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Volume 16 (9); 2026
Research Papers
Specific in vivo detection of V2R-positive metastatic ccRCC using a toxin-based PET radioligand
Goran Stanajic Petrovic, Khawla Chmeis, Alix Gonand, Ingrid Leguerney, Alexandre Ingels, Dimitri Kereselidze, Benoit Jego, Caroline Denis, Apolline Urman, Marion Chaigneau, Romain Baudat, Antoine Guyot, Pascal Kessler, Mathilde Keck, Denis Servent, Mylène Richard, Nicolas Gilles, Charles Truillet
Theranostics 2026; 16(9): 4471-4488. doi:10.7150/thno.126311
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Connective tissue growth factor contributes to resistance to anti-angiogenic therapies in renal cancer
Manon Teisseire, Arthur Karaulic, Julien Parola, Maëva Totobesola, Delphine Borchiellini, Tanguy Pace-Loscos, Renaud Schiappa, Emmanuel Chamorey, Jérôme Durivault, Maëva Dufies, Damien Ambrosetti, Frédéric Luciano, Juan Gao, Yihai Cao, Gilles Pagès, Sandy Giuliano
Theranostics 2026; 16(9): 4489-4507. doi:10.7150/thno.125269
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CAIX-targeted α therapy directed against hypoxic tumor cells in combination with immune checkpoint inhibitors in a syngeneic mouse tumor model
Sylvia T.M. Wenker, Mark W. Konijnenberg, Daphne Lobeek, Giulia Tamborino, Janneke D.M. Molkenboer-Kuenen, Gerben M. Franssen, Daan F. Boreel, Simone C. Kleinendorst, Hans Peters, Johan Bussink, Sanne A.M. van Lith, Sandra Heskamp
Theranostics 2026; 16(9): 4508-4520. doi:10.7150/thno.127288
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Open Porous Microenvironment-regulatory Microspheres Loaded with Curcumin@BSA NPs/BMSCs for Diabetic Wound Treatment
Zhe Liu, Qinzhou Zheng, Dong Zhou, Anqi Lin, Lan Xiao, Haifeng Liu, Keqin Ji, Huifen Qiang, Xinxin Sui, Yulin Li, Yan Wu, Jie Gao, Lan Liao, Xiaohuan Yuan
Theranostics 2026; 16(9): 4521-4550. doi:10.7150/thno.120285
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PSMA-targeted fluorescent probe for NIR-II imaging in prostate cancer intraoperative navigation and tumor margin mapping
Zhongji Jiang, Haozhe Tan, Bo Wu, Lin Zhang, Gaohaer Kadeerhan, Jin Zhang, Jiali Jin, Zikuan Zhang, Hong Guo, Wenmin Guo, Jiedong Jia, Jun Tian, Ben Zhong Tang, Dongwen Wang
Theranostics 2026; 16(9): 4551-4565. doi:10.7150/thno.117540
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Bacterial vesicles-initiated in-situ spray-polymerized coating enables synergistic antibacterial-photothermal functionality for accelerating wound healing
Dan Wang, Shuya Liang, Zhijuan Ai, Qian Kong, Dongming Xing, Zhenping Cao, Zhongmin Geng
Theranostics 2026; 16(9): 4566-4579. doi:10.7150/thno.126844
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C-terminal Fragment Generated by HOIL-1 Cleavage Suppresses Inflammatory Responses of Myeloid Cells to Alleviate Colitis
Xiaomeng Li, Hefan Zhang, Qian Wang, Qianqian Li, Xingru Wang, Yu Tian, Rui Zhang, Qiuyun Chen, Christopher M. Overall, Stuart E. Turvey, Bangmao Wang, Hailong Cao, Hong Yang, Shan-Yu Fung
Theranostics 2026; 16(9): 4580-4602. doi:10.7150/thno.124294
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Blocking AREG-EGFR signaling attenuates pan-arterial fibrosis in chronic cardiac allograft rejection
Kai Xing, Yuan Chang, Yuqi An, Xiao Chen, Xiaofei Zhu, Jian Huang, Peiyuan Li, Mengda Xu, Yixuan Sheng, Xingchao Du, Hao Liu, Jiangping Song
Theranostics 2026; 16(9): 4603-4618. doi:10.7150/thno.125318
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Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Social Deficits in Mice
Xiangdong Wan, Ziqian Yan, Zhaoyichun Zhang, Xueqing Liu, Dingding Yang, Ming Zhang, Haiying Liu, Jiaqi Li, Bo Yang, Rong Zheng, Yifan Lu, Jing Huang, Fan Zhang, Guohong Cai, Shengxi Wu
