Theranostics
2013; 3(2):93-98.
doi:10.7150/thno.5341 This issueCite
Short Research Communication
An In Vivo Evaluation of the Effect of Repeated Administration and Clearance of Targeted Contrast Agents on Molecular Imaging Signal Enhancement
Jason E. Streeter, Paul A. Dayton✉
Joint Dept. of Biomedical Engineering, University of North Carolina-North Carolina State University, Chapel Hill, NC, USA.
✉ Corresponding author: Paul A. Dayton, Address: 304 Taylor Hall, 109 Mason Farm Road, Chapel Hill, NC, 27599-6136, Phone: (919) 843-9521 Fax: (919) 843-9520, Email: padaytonunc.edu.
Citation:
Streeter JE, Dayton PA. An In Vivo Evaluation of the Effect of Repeated Administration and Clearance of Targeted Contrast Agents on Molecular Imaging Signal Enhancement. Theranostics 2013; 3(2):93-98. doi:10.7150/thno.5341. https://www.thno.org/v03p0093.htm
Competitive inhibition diminishes ligand adhesion as receptor sites become occupied with competing ligands. It is unknown if this effect occurs in ultrasound molecular imaging studies where endothelial binding sites become occupied with adherent bubbles or bubble fragments. The goal of this pilot study was to assess the effect that repeated administration and clearance of targeted agents has on successive adhesion. Two groups of animals were imaged with 3-D ultrasonic molecular imaging. Injections and imaging were performed on Group 1 at time 0 and 60 minutes. Group 2 received injections of microbubbles at 0, 15, 30, 45 and 60 minutes with imaging at 0 and 60 minutes. At 60 minutes, Group 1 targeting relative to baseline was not significantly different from Group 2 (1.06±0.27 vs. 1.08±0.34, p=0.93). Data suggest that multiple injections of targeted microbubbles do not block sufficient binding sites to bias molecular imaging data in serial studies.
Streeter, J.E., Dayton, P.A. (2013). An In Vivo Evaluation of the Effect of Repeated Administration and Clearance of Targeted Contrast Agents on Molecular Imaging Signal Enhancement. Theranostics, 3(2), 93-98. https://doi.org/10.7150/thno.5341.
ACS
Streeter, J.E.; Dayton, P.A. An In Vivo Evaluation of the Effect of Repeated Administration and Clearance of Targeted Contrast Agents on Molecular Imaging Signal Enhancement. Theranostics 2013, 3 (2), 93-98. DOI: 10.7150/thno.5341.
NLM
Streeter JE, Dayton PA. An In Vivo Evaluation of the Effect of Repeated Administration and Clearance of Targeted Contrast Agents on Molecular Imaging Signal Enhancement. Theranostics 2013; 3(2):93-98. doi:10.7150/thno.5341. https://www.thno.org/v03p0093.htm
CSE
Streeter JE, Dayton PA. 2013. An In Vivo Evaluation of the Effect of Repeated Administration and Clearance of Targeted Contrast Agents on Molecular Imaging Signal Enhancement. Theranostics. 3(2):93-98.