Theranostics
ISSN: 1838-7640
Global reach, higher impact
Volume 15 (9); 2025
Research Papers
In vivo molecular imaging of breast cancer metabolic heterogeneity using [1-13C]pyruvate-d3 hyperpolarized by reversible exchange with parahydrogen
Stefan Petersen, Luca Nagel, Philipp R. Groß, Henri de Maissin, Robert Willing, Lisa Heß, Julia Mitschke, Nicole Klemm, Judith Treiber, Christoph A. Müller, Stephan Knecht, Ilai Schwartz, Moritz Weigt, Michael Bock, Dominik von Elverfeldt, Maxim Zaitsev, Eduard Y. Chekmenev, Jan-Bernd Hövener, André F. Martins, Franz Schilling, Thomas Reinheckel, Andreas B. Schmidt
Theranostics 2025; 15(9): 3714-3723. doi:10.7150/thno.103272
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Visceral metastases, platelet dynamics, and PSA decline: from biomarkers to better outcomes in [177Lu]Lu‑PSMA‑617 therapy in metastatic castration-resistant prostate cancer
Nathan Poterszman, Cécile Hammer-Lefevre, Clémence Porot, Julien Salvadori, Philippe Barthélémy, François Somme
Theranostics 2025; 15(9): 3724-3732. doi:10.7150/thno.109860
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A multifunctional injectable microsphere with enhanced near-infrared photo-antibacterial, ROS scavenging, and anti-inflammatory properties for periodontitis treatment
Ziliang Xiu, Yujing Zhu, Xiaofeng Li, Xiaoxi Jiang, Yunru Feng, Li He, Chunhui Li, Rui Cai, Gang Tao
Theranostics 2025; 15(9): 3750-3780. doi:10.7150/thno.107793
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Acetylation-regulated DUSP1 deficiency contributes to renal fibrosis progression
Shaobo Wang, Bo Zhang, Yaqin Wang, Qigang Lan, Liangjing Lv, Tangli Xiao, Yan Li, Mengying Yao, Jun Zhang, Cheng Wang, Yinghui Huang, Jinghong Zhao, Jiachuan Xiong
Theranostics 2025; 15(9): 3781-3796. doi:10.7150/thno.108992
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A “CPApoptosis” nano-actuator switches immune-off solid tumors to immune-on for fueling T-cell- based immunotherapy
Ying Luo, Yi Wang, Bo Liu, Yun Liu, Wenli Zhang, Sijin Chen, Xiyue Rong, Lian Xu, Qianying Du, Jia Liu, Jie Xu, Haitao Ran, Zhigang Wang, Dajing Guo
Theranostics 2025; 15(9): 3797-3820. doi:10.7150/thno.105867
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Investigating the relationships of structural and functional neural networks of primary visual cortex with engineered AAVs and chemogenetic-fMRI techniques
Zhu Gui, Kunzhang Lin, Nengsong Luo, Zengpeng Han, Zhuang Liu, Ziyue Zhao, Lei Gu, Fanyong Xu, Ning Zheng, Fuqiang Xu, Xihai Li, Jie Wang
Theranostics 2025; 15(9): 3821-3836. doi:10.7150/thno.109625
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Neural-enhancing PRP/Alg/GelMA triple-network hydrogel for neurogenesis and angiogenesis after spinal cord injury via PI3K/AKT/mTOR signaling pathway
Zhihe Yun, Jiuping Wu, Xinzhi Sun, Tao Yu, Wu Xue, Anyuan Dai, Tianyang Yuan, Xuhao Yang, Inbo Han, Yanting Liu, Wenlong Song, Qinyi Liu
Theranostics 2025; 15(9): 3837-3861. doi:10.7150/thno.109091
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A carrier-free long-acting ropivacaine formulation using methylprednisolone sodium succinate as a dual-functional adjuvant
