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Volume 16 (7); 2026
Research Papers
Imaging CRISPR-edited CAR-T cell therapies with optical and positron emission tomography reporters Rafael Enrique Sanchez-Pupo, John Joseph Kelly, Nourhan Shalaby, Ying Xia, Francisco Manuel Martinez-Santiesteban, Jasmine Lau, Ivy Elizabeth Verriet, Matthew Stefan Fox, Justin Wesley Hicks, Jonathan Dale Thiessen, John Andrew Ronald
Theranostics 2026; 16(7): 3227-3245. doi:10.7150/thno.119013
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Tumor cell FAP orchestrates EMT and immune suppression in aggressive localized ccRCC Teijo Pellinen, Lassi Luomala, Kalle E Mattila, Annabrita Hemmes, Katja Välimäki, Mariliina Arjama, Oscar Brück, Lassi Paavolainen, Elisa Kankkunen, Harry Nisén, Petrus Järvinen, Leticia Castillon, Sakari Vanharanta, Paula Vainio, Olli Kallioniemi, Panu M. Jaakkola, Tuomas Mirtti
Theranostics 2026; 16(7): 3246-3262. doi:10.7150/thno.118400
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Hilnc-mediated UCP1 translation repression contributes to thermogenesis and energy expenditure Man Jiang, Yu Li, Yiao Jiang, Runze Wang, Jiayin Peng, Yuang Wang, Zhen Qu, Yi Chang, Zhao Zhang, Yun Zhao
Theranostics 2026; 16(7): 3263-3285. doi:10.7150/thno.122688
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Enhancing prestin oligomerization for superior sonogenetics Hsien-Chu Wang, Thi-Nhan Phan, Tzu-Han Chen, Yun Lin, Ning Hsu, Ching-Hsiang Fan, Po-Han Chiang, Chun-Hao Chen, Chih-Kuang Yeh, Yu-Chun Lin
Theranostics 2026; 16(7): 3321-3337. doi:10.7150/thno.122468
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Targeting the FOSL1/IKKα positive feedback loop attenuates glioblastoma malignancy via suppression of NF-κB signaling Beichen Zhang, Hao Tian, Haoyu Zhou, Yichang Wang, Ke Gao, Yiyang Cao, Mingjing Zhou, Maode Wang, Wei Wu, Jia Wang
Theranostics 2026; 16(7): 3338-3362. doi:10.7150/thno.121770
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Macrophage-biomimetic nanomedicine for targeted therapy of abdominal aortic aneurysm via Nrf2/NF-κB pathway Qiujie Luo, Wei Meng, Jiahui Wang, Xiang Zhang, Qingbo Meng, Mengjie Hu, Shunbo Wei, Xiaobo Yu, Dawei Deng, Yuqin Zhang, Zixuan Ma, Shentao Li, Shuang Wang, Binhao Zhang, Jingli Ding, Jinping Liu, Jianliang Zhou
Theranostics 2026; 16(7): 3363-3383. doi:10.7150/thno.123428
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Nanobody Nb07 mitigates sepsis by blocking the PFKM-p53-PD-1 axis to enhance macrophage phagocytosis Binbin Ji, Hui Guo, Rong Xing, Miaomiao Sun, Yu Cheng, Chen Yao, Hanyong Zhu, Xuerong Wang, Ruihan Jiang, Xin Chen, Zimeng Liu, Suyan Wang, Fei Xu, Fangyu Zhang, Fuxing Dong, Xiucheng Pan, Jing Yang, Yuchen Pan
Theranostics 2026; 16(7): 3408-3425. doi:10.7150/thno.124303
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Tumor microbiome-transcriptome crosstalk identifies Prevotella as an immunotherapeutic predictor in NSCLC Na Wang, Lifang Ma, Yugang Huang, Xionghui Zhou, Yuan Rong, Fei Long, Wanbo Qiu, Si Wu, Yue Hu, Xin He, Jiurong He, Sufang Tian, Weidong Hu, Chunhui Yuan, Fubing Wang
Theranostics 2026; 16(7): 3426-3446. doi:10.7150/thno.126091
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PLK1 stabilizes β-catenin to drive colorectal carcinogenesis through NFKB2-mediated transcriptional activation of USP2a and site-specific phosphorylation Yan Li, Lili Zhao, Jiaqiang Deng, Songmei Lu, Jingyu Du, Chen Chen, Li Zhao, Zhiyun Xu, Wencan Wang, Yundi Wang, Fangdong Zou
Theranostics 2026; 16(7): 3488-3506. doi:10.7150/thno.122368