Theranostics 2026; 16(9): 4619-4640. doi:10.7150/thno.129482
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Development of a dendritic cell-targeted vaccine strategy using proximity-induced conjugation
Zhidong Wang, Xiaolin Yang, Jianjiang Li, Guang Chen, Haodi Ma, Zhengshuang Xu, Yu J. Cao
Theranostics 2026; 16(9): 4641-4656. doi:10.7150/thno.122332
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Systemic Interleukin-4 Application Promotes Functional Recovery and Reprograms Neuroinflammatory and Molecular Responses after Spinal Cord Injury in Rats
Obada Taleb Alhalabi, Stefan Heene, Guoli Zheng, Raban Heller, Tim Schubert, Marcin Luzarowski, Xiaowei Zha, Johannes Walter, Lea Hansen-Palmus, Bahram Biglari, Xing-Jin Wang, Laura Ruebenacker, Thomas Skutella, Karl Kiening, Christian Patrick Schaaf, Sandro Manuel Krieg, Andreas Wilhelm Unterberg, Klaus Zweckberger, Alexander Younsi
Theranostics 2026; 16(9): 4726-4744. doi:10.7150/thno.123815
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OSBPL3-driven sterol metabolic reprogramming promotes oncogenic signaling and therapeutic resistance in pancreatic cancer
Qihui Sun, Xiaojia Li, Qi Zou, Yang Chen, Xiaoqi Zhu, Hailin Jiang, Tingting Jiang, Fang Wei, Keping Xie
Theranostics 2026; 16(9): 4745-4767. doi:10.7150/thno.113637
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H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury
Yan Huang, Eryang Zhao, Guangyu Zhao, Wenfeng Zhuo, Yingsong Zhao, Hongda Wang, Guozheng Lv, Rong Hu, Zhu Zeng, Shengbo Han, Yuhang Hu, Gang Zhao
Theranostics 2026; 16(9): 4768-4786. doi:10.7150/thno.122991
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In vivo Expansion of Regulatory T cells via an Engineered IL-2 Mutein to Suppress Autoimmune Glomerulonephritis
Huang Kuang, Cai-Xia Lin, Jing Huang, Wen-Xuan Li, Yu-Ge Zhu, Nan Jiang, Zhong Li, Nan Li, Ping Li, Xiao-Yu Jia, Zhao Cui, Ming-Hui Zhao
Theranostics 2026; 16(9): 4787-4803. doi:10.7150/thno.126588
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From pathogenesis to treatment: the role of autophagic cell death in GONFH and its potential mitigation by naringenin
Huihui Xu, Haipeng Huang, Kaiao Zou, Xingfang Yu, Qinghe Zeng, Congzi Wu, Wenzhe Chen, Pinger Wang, Bangjian He, Luwei Xiao, Jiali Chen, Peijian Tong, Hongting Jin
Theranostics 2026; 16(9): 4804-4820. doi:10.7150/thno.129809
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Identification of programmed cell death-related subtypes reveals immune heterogeneity and therapeutic divergence in colon cancer
Peng Xia, Ying Qu, Quanzhong Liu, Mengyan Zhu, Bin Huang, Wei Wu, Kening Li, Lingxiang Wu, Ruohan Zhang, Yingli Lv, Qianghu Wang
Theranostics 2026; 16(9): 4821-4840. doi:10.7150/thno.126314
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Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx
Pengxiang Zhao, Han Li, Zisong Cai, Xujuan Zhang, Xiaohu Wen, Ziyi Liu, Shihao Jiang, Xue Jiang, Jiateng Wang, Zheng Dang, Mengyu Liu, Fei Xie, Xuemei Ma
Theranostics 2026; 16(9): 4843-4864. doi:10.7150/thno.124352
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CEBPB-high dormant tumor cells drive immune evasion via S100A8 orchestrated tumor-associated macrophages reprogramming
Jin Bai, Huilan Su, Shunxi Wang, Yang Dong, Yong Gao
Theranostics 2026; 16(9): 4883-4904. doi:10.7150/thno.124789
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Flow-induced Klf4-Akt signaling links EC cycling to mural cell defects in arterial-venous malformations
Yanzhu Lin, Zohrah Hashemi, Qing Zhang, Yuxi Di, Tanmaya Behera, Johannes Gahn, Kuheli Banerjee, Fan Wu, Kornelia Andorfer, Mahak Singhal, Caroline Seebauer, Roxana Ola
Theranostics 2026; 16(9): 4905-4922. doi:10.7150/thno.121154