Weiwei Wu, Yan Wang, Feng Qiu, Yingxian Dong, Jing Liu, Yujun Zhang, Deying Gong, Yi Kang, Guoyan Zhao, Congyan Liu, Yuncheng Li, Tao Zhu, Wensheng Zhang, Guowei Che
Theranostics 2025; 15(9): 3862-3876. doi:10.7150/thno.107397
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An anti-FAP-scFv-functionalized exosome-carrying hydrogel delivers SKI mRNA to fibrotic nucleus pulposus cells to alleviate intervertebral disc degeneration by regulating FOXO3
Yueyang Li, Yu Zhai, Tianling Wang, Siya Wang, Yu Tian, Zhiqun Bian, Yang Zhang, Chao Zhang, Minghan Liu, Changqing Li
Theranostics 2025; 15(9): 3877-3899. doi:10.7150/thno.107776
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A distinct subgroup with Schwann-like differentiation presents immune resistance and poor prognosis in plantar melanoma
Jie Tian, Lu Zhang, Le Zhuang, Pingping Lin, Shenxi Zhang, Yicen Yan, Yu Yang, Guohong Zhang, Hang Li, Binbin Lai
Theranostics 2025; 15(9): 3900-3923. doi:10.7150/thno.99526
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Designing multifunctional recombinant vaccines: an engineering strategy based on innovative epitope prediction-guided splicing
Zhidong Wang, Xiaolin Yang, Xiaoyi Wei, Licai Shi, Xuechun Wang, Zhenjian Zhuo, Hailong Su, Wengao Wu, Yu J. Cao
Theranostics 2025; 15(9): 3924-3942. doi:10.7150/thno.103755
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Drugless peptide-based nanohybrids alleviate diabetic retinopathy by suppressing microglial activation and endothelial inflammation
Mei Du, Xiao Zhao, Miao Guo, Xiaoyu Wang, Yutian Zhang, Linshan Yang, Sixia Liu, Liya Sun, Mengyu Liao, Xue Dong, Yi Lei, Yumeng Zhao, Shuqi Liang, Xiaohong Wang, Caiyun You, Hong Yang, Hua Yan
Theranostics 2025; 15(9): 3943-3960. doi:10.7150/thno.102775
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Photoactivatable immunomodulator polyprodrugs for boosting synergistic antitumor immunity of STING agonists and IDO inhibitors
Guopu Huang, Cheng Li, Jiale Si, Yufei Cao, Moujiang Zheng, Yueming Xue, Qinghao Zhou, Zhishen Ge, Yuanyuan Ji
Theranostics 2025; 15(9): 3979-3994. doi:10.7150/thno.107774
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Hybrid NIR-responsive liposome/hydrogel platform mediating chemo-photothermal therapy of retinoblastoma enhanced by quercetin as an adjuvant
Min Lin, Xiumei Liu, Jing Li, Hong Zou, Jie Wang, Zi Yan, Ying Liu, Yaqi Lyu, Nianping Feng
Theranostics 2025; 15(9): 3995-4015. doi:10.7150/thno.108471
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Augmented expression of superoxide dismutase 2 mitigates progression and rupture of experimental abdominal aortic aneurysm
Huimin Yan, Ying Hu, Yang Lyu, Antonina Akk, Angela C. Hirbe, Samuel A. Wickline, Hua Pan, Elisha D.O. Roberson, Christine T.N. Pham
Theranostics 2025; 15(9): 4016-4032. doi:10.7150/thno.104957
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Hepatic stellate cell-derived microfibrillar-associated protein 2 prevents liver fibrosis by regulating extracellular matrix and inflammation
Wen Zhang, Wenyue Wu, Ning Zhang, Hong Li, Yameng Sun, Xiaodong Ge, Hui Han, Shuyan Chen, Anjian Xu, Sai Santosh Babu Komakula, Chao Wang, Nithyananthan Subramaniyam, Qi Han, Aiting Yang, Xuzhen Yan, Natalia Nieto, Hong You, Wei Chen
Theranostics 2025; 15(9): 4033-4053. doi:10.7150/thno.109771