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Autocrine activity of engineered IL-33 mRNA enhances adoptive T-cell therapy for peritoneal carcinomatosis and synergizes with IL-12 mRNA Leire Arrizabalaga, Claudia Augusta Di Trani, Celia Gomar, Daniel Moreno-Luqui, Nuria Ardaiz, Virginia Belsue, José González-Gomariz, David Ruiz-Guillamon, Aline Risson, Yufei Zheng, Eduardo Huarte, Ignacio Matos, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Theranostics 2026; 16(7): 3541-3555. doi:10.7150/thno.122132
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Characterization and validation of a bone metastatic castration-resistant prostate cancer model as a nanomedicine evaluation platform Antoni Serrano-Martí, Ana Armiñán, Inmaculada Conejos-Sánchez, Daniela Mittermüller, Shang-Wei Li, Paula Tenhaeff Lackschewitz, Esther Roselló-Sastre, Matthias Gunzer, Horacio Cabral, María J. Vicent
Theranostics 2026; 16(7): 3556-3576. doi:10.7150/thno.123005
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Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion Yi-Fan Zhou, Si-Bo Yang, Feng Zhang, Xiao-Di Sun, Bo-Hao Chang, Ya-Nan Li, Jie-Hong Wu, Hui-Juan Jin, Ming Huang, Sheng-Cai Chen, Hang Yang, Dong-Ya Zhu, Bijoy K Menon, Bo Hu
Theranostics 2026; 16(7): 3577-3598. doi:10.7150/thno.127083
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Coupling proteostasis and de novo purine biosynthesis of PSMD14 fuels glioblastoma progression and chemoresistance Jiazheng Wang, Qun Cao, Zhikai Li, Xuxiu Lu, Zhuo Li, Chenghui Guo, Yuan Pan, Qing Zhang, Wenjie Li, Guo Xiang, Anjing Chen
Theranostics 2026; 16(7): 3599-3615. doi:10.7150/thno.124409
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Polydopamine nanoparticles restore cognition via targeted dopamine delivery and septo-hippocampal cholinergic activation Pan-Miao Liu, Yu-Ge Wang, Ting-Ting Zhu, Ji-Chun Zhang, Han-Wen Gu, Hui-Juan Li, Wei-Tong Pan, Yan-Bo Zhou, Kui-Cheng Zhu, Kenji Hashimoto, Jian-Jun Yang
Theranostics 2026; 16(7): 3616-3633. doi:10.7150/thno.121735
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T lymphocyte membrane bionic nanomedicine synergizes with radiotherapy for enhancing Mg2+-mediated tumor metallo-immunotherapy and preventing recurrence Yongjian Zhang, Shijian Liu, Xu Tong, Qi Li, Qianqian Gan, Shipeng Ning, Meiyin Zhang
Theranostics 2026; 16(7): 3634-3647. doi:10.7150/thno.127717
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CK2-mediated HDAC5 shuttling regulates DNA end resection through Ku70 deacetylation Xueyi Liang, Jingyuan Zhao, Shoukang Li, Ruozheng Wei, Haixin Yu, Qiyue Zhang, Qixun Fu, Gengdu Qin, Yuhan Zhao, Jiaying Liu, Zhiqiang Liu, Tao Peng, Junpeng Meng, Shanmiao Gou, Tao Yin, Heshui Wu, Bo Wang, Yingke Zhou
Theranostics 2026; 16(7): 3648-3664. doi:10.7150/thno.122935
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Galectin7 attenuates abdominal aortic aneurysm progression by resisting disturbed flow induced endothelial-to-mesenchymal transition Yanbing Wang, Yilin Zhou, Yeshen Zhang, Danni Tu, Guojun Chen, Yuan Han, Xiaomin Wei, Yanmei Chen, Senlin Huang, Yulin Liao, Wangjun Liao, Jiancheng Xiu, Yuegang Wang, Jianping Bin, Xinzhong Li
Theranostics 2026; 16(7): 3665-3684. doi:10.7150/thno.117785
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Early diagnosis of colorectal cancer using Cerenkov luminescence endoscopy: a pilot trial involving humans for the first time Ze Yang, Zhuojun Wu, Tiantian Pang, Dan Liu, Xinyu Wang, Jingmin Yu, Shicheng Xu, Xiaoyu Kang, Dacheng Liao, Zuhong Tian, Yunhu Bai, Xiaojuan Xi, Tianyu Yan, Xiaojian Lu, Yu Qi, Mingru Zhang, Lina Zhao, Fei Kang, Shuhui Liang, Jing Wang, Xueli Chen, Kaichun Wu
Theranostics 2026; 16(7): 3685-3696. doi:10.7150/thno.122007
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The novel B-cell epitope peptide vaccine, MAX449, exhibits significant anti-tumor efficacy and enhances the therapeutic effects of PD-1 antibodies on tumors by modulating the activity of PMN-MDSCs Hong Yang, Xiao Han, Boshao Deng, Yunpei Zhao, Jing Zhao, Yufei Wu, Guokang Liu, Shiyu Zeng, Siyi Wang, Zhejuan Shen, Lulu Wang, Zihan Sun, Wenping Lu, Yuzhang Wu, Jian Chen
