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Volume 10 (19); 2020

Research Papers

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Serum piRNA-54265 is a New Biomarker for early detection and clinical surveillance of Human Colorectal Cancer
Dongmei Mai, Yanfen Zheng, Huan Guo, Peirong Ding, Ruihong Bai, Mei Li, Ying Ye, Jialiang Zhang, Xudong Huang, Dingxin Liu, Qiaoqi Sui, Ling Pan, Jiachun Su, Junge Deng, Guandi Wu, Rui Li, Shuang Deng, Yansen Bai, Yanan Ligu, Wen Tan, Chen Wu, Tangchun Wu, Jian Zheng, Dongxin Lin
Theranostics 2020; 10(19): 8468-8478. doi:10.7150/thno.46241
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Yeast Cell wall Particle mediated Nanotube-RNA delivery system loaded with miR365 Antagomir for Post-traumatic Osteoarthritis Therapy via Oral Route
Long Zhang, Hang Peng, Wan Zhang, Yankun Li, Liang Liu, Tongtong Leng
Theranostics 2020; 10(19): 8479-8493. doi:10.7150/thno.46761
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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EZH2-mediated Epigenetic Silencing of miR-29/miR-30 targets LOXL4 and contributes to Tumorigenesis, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer
Huilong Yin, Yidi Wang, Ye Wu, Xiang Zhang, Xiaofang Zhang, Jun Liu, Ting Wang, Jing Fan, Jianyong Sun, Angang Yang, Rui Zhang
Theranostics 2020; 10(19): 8494-8512. doi:10.7150/thno.44849
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A general-purpose Nanohybrid fabricated by Polymeric Au(I)-peptide precursor to wake the function of Peptide Therapeutics
Jin Yan, Fanpu Ji, Siqi Yan, Weiming You, Fang Ma, Fanni Li, Yinong Huang, Wenjia Liu, Wangxiao He
Theranostics 2020; 10(19): 8513-8527. doi:10.7150/thno.47243
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Increased intracellular Cl- concentration improves airway epithelial migration by activating the RhoA/ROCK Pathway
Wenjie Huang, Meiling Tan, Yue Wang, Lei Liu, Yan Pan, Jingjing Li, Mingxing Ouyang, Chunjiao Long, Xiangping Qu, Huijun Liu, Chi Liu, Jia Wang, Linhong Deng, Yang Xiang, Xiaoqun Qin
Theranostics 2020; 10(19): 8528-8540. doi:10.7150/thno.46002
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis
Yang Ye, Jian He, Yue Qiao, Yuchen Qi, Hongbo Zhang, Hélder A. Santos, Danni Zhong, Wanlin Li, Shiyuan Hua, Wei Wang, Andrzej Grzybowski, Ke Yao, Min Zhou
Theranostics 2020; 10(19): 8541-8557. doi:10.7150/thno.46895
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing
De Chen, Yanjie Wang, Ruixun Lu, Xiaofeng Jiang, Xinhui Chen, Nan Meng, Min Chen, Shan Xie, Guang-Rong Yan
Theranostics 2020; 10(19): 8558-8572. doi:10.7150/thno.44873
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma
Xinxu Min, Xiaojin Zhang, Yunfan Li, Xiaofei Cao, Hao Cheng, Yuehua Li, Chuanfu Li, Qiuyue Kong, Qian Mao, Peipei Peng, Yan Ni, Jingjin Li, Yulian Duan, Li Liu, Zhengnian Ding
Theranostics 2020; 10(19): 8573-8590. doi:10.7150/thno.44321
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Calcium Supplement by Tetracycline guided amorphous Calcium Carbonate potentiates Osteoblast promotion for Synergetic Osteoporosis Therapy
Jianwei Wang, Shan Tao, Xiangyu Jin, Yanqing Song, Wentao Zhou, Haiya Lou, Rui Zhao, Cheng Wang, Fuqiang Hu, Hong Yuan
Theranostics 2020; 10(19): 8591-8605. doi:10.7150/thno.45142
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Fructose-1, 6-bisphosphatase 1 interacts with NF-κB p65 to regulate breast tumorigenesis via PIM2 induced phosphorylation
Chao Lu, Chune Ren, Tingting Yang, Yonghong Sun, Pengyun Qiao, Xue Han, Zhenhai Yu
Theranostics 2020; 10(19): 8606-8618. doi:10.7150/thno.46861
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation
Peipei Ding, Ling Li, Luying Li, Xinyue Lv, Danlei Zhou, Qingkai Wang, Jianfeng Chen, Chaoqun Yang, Enjie Xu, Weixing Dai, Xin Zhang, Na Wang, Qi Wang, Wei Zhang, Long Zhang, Yuzhen Zhou, Hongyu Gu, Qunying Lei, Xuhui Zhou, Weiguo Hu
Theranostics 2020; 10(19): 8619-8632. doi:10.7150/thno.45058
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer
Wang-Yu Cai, Zi-Nan Dong, Xiao-Teng Fu, Ling-Yun Lin, Lin Wang, Guo-Dong Ye, Qi-Cong Luo, Yu-Chao Chen
Theranostics 2020; 10(19): 8633-8647. doi:10.7150/thno.47938
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Improved cardiovascular risk prediction in patients with end-stage renal disease on hemodialysis using machine learning modeling and circulating microribonucleic acids
David de Gonzalo-Calvo, Pablo Martínez-Camblor, Christian Bär, Kevin Duarte, Nicolas Girerd, Bengt Fellström, Roland E. Schmieder, Alan G. Jardine, Ziad A. Massy, Hallvard Holdaas, Patrick Rossignol, Faiez Zannad, Thomas Thum
Theranostics 2020; 10(19): 8665-8676. doi:10.7150/thno.46123
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Spatial heterogeneity of radiolabeled choline positron emission tomography in tumors of patients with non-small cell lung cancer: first-in-patient evaluation of [18F]fluoromethyl-(1,2-2H4)-choline
Suraiya Dubash, Marianna Inglese, Francesco Mauri, Kasia Kozlowski, Pritesh Trivedi, Mubarik Arshad, Amarnath Challapalli, Tara Barwick, Adil Al-Nahhas, Rex Stanbridge, Conrad Lewanski, Matthew Berry, Frances Bowen, Eric O. Aboagye
Theranostics 2020; 10(19): 8677-8690. doi:10.7150/thno.47298
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors
Yao Tang, Yuejia Ji, Chenglin Yi, Di Cheng, Bin Wang, Yun Fu, Yufang Xu, