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Volume 16 (10); 2026
Research Papers
Host-directed nanotherapy for the treatment and imaging of tuberculous meningitis Elizabeth W. Tucker, John Kim, Clara Erice, Anjali Sharma, Nerketa N. L. Damiba, Alvaro A. Ordonez, Javier Allende Labastida, Nirnath Sah, Filipa Mota, Patricia de Jesus, Rhea Saini, Kelly F. Schiaffino, Sanjay K. Jain, Rangaramanujam M. Kannan, Sujatha Kannan
Theranostics 2026; 16(10): 5105-5124. doi:10.7150/thno.125729
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Tumor-targeted Exosomal Delivery of Celastrol for Enhanced Therapeutic Efficacy in NSCLC Disha Nagesh Moholkar, Raghuram Kandimalla, Mohd Saeed, Yaseera Arif, Neha Tyagi, Richa Singhal, Al-Hassan Kyakulaga, Amir Saeed, Margaret Wallen, Ramesh Gupta, Farrukh Aqil
Theranostics 2026; 16(10): 5125-5149. doi:10.7150/thno.125096
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Dual-ligand curcin-loaded hybrid solid lipid nanoparticles achieve durable gliosarcoma remission while preserving neuro-behavioral function Mohamed Sheikh Mohamed, Srivani Veeranarayanan, Yasushi Sakamoto, Rie Suge, Narumi Hirosawa, Aby Cheruvathoor Poulose, Toru Mizuki, Toru Maekawa
Theranostics 2026; 16(10): 5150-5174. doi:10.7150/thno.123534
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Phase I dose-escalation study of [¹⁷⁷Lu]Lu-LNC1011, a long-circulating dansyl-modified PSMA theranostics, in metastatic castration-resistant prostate cancer Jiarou Wang, Rongxi Wang, Jialin Xiang, Hongzhang Yang, Tianzhi Zhao, Feng Guo, Yingkui Liang, Zhaohui Zhu, Jingjing Zhang
Theranostics 2026; 16(10): 5175-5184. doi:10.7150/thno.128143
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Meningeal macrophages regulate fibroblasts to influence meningeal lymphatic function following traumatic brain injury Xiaoming Guo, Yueli Zhu, Shiqi Gao, Yiwen Wu, Yuan Hong
Theranostics 2026; 16(10): 5185-5203. doi:10.7150/thno.130263
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Attenuation of cGAS-STING signaling-mediated lung inflammation during infection through autophagy induction by bioactive nanodevices Mimi Pang, Xiang Wang, Zichen Song, Rujing Lin, Sixia Liu, Man Xing, Wenfei Xu, Jiameng Gong, Ying Qi, Mei Du, Yonghao Yu, Bing Chen, Shan-Yu Fung, Dongming Zhou, Hong Yang
Theranostics 2026; 16(10): 5204-5225. doi:10.7150/thno.127113
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Engineering inertial flow patterns for signal amplification in disc-based protein assays Hyun-Kyung Woo, Lauren Philp, Dae-Han Jung, Dominique Zarrella, Yein Chung, Yoonjeong Choi, Jueun Jeon, Hyunho Kim, Cesar M. Castro, Bo R. Rueda, Hakho Lee
Theranostics 2026; 16(10): 5226-5239. doi:10.7150/thno.124439
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Tailorable porous collagen hydrogels as a physiologically relevant platform for extrachromosomal DNA-associated colorectal cancer research Seoyul Jo, Jiwon Shon, Seohyeon An, Yoonjoo Nam, Dongwon Choi, Seungmi Lee, Hoigi Seo, Se Young Chun, Hoon Kim, GeunHyung Kim
Theranostics 2026; 16(10): 5240-5258. doi:10.7150/thno.128574
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Near-infrared light-activated lidocaine microneedle patch for rapid local anesthesia Shuailei Wang, Ze Qiang Zhao, Yumiao He, Bo Zhi Chen, Hongju Liu, Xin Dong Guo, Yuguang Huang
Theranostics 2026; 16(10): 5259-5277. doi:10.7150/thno.129132
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Lipoic acid-engineered nanodroplets for multimodal imaging and enhanced sonodynamic therapy in melanoma treatment Ziyao Wang, Yongchao Yao, Ziyan Feng, Yulong Liao, Liyun Wang, Xueyang Xiao, Wenchuang Hu, Zhiyong Qian, Li Qiu
Theranostics 2026; 16(10): 5278-5295. doi:10.7150/thno.127554
