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Theranostics 2014; 4(1):12-23. doi:10.7150/thno.7275 This issue Cite

Research Paper

Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation

Hengte Ke², Jinrui Wang¹, Sheng Tong³, Yushen Jin², Shumin Wang¹, Enze Qu¹, Gang Bao³, Zhifei Dai^1✉

1. College of Engineering and Peking University Third Hospital, Peking University, Beijing 100871, China;
2. Nanomedicine and Biosensor Laboratory, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.
3. Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.

✉ Corresponding author: Email: zhifei.daiedu.cn.

Abstract

Imaging guided ablation therapy has been applied in both biomedical research and clinical trials and turned out to be one of the most promising approaches for cancer treatment. Herein, the multifunctional nanocapsules were fabricated through loading perfluorooctylbromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs) into poly(lactic acid) (PLA) nanocapsules (NCs), followed by the formation of PEGylated gold nanoshell on the surface. The resulting multi-component NCs were proved to be able to act as nanotheranostic agent to achieve successful bimodal ultrasound (US)/magnetic resonance imaging (MRI) guided photothermal ablation in human tumor xenograft models non-invasively. Such a single theranostic agent with the combination of real-time US and high-resolution MR imaging would be of great value to offer more comprehensive diagnostic information and dynamics of disease progression for the accurate location of therapeutic focusing spot in the targeted tumor tissue, showing great potential as an effective nanoplatform for contrast imaging guided photothermal therapy.

Keywords: Liquid perfluorocarbon nanocapules, Superparamagnetic iron oxide nanoparticles, Gold nanoshell, Bimodal imaging, Photothermal therapy.

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