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Theranostics 2011; 1:230-239. doi:10.7150/thno/v01p0230 This volume Cite

Research Paper

Photosensitizer-Conjugated Human Serum Albumin Nanoparticles for Effective Photodynamic Therapy

Hayoung Jeong1,2 *, MyungSook Huh1 *, So Jin Lee1, Heebeom Koo1, Ick Chan Kwon1, Seo Young Jeong2 ✉, Kwangmeyung Kim1 ✉

1. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Haweolgog-Dong, Sungbook-Gu, Seoul 136-791, Korea.
2. Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Korea.
* These authors contributed equally to this paper.

✉ Corresponding author: Kwangmeyung Kim, PhD, KIST, Biomedical Research Center, Haweolgog-Dong, Sungbook-Gu, Seoul 136-791, Korea. Tel: +82 2 958 5916; Fax: +82 2 958 5909. E-mail: kimre.kr. Seo Young Jeong, PhD, Kyung Hee University, Department More

Citation:
Jeong H, Huh M, Lee SJ, Koo H, Kwon IC, Jeong SY, Kim K. Photosensitizer-Conjugated Human Serum Albumin Nanoparticles for Effective Photodynamic Therapy. Theranostics 2011; 1:230-239. doi:10.7150/thno/v01p0230. https://www.thno.org/v01p0230.htm
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Abstract

Photodynamic therapy (PDT) is an emerging theranostic modality for various cancers and diseases. The focus of this study was the development of tumor-targeting albumin nanoparticles containing photosensitizers for efficient PDT. To produce tumor-targeting albumin nanoparticles, the hydrophobic photosensitizer, chlorin e6 (Ce6), was chemically conjugated to human serum albumin (HSA). The conjugates formed self-assembled nanoparticle structures with an average diameter of 88 nm under aqueous conditions. As expected, the Ce6-conjugated HSA nanoparticles (Ce6-HSA-NPs) were nontoxic in their native state, but upon illumination with the appropriate wavelength of light, they produced singlet oxygen and damaged target tumor cells in a cell culture system. Importantly, when the nanoparticles were injected through the tail vein into tumor-bearing HT-29 mice, Ce6-HSA-NPs compared with free Ce6 revealed enhanced tumor-specific biodistribution and successful therapeutic results following laser irradiation. These results suggest that highly tumor-specific albumin nanoparticles have the potential to serve not only as efficient therapeutic agents, but also as photodynamic imaging (PDI) reagents in cancer treatment.

Keywords: Photodynamic therapy, Human Serum Albumin Nanoparticles

Citation styles

APA
Jeong, H., Huh, M., Lee, S.J., Koo, H., Kwon, I.C., Jeong, S.Y., Kim, K. (2011). Photosensitizer-Conjugated Human Serum Albumin Nanoparticles for Effective Photodynamic Therapy. Theranostics, 1, 230-239. https://doi.org/10.7150/thno/v01p0230.

ACS
Jeong, H.; Huh, M.; Lee, S.J.; Koo, H.; Kwon, I.C.; Jeong, S.Y.; Kim, K. Photosensitizer-Conjugated Human Serum Albumin Nanoparticles for Effective Photodynamic Therapy. Theranostics 2011, 1, 230-239. DOI: 10.7150/thno/v01p0230.

NLM
Jeong H, Huh M, Lee SJ, Koo H, Kwon IC, Jeong SY, Kim K. Photosensitizer-Conjugated Human Serum Albumin Nanoparticles for Effective Photodynamic Therapy. Theranostics 2011; 1:230-239. doi:10.7150/thno/v01p0230. https://www.thno.org/v01p0230.htm

CSE
Jeong H, Huh M, Lee SJ, Koo H, Kwon IC, Jeong SY, Kim K. 2011. Photosensitizer-Conjugated Human Serum Albumin Nanoparticles for Effective Photodynamic Therapy. Theranostics. 1:230-239.

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