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Bioadhesive and hemostatic microneedles integrated with NIR-responsive Ti3C2/CeO2 heterojunction nanozymes for accelerated diabetic wound healing Zesheng Chen, Zhengyao Zhang, Lingfeng Tu, Guanyi Wang, Wang Wang, Ziqiang Xu, Feng Yu, Yinsuo Jia, Zijian Wang, Kanghong Hu, Weikang Hu
Theranostics 2026; 16(10): 5296-5318. doi:10.7150/thno.130627
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Lung dysbiosis disrupts an FFAR2-mediated innate immune circuit against Klebsiella pneumoniae Ting-Chieh Huang, Jheng-Syuan Shao, Alan Chuan-Ying Lai, Ko-Chien Wu, Da-Fu Lin, Ya-Jen Chang
Theranostics 2026; 16(10): 5348-5369. doi:10.7150/thno.131136
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Anti-cancer immune priming with β-radioligand therapy using a novel high affinity antibody selectively targeting the 4Ig-Isoform of B7-H3 Sarah E. Glazer, Margie N. Sutton, Ping Yang, Federica Pisaneschi, Manu Sebastian, Seth T. Gammon, David Piwnica-Worms
Theranostics 2026; 16(10): 5370-5392. doi:10.7150/thno.123285
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Ganglioside enhances the immunogenicity of nanoparticles displaying short synthetic tumor neoepitopes and epitopes Shiqi Zhou, Yuan Luo, Maarten K Nijen Twilhaar, Wei-Chiao Huang, Amal Seffouh, Yiting Song, Yafei Su, Breandan Quinn, Yun Wu, Sriram Neelamegham, Joaquin Ortega, Joke M.M. den Haan, Jonathan F Lovell
Theranostics 2026; 16(10): 5393-5405. doi:10.7150/thno.128187
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Context-dependent Activities of Mitrephorone Link Lipid Redirection, Anti-inflammatory Action, and Ferroptosis Control to Hepatocyte Protection Lorenz Waltl, Lukas A. Wein, Leonhard Bereuter, Fengting Su, Henriett Barta, Loc Le Xuan, David Holubek, Zahra Mahmoudi Eshkaftaki, Katharina Puskac, Anita Siller, Peter Schlenke, Harald Schennach, Eva-Maria Pferschy-Wenzig, Hans Schött, Silvia Racedo, Solveigh C. Koeberle, Thomas Magauer, Andreas Koeberle
Theranostics 2026; 16(10): 5406-5439. doi:10.7150/thno.127100
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Voxel-accurate MRI-microscopy Correlation Enables AI-powered Prediction of Brain Disease States Julian Schroers, Yvonne Yang, Ekin Reyhan, Nirosan Sivapalan, Einar Ismail-Zade, Alina Heuer, Jonas G. Scheck, Atefeh Pourkhalili Langeroudi, Obada T. Alhalabi, Tara Moghiseh, Manuel Fischer, David Batra, Johann Jende, Felix Sahm, Bogdana Suchorska, Franziska Maria Ippen, Dieter Henrik Heiland, Matthia A. Karreman, Franz L. Ricklefs, Michael O. Breckwoldt, Felix T. Kurz, Varun Venkataramani
Theranostics 2026; 16(10): 5440-5462. doi:10.7150/thno.125235
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Cholesterol sulfate replenishment rejuvenates aged hematopoietic stem cell phenomes Yunyu Feng, Ning Li, Nan Wang, Wei He, Hongjian Li, Xue Cui, Bochuan Wang, Runkuan Qin, Huandi Qiu, Qiang Qiu, Li Zheng, Yuanyuan Sun, Linye He, Cong Pan, Anping Su, Zhihui Li, Yiguo Hu
Theranostics 2026; 16(10): 5501-5517. doi:10.7150/thno.126134
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Synergistic nanomedicine overcomes hypoxia-driven DNA repair to potentiate radiotherapy for lung adenocarcinoma Zhichang Liu, Yue Qiu, Jie Chen, Jue Li, Cheng Zhuang, Qiyi Feng, Jinxing Huang, Chunxiu Xiao, Xiuli Zheng, Kui Luo, Kai Xiao
Theranostics 2026; 16(10): 5518-5536. doi:10.7150/thno.132916
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ELAPOR1 regulates VPS54-mediated GARP complex formation and proacrosomal vesicle fusion during spermatogenesis Chen Ding, Tingting Liang, Mina Yang, Lingbin Wang, Xuying Yin, Guoming Li, Zhaoxiang Wang, Jiahui Guo, Lin Zhang, Jie Yang, Xiaoyu Xia, Yanyan Xu, Junling Liu, Haojie Jiang
Theranostics 2026; 16(10): 5571-5588. doi:10.7150/thno.131535