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Bimetallic Cu/Fe-MOF-based heterojunction sonozymes for triple amplification of sono-immunotherapy through activating tumor-specific cuproptosis and cGAS-STING pathway
Xueyuan Liu, Nan Wang, Jinming Cai, Jinyan Hu, Zhenlin Zhang, Chuanqi Feng, Dengyu Pan, Bijiang Geng
Theranostics 2026; 16(9): 4923-4939. doi:10.7150/thno.130381
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Globo H ceramide confers chemoresistance and poor prognosis to advanced gallbladder cancer via A2AR/cAMP/PKA pathway
Tsai-Hsien Hung, Jung-Tung Hung, Wen-Kuan Huang, Yenlin Huang, Chiao-En Wu, Jing-Yan Cheng, Chien-Wei Lee, John Yu, Yi-Chia Wu, Chun-Nan Yeh, Alice L. Yu
Theranostics 2026; 16(9): 4940-4958. doi:10.7150/thno.126092
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Multimodal tumor thermal therapy enhances antitumor immunity by expanding tumor-reactive CX3CR1⁺GPR56⁺ T cells in hepatocellular carcinoma
Shicheng Wang, Ying Wang, Yan Zhang, Zelu Zhang, Haozhe Huang, Lichao Xu, Yuankai Hao, Yue Lou, Ke Wang, Wentao Li, Ping Liu, Lisa X. Xu, Bing Su
Theranostics 2026; 16(9): 4959-4979. doi:10.7150/thno.127962
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Reviews
Panoramic description of ROS-based nanotechnology for osteomyelitis therapy: Challenges, opportunities, and prospects
Wenqiao Wang, Xiaoying Kong, Jinsheng Shi, Ting Wang
Theranostics 2026; 16(9): 4657-4701. doi:10.7150/thno.124716
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Nanobiomaterial-enabled boron delivery systems and innovative strategies for revolutionizing BNCT
Qiyao Yang, Ruxuan Wang, Huang Lingling, Qiong Bian, Qichun Wei
Theranostics 2026; 16(9): 4702-4725. doi:10.7150/thno.126209
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Tumor metabolic plasticity in therapy resistance: from the Warburg effect to mitochondrial hijacking
Yen-Dun Tony Tzeng, Emmanuel Naveen Raj, Shih-Hsuan Cheng, Su-Boon Yong, Shih-Chieh Lin, Ren-Wang Peng, Chia-Jung Li
Theranostics 2026; 16(9): 4865-4882. doi:10.7150/thno.131708
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Recent advances of metal-organic frameworks (MOFs) for drug delivery, cancer imaging and theranostics
Honglian Yu, Gan Lin, Peng Mi
Theranostics 2026; 16(9): 4980-5015. doi:10.7150/thno.128435
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Carbon dots penetrating the blood-brain barrier for central nervous system nanomedicine
Wubshet Mekonnen Girma, Girum Getachew Demissie, Shewaye Lakew Mekuria, Shamsa Kizhepat, T.M. Subrahmanya, Akash S. Rasal, Binyam Abdu Berhe, Gangaraju Gedda, Yoo-Jin Park, Jia-Yaw Chang, Myung-Geol Pang
Theranostics 2026; 16(9): 5016-5043. doi:10.7150/thno.130380
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From bench to bedside: the promise and roadblocks of extracellular vesicle therapeutics
Jing Zhang, Yuanwei Pan, Peng She, Lang Rao
Theranostics 2026; 16(9): 5044-5064. doi:10.7150/thno.131621
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The B-cell-autoantibody axis in lung cancer immunity
Yan Huang, Haoyue Hu, Ruoyu Sun, Yi Wang
Theranostics 2026; 16(9): 5065-5084. doi:10.7150/thno.131046
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Biomimetic Cell Membrane-coated Nanovaccines in Anti-tumor Immunotherapy
Yizhang Chen, Weiyue Zhang, Xin Huang
Theranostics 2026; 16(9): 5085-5104. doi:10.7150/thno.128136
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Erratum
Macrophage membrane-functionalized nanotherapeutics for tumor targeted therapy: Erratum
Mubassir Khan, Razi Ullah, Guixue Wang, Maoquan Chu
Theranostics 2026; 16(9): 4841-4842. doi:10.7150/thno.120915
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