Theranostics 2026; 16(7): 3771-3789. doi:10.7150/thno.122439
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Flowerbed-inspired biomimetic 3D-printed scaffolds functionalized with urine-derived stem cell exosomes promote alveolar bone regeneration by regulating energy metabolism Yanxi Chen, Xiuyuan Yang, Yuxin Zhang, Min Yang, Hongwei Dai, Jie Li, Jianping Zhou
Theranostics 2026; 16(7): 3826-3856. doi:10.7150/thno.123700
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Percutaneous coronary intervention as an independent predictor of non-target lesion progression in 1658 patients with coronary artery disease Xiaoling Liu, Lin Chen, Chaoyu Liu, Zeyuan Mei, Jiaqi Li, Yuan Zhang, Meiling Chang, Haowei Zhang, Chenghu Guo, Mei Zhang, Guipeng An, Jianmin Yang, Wenqiang Chen, Yuzeng Xue, Cheng Zhang, Mei Ni, Yun Zhang
Theranostics 2026; 16(7): 3857-3869. doi:10.7150/thno.125363
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Pathogenomic analysis reveals clinically relevant epithelial-mesenchymal plasticity in esophageal squamous cell carcinoma Ruzhen Chen, Chenyi Xie, Ziyu Ning, Meng Yang, Zezhuo Su, Jiahui Chen, Kunheng Du, Yihuai Hu, Chu Han, Shaojun Zhang, Qingling Zhang, Meng Liu, Zaiyi Liu
Theranostics 2026; 16(7): 3870-3891. doi:10.7150/thno.125381
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Reviews
Nanomedicine in Organ Transplantation: From Graft Preservation and Repair to Immunomodulation and Monitoring Leyi Wang, Chen Jin, Junjie Zhou, Jiani Yin, Gang Xu, Zhenyu Duan, Jiayin Yang, Qiyong Gong, Kui Luo
Theranostics 2026; 16(7): 3286-3320. doi:10.7150/thno.128348
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STING signaling pathway: An oasis in the glioblastoma immune desert Yafei Wang, Weichen Duan, Chuang Yan, Xuenan Li, Rui Xing, Li Yu, Jiajia Chen
Theranostics 2026; 16(7): 3384-3407. doi:10.7150/thno.128135
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From nanotags to precision biomedicine: SERS-driven progress and innovation in tumor biomarker profiling, dynamic bioimaging, AI-enhanced diagnostics and therapy Xuelin Chen, Tenglong Liu, Weiyuan Chen, Zhexuan Lin, Qiaoxin Zhang, Binbin Zhou, Xia Zhou
Theranostics 2026; 16(7): 3447-3487. doi:10.7150/thno.126530
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Recent advances in nanoparticles targeting TGF-β signaling for cancer treatment Ziying Li, Xugang Ji, Xiaoyi Cong, Yu Gao, Jianqing Gao
Theranostics 2026; 16(7): 3507-3540. doi:10.7150/thno.126517
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Targeting efferocytosis for tissue regeneration: From microenvironment reprogramming to clinical translation Yunzhu Li, Peiyu Li, Jiayi Song, Xue Zhang, Haitao Xiao, Ru Wang, Zhenyu Duan, Kui Luo, Xuewen Xu
Theranostics 2026; 16(7): 3697-3734. doi:10.7150/thno.126081
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Contemporary opportunities and potential of Auger electron-emitting theranostics Seok-Yong Lee, H. Charles Manning
Theranostics 2026; 16(7): 3735-3770. doi:10.7150/thno.124671
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Engineering polysaccharide nanoplatforms for glioblastoma theranostics: Bridging targeted therapy and advanced imaging Xiaoming Wang, Qing Yang, Shenglan You, Lei Wu, Qiyong Gong, Yujun Zeng
Theranostics 2026; 16(7): 3790-3825. doi:10.7150/thno.123550
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Synergistic terahertz platforms for precision oncology Yan Chen, Xiaodan Kou, Jing Zou, Peng Chen, Junfeng Liu, Yanru Gu, Min Zhuang, Hongtao Xiao, Yuying Li, Man Lu, Shugang Qin
Theranostics 2026; 16(7): 3892-3911. doi:10.7150/thno.128658
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