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Theranostics 2020; 10(19):8591-8605. doi:10.7150/thno.45142 This issue Cite

Research Paper

Calcium Supplement by Tetracycline guided amorphous Calcium Carbonate potentiates Osteoblast promotion for Synergetic Osteoporosis Therapy

Jianwei Wang2*, Shan Tao1*, Xiangyu Jin1, Yanqing Song1, Wentao Zhou1, Haiya Lou3, Rui Zhao3, Cheng Wang1,4✉, Fuqiang Hu1, Hong Yuan1✉

1. College of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
2. The Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
3. Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 Qingchun East Road, Hangzhou, 310016, China.
4. School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, 213164, China.
*These authors contributed equally to this work.

✉ Corresponding authors: E-mails: 11519016edu.cn (C. Wang); yuanhong70edu.cn (H. Yuan).

Citation:
Wang J, Tao S, Jin X, Song Y, Zhou W, Lou H, Zhao R, Wang C, Hu F, Yuan H. Calcium Supplement by Tetracycline guided amorphous Calcium Carbonate potentiates Osteoblast promotion for Synergetic Osteoporosis Therapy. Theranostics 2020; 10(19):8591-8605. doi:10.7150/thno.45142. https://www.thno.org/v10p8591.htm
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Abstract

Graphic abstract

Background: The calcium supplement is a clinically approved approach for osteoporosis therapy but usually requires a large dosage without targetability and with poor outcome. This modality is not fully explored in current osteoporosis therapy due to the lack of proper calcium supplement carrier.

Methods: In this study, we constructed a tetracycline (Tc) modified and simvastatin (Sim) loaded phospholipid-amorphous calcium carbonate (ACC) hybrid nanoparticle (Tc/ACC/Sim).

Results: The resulted Tc/ACC/Sim was able to enhance its accumulation at the osteoporosis site. Most importantly, the combination of calcium supplement and Sim offered synergetic osteoblast promotion therapy of osteoporosis with advanced performance than non-targeted system or mono therapy.

Conclusion: This platform provides an alternative approach to stimulate bone formation by synergetic promotion of osteoblast differentiation using calcium supplement and Sim.

Keywords: calcium supplement, osteoporosis, amorphous calcium carbonate, osteoblast promotion

Citation styles

APA
Wang, J., Tao, S., Jin, X., Song, Y., Zhou, W., Lou, H., Zhao, R., Wang, C., Hu, F., Yuan, H. (2020). Calcium Supplement by Tetracycline guided amorphous Calcium Carbonate potentiates Osteoblast promotion for Synergetic Osteoporosis Therapy. Theranostics, 10(19), 8591-8605. https://doi.org/10.7150/thno.45142.

ACS
Wang, J.; Tao, S.; Jin, X.; Song, Y.; Zhou, W.; Lou, H.; Zhao, R.; Wang, C.; Hu, F.; Yuan, H. Calcium Supplement by Tetracycline guided amorphous Calcium Carbonate potentiates Osteoblast promotion for Synergetic Osteoporosis Therapy. Theranostics 2020, 10 (19), 8591-8605. DOI: 10.7150/thno.45142.

NLM
Wang J, Tao S, Jin X, Song Y, Zhou W, Lou H, Zhao R, Wang C, Hu F, Yuan H. Calcium Supplement by Tetracycline guided amorphous Calcium Carbonate potentiates Osteoblast promotion for Synergetic Osteoporosis Therapy. Theranostics 2020; 10(19):8591-8605. doi:10.7150/thno.45142. https://www.thno.org/v10p8591.htm

CSE
Wang J, Tao S, Jin X, Song Y, Zhou W, Lou H, Zhao R, Wang C, Hu F, Yuan H. 2020. Calcium Supplement by Tetracycline guided amorphous Calcium Carbonate potentiates Osteoblast promotion for Synergetic Osteoporosis Therapy. Theranostics. 10(19):8591-8605.

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