PMC

Integrating oxygen-boosted sonodynamic therapy and ferroptosis via engineered exosomes for effective cancer treatment Mingbo Wu, Zhanlin Zhang, Dong Li, Xiaomiao Ruan, Jingwen Yang, Siyi Chen, Xin Li, Wenwu Ling Theranostics 2025; 15(1): 68-85. doi:10.7150/thno.102977 Full text PDF PubMed PMC

iRGD-TRP-PK1-modified red blood cell membrane vesicles as a new chemotherapeutic drug delivery and targeting system in head and neck cancer Suwen Bai, Zunyun Wang, Yuxin Zhang, Yunyun Yang, Yuan Wei, Yumei Luo, Minghua Wang, Bing Shen, Wei He, Zhenye Yang, Hui Hui, Juan Du Theranostics 2025; 15(1): 86-102. doi:10.7150/thno.99481 Full text PDF PubMed PMC

Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma Xuekun Fu, Jie Huang, Xinxin Chen, Duoli Xie, Hongzhen Chen, Zhijian Liang, Zhuqian Wang, Yiying Liang, Aiping Lu, Chao Liang Theranostics 2025; 15(1): 103-121. doi:10.7150/thno.99588 Full text PDF PubMed PMC

18F-5-fluoro-aminosuberic acid PET/CT imaging of oxidative-stress features during the formation of DEN-induced rat hepatocellular carcinoma Feng Xiong, Yilin Yang, Zhengru Han, Buchuan Zhang, Kijung Kwak, Pei Wang, Qiaorong Chen, Ziqiang Wang, Jingfei Yang, Xiaoyun Deng, Sijuan Zou, Zhuoli Zhang, Pengtao You, Bo Yu, Xiaohua Zhu Theranostics 2025; 15(1): 141-154. doi:10.7150/thno.100467 Full text PDF PubMed PMC

A H2S-activated NIR-II imaging probe for precise diagnosis and pathological evaluation of colorectal tumor Yu Ji, Qinxian Huang, Qian Jia, Haohao Yan, Yajing Chi, Yuanyuan Jia, Chaoqiang Qiao, Yanbin Feng, Zuo Yang, Ruili Zhang, Zhongliang Wang Theranostics 2025; 15(1): 189-201. doi:10.7150/thno.103999 Full text PDF PubMed PMC

Big data analytics and scRNA-seq in human aortic aneurysms and dissections: role of endothelial MerTK Shijie Liu, Jinzi Wu, Oishani Banerjee, Bingzhong Xue, Hang Shi, Zufeng Ding Theranostics 2025; 15(1): 202-215. doi:10.7150/thno.103851 Full text PDF PubMed PMC

Tumor immunomodulation by nanoparticle and focused ultrasound alters gut microbiome in a sexually dimorphic manner Akansha Singh, Sri Vidhya Chandrasekar, Vishnu Thayil Valappil, Joy Scaria, Ashish Ranjan Theranostics 2025; 15(1): 216-232. doi:10.7150/thno.99664 Full text PDF PubMed PMC

First clinical utility of sensing Ultrasound Localization Microscopy (sULM): identifying renal pseudotumors Sylvain Bodard, Louise Denis, Georges Chabouh, Dany Anglicheau, Olivier Hélénon, Jean-Michel Correas, Olivier Couture Theranostics 2025; 15(1): 233-244. doi:10.7150/thno.100897 Full text PDF PubMed PMC

Inhibiting autophagy selectively prunes dysfunctional tumor vessels and optimizes the tumor immune microenvironment Wanting Hou, Chaoxin Xiao, Ruihan Zhou, Xiaohong Yao, Qin Chen, Tongtong Xu, Fujun Cao, Yulin Wang, Xiaoying Li, Ouying Yan, Xiaolin Ai, Cheng Yi, Dan Cao, Chengjian Zhao Theranostics 2025; 15(1): 258-276. doi:10.7150/thno.98285 Full text PDF PubMed PMC

A STING agonist prodrug reprograms tumor-associated macrophage to boost colorectal cancer immunotherapy Aohua Deng, Renming Fan, Yongrui Hai, Junyan Zhuang, Bingjie Zhang, Xintong Lu, Wenhui Wang, Li Luo, Ge Bai, Lei Liang, Le Yang, Minggao Zhao, Gaofei Wei Theranostics 2025; 15(1): 277-299. doi:10.7150/thno.101001 Full text PDF PubMed PMC

Reviews

Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science Luyao Yang, Pengyu Chen, Xiaofei Wen, Qingliang Zhao Theranostics 2025; 15(1): 122-140. doi:10.7150/thno.97192 Full text PDF PubMed PMC

Metabolism of cancer cells and immune cells in the initiation, progression, and metastasis of cancer Mingxia Jiang, Huapan Fang, Huayu Tian Theranostics 2025; 15(1): 155-188. doi:10.7150/thno.103376 Full text PDF PubMed PMC

tRNA-derived small RNAs in disease immunity Hongyuan Jia, Linling Zhang Theranostics 2025; 15(1): 245-257. doi:10.7150/thno.102650 Full text PDF PubMed PMC

Targeting cancer with precision: strategical insights into TCR-engineered T cell therapies Pei Lin, Yunfan Lin, Zizhao Mai, Yucheng Zheng, Jiarong Zheng, Zihao Zhou, Xinyuan Zhao, Li Cui Theranostics 2025; 15(1): 300-323. doi:10.7150/thno.104594 Full text PDF PubMed PMC

Leveraging plant-derived nanovesicles for advanced nucleic acid-based gene therapy Meihong Chai, Bowen Gao, Shihua Wang, Liping Zhang, Xing Pei, Baosen Yue, Xueyan Zhen, Mingzhen Zhang Theranostics 2025; 15(1): 324-339. doi:10.7150/thno.104507 Full text PDF PubMed PMC

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