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Theranostics 2017; 7(19):4763-4776. doi:10.7150/thno.21694 This issue Cite

Research Paper

Copper Manganese Sulfide Nanoplates: A New Two-Dimensional Theranostic Nanoplatform for MRI/MSOT Dual-Modal Imaging-Guided Photothermal Therapy in the Second Near-Infrared Window

Kaimei Ke¹, Wen Yang¹, Xiaoli Xie², Rui Liu², Li-Li Wang³, Wei-Wen Lin³, Guoming Huang², Chun-Hua Lu^1✉, Huang-Hao Yang^1✉

1. MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China;
2. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, P. R. China;
3. Department of Diagnostic Radiology, Union Hospital, Fujian Medical University, Fuzhou 350001, P. R. China.

✉ Corresponding authors: chunhualuedu.cn; hhyangedu.cn

Abstract

Multifunctional nanoplatforms with integrated diagnostic and therapeutic functions have attracted tremendous attention. Especially, the second near-infrared (NIR-II) light response-based nanoplatforms hold great potential in cancer theranostic applications, which is because the NIR-II window provides larger tissue penetration depth and higher maximum permissible exposure (MPE) than that of the well-studied first near-infrared (NIR-I) window. Herein, we for the first time present a two-dimensional (2D)-nanoplatform based on Cu₂MnS₂ nanoplates (NPs) for magnetic resonance imaging (MRI)/multispectral optoacoustic tomography (MSOT) dual-modal imaging-guided photothermal therapy (PTT) of cancer in the NIR-II window. Methods: Cu₂MnS₂ NPs were synthesized through a facile and environmentally friendly process. A series of experiments, including the characterization of Cu₂MnS₂ NPs, the long-term toxicity of Cu₂MnS₂ NPs in BALB/c nude mice, the applications of Cu₂MnS₂ NPs for in vitro and in vivo MRI/MSOT dual-modal imaging and NIR-II PTT of cancer were carried out. Results: The as-synthesized Cu₂MnS₂ NPs exhibit low cytotoxicity, excellent biocompatibility as well as high photothermal conversion efficiency (~49.38%) and outstanding photostability. Together with their good T₁-shortening effect and strong absorbance in the NIR-I and NIR-II region, the Cu₂MnS₂ NPs display high-contrast imaging performance both in MRI and MSOT (900 nm laser source). Moreover, the subsequent in vitro and in vivo results demonstrate that the Cu₂MnS₂ NPs possess excellent PTT efficacy under 1064 nm laser irradiation with a low power density (0.6 W cm^-2). In addition, the detailed long-term toxicity studies further confirming the safety of Cu₂MnS₂ NPs in vivo. Conclusion: We have developed a new 2D Cu₂MnS₂ NPs as multifunctional theranostic agents for MRI/MSOT dual-modal imaging-guided PTT of cancer in the NIR-II window. Such biocompatible Cu₂MnS₂ NPs might provide a new perspective for exploring new 2D-based nanoplatforms with improved properties for clinical applications in the future.

Keywords: two-dimensional nanomaterial, copper manganese sulfide nanoplates, MRI/MSOT dual-modal imaging, second near-infrared window, photothermal therapy.

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