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Theranostics 2018; 8(13):3654-3675. doi:10.7150/thno.26024 This issue Cite

Review

Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease

Bo Yu¹, Shusheng Wang^1,2✉

1. Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, 6400 Freret Street, New Orleans, LA, 70118, USA
2. Department of Ophthalmology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-69, New Orleans, LA 70112, USA

✉ Corresponding author: Shusheng Wang, PhD, Tulane University, 2000 Percival Stern Hall, 6400 Freret Street, New Orleans, Louisiana, 70118, USA. Phone: 504-862-3163; swang1edu

Abstract

Long noncoding RNAs (lncRNAs) represent a large subgroup of RNAs that are longer than 200 nucleotides and have no apparent protein coding potential. They have diverse functions in different biological processes by regulating chromatin remodeling or protein translation. This review summarizes the recent progress of lncRNAs in angiogenesis and vascular diseases. A general overview of lncRNA functional mechanisms will be introduced. A list of lncRNAs, which are termed “Angio-LncRs”, including MALAT1, MANTIS, PUNISHER, MEG3, MIAT, SENCR and GATA6-AS, will be discussed regarding their expression, regulation, function and mechanism of action in angiogenesis. Implications of lncRNAs in vascular diseases, such as atherosclerosis, hypertension, vascular retinopathies and tumor angiogenesis will also be discussed.

Keywords: Angio-LncR, lncRNA, angiogenesis, vascular disease, hypertension, atherosclerosis, retinopathy

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