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Macrophage membrane-biomimetic cinnamaldehyde nanomedicine ameliorates inflammatory bowel disease by suppressing macrophage M1 polarization Zebin Huang, Lingna Xie, Qi Shu, Yongyu Xu, Xiao-Chun Guo, Shimin Wang, Shuyi Li, Yaoxun Zeng, Xiu-Cai Chen, Mingtao Huang, Fujun Jin, Yu-Jing Lu
Theranostics 2026; 16(10): 5589-5608. doi:10.7150/thno.124748
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One-step knock-in CAR constructs in human NK cells enable scalable, TGFβ1-resistant immunotherapy for solid tumors Su-Min Yee, Ji Hye Jeong, Daeun Kim, Sung-Bae Kang, Hanna Yoon, Hyein Cho, Daechan Park, Eunsung Jun, Mihue Jang
Theranostics 2026; 16(10): 5609-5629. doi:10.7150/thno.127565
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Photothermal-driven multifunctional injectable hydrogel platform for promoting diabetic bone defect repair through synergistic immunomodulation and bone homeostasis Yufan Zhu, Huifan Liu, Zhiqiang Yang, Yaxing He, Ping Wu, Lin Cai, Lufeng Yao, Xiaobin Zhu, Minhao Wu
Theranostics 2026; 16(10): 5630-5684. doi:10.7150/thno.130240
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Discovery of a novel Nrf2 activator that modulates mitochondrial function in neurons by regulating DHRS3-Nrf2 interaction after ischemic stroke Xiaohui Sun, Zhaofeng Liu, Huanhuan An, Hengwei Xu, Fangxia Zou, Jing Lu, Xiaofan Zhang, Xinyu Han, Ziwei Song, Yanli Sun, Wenyan Wang, Hongbo Wang, Jianzhao Zhang, Yunjie Wang, Jingwei Tian
Theranostics 2026; 16(10): 5713-5740. doi:10.7150/thno.128602
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Engineering Tfh-Specific Nanoadjuvant to Counteract Bile Acid-Induced Mitophagy and Vaccine Hyporesponsivenes Huimin Wu, Zhigang Zheng, Haifeng Chen, Jinchuan Liu, Xiandong Zeng, Xiaochun Huang, Xu Fang, Junlin Zhu, Yuanjia Tang, Jun Deng, Qiang Xia, Feng Xue
Theranostics 2026; 16(10): 5741-5758. doi:10.7150/thno.125668
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Triple-Targeted DNA Nanozyme Executes Disulfidptosis for Glioma Elimination Tiantian Wu, Le Li, Shun Zhang, Guannan Zhang, Chen Li, Jiaming Mei, Xiaoyuan Chen, Junjie Cheng
Theranostics 2026; 16(10): 5759-5769. doi:10.7150/thno.133314
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Biomimetic ECM collagen hydrogel induces chondrogenic differentiation of BMSCs by activating autophagy through POU5F1-mediated AMPK/mTOR signaling pathway Xiao Ru, Zhongwen Yu, Jun Li, Fuben Xu, Guojie Xu, Junqi Xie, Simeng Yu, Pan Hu, YuanYuan Liu, Li Zheng, Jinmin Zhao, Zhenhui Lu
Theranostics 2026; 16(10): 5770-5787. doi:10.7150/thno.126710
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Reviews
Cell-drug conjugates: a novel drug delivery system for cancer therapy Xiaoli Cheng, Mengyuan He, Yuanye Zeng, Aixue Li, Lianghao Yuan, Yongwei Gu, Haiqiang Jiang, Jiyong Liu
Theranostics 2026; 16(10): 5319-5347. doi:10.7150/thno.127171
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Translational Models for Glioblastoma: Revolutionizing Drug Development and Personalized Medicine Through Clinical Insights Gaeun Lee, Yu Jin Kim, Sharon Jeeho Ham, Hyeongjin Ahn, Dayeong Choi, Juhyeong Ha, Jungseub Lee, Hyung-Jin Lee, Jaejoon Lim, Jungho Ahn
Theranostics 2026; 16(10): 5463-5500. doi:10.7150/thno.126324
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Advancements in nanomedicine for the therapeutic regulation of efferocytosis: opportunities and challenges Zehuan Lin, Xiyue Zhou, Shuyun Liu, Meihua Wan, Jingping Liu
Theranostics 2026; 16(10): 5537-5570. doi:10.7150/thno.128155
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Sensitization strategy for sonodynamic therapy Sinong Li, Ziyi Yang, Ying Zhang, Genyuan Zhang, Zoujuan Cai, Yihan Xie, Zhiqun Bai, Jin Sun, Hongzan Sun, Zhiguang Chen, Liang Sang
Theranostics 2026; 16(10): 5685-5712. doi:10.7150/thno.130498
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