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A self-healing radiopaque hyaluronic acid hydrogel as a new injectable biomaterial for precision medicine in osteoarthritis
Moustoifa Said, Clément Tavakoli, Chloé Dumot, Karine Toupet, Cécile Olivier, Alexia Gilles, Marie Maumus, Yuxi Clara Dong, Nora Collomb, Céline Auxenfans, Anaïck Moisan, Bertrand Favier, Benoit Chovelon, Emmanuel Luc Barbier, David Peter Cormode, Emmanuel Brun, Hélène Elleaume, Marlène Wiart, Olivier Detante, Claire Rome, Danièle Noël, Rachel Auzély-Velty
Theranostics 2025; 15(9): 4054-4073. doi:10.7150/thno.104551
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Transcranial ultrasound localization microscopy in moyamoya patients using a clinical ultrasound system
Louise Denis, Elena Meseguer, Augustin Gaudemer, Georges Jaklh, Sylvain Bodard, Georges Chabouh, Dominique Hervé, Eric Vicaut, Pierre Amarenco, Olivier Couture
Theranostics 2025; 15(9): 4074-4083. doi:10.7150/thno.105427
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Modulation of comorbid depression of neuropathic pain by dopamine input from VTA to the ventral hippocampus
Yuanyuan Ji, Yifan Xiao, Xiaoyan Bai, Junxiang Gu, Teng Ma, Yue Feng, Jian Wang, Yupeng Feng, Tao Chen, Jianghua Lai, Juan Shi, Jinlian Li
Theranostics 2025; 15(9): 4101-4123. doi:10.7150/thno.104394
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Dual targeting PET tracer [68Ga]Ga-PSFA-01 in patients with prostate cancers: A pilot exploratory study
Yue Li, Lili Guan, Xiaoyang Zhang, Jia Li, Xinlin Wang, Wenbo Li, Lu Xu, Shuang Liu, Zhaobing Tang, Mengchao Cui, Hua Pang
Theranostics 2025; 15(9): 4124-4134. doi:10.7150/thno.108676
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Free glutaraldehyde gelatin microsphere loaded mesenchymal stem cells alleviate osteoarthritis by promoting Ext1 expression
Ye Yuan, Longsheng Xu, Yu Zhao, Tizhen Yan, Baobiao Zhuo, Fan Bu, Qian Cai, Youjia Xu, Qing Bi, Yu Tong, Dan Xing, Di Sun, Jianhao Lin
Theranostics 2025; 15(9): 4135-4146. doi:10.7150/thno.109468
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Reviews
Phenylboronic acid in targeted cancer therapy and diagnosis
Mila Radan, Ivana Carev, Mladen Miloš, Marina Tranfić Bakić
Theranostics 2025; 15(9): 3733-3749. doi:10.7150/thno.104558
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Mechanisms and novel therapeutic roles of bitter taste receptors in diseases
Aiyang Tong, Hongyu Yang, Xiaohui Yu, Dongkai Wang, Jian Guan, Ming Zhao, Ji Li
Theranostics 2025; 15(9): 3961-3978. doi:10.7150/thno.107406
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Therapeutic potential of FAPI RLT in oncology: A systematic review
Saad Ruzzeh, Ahmed Saad Abdlkadir, Diana Paez, Keon W. Kang, Tadashi Watabe, Serin Moghrabi, Andrew M. Scott, Akram Al-Ibraheem
Theranostics 2025; 15(9): 4084-4100. doi:10.7150/thno.106108
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Erratum
Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction: Erratum
Qun Liu, Fei-Ge Zhang, Wen-Song Zhang, An Pan, Yi-Lin Yang, Jin-Feng Liu, Ping Li, Bao-Lin Liu, Lian-Wen Qi
Theranostics 2025; 15(9): 3713. doi:10.7150/thno.104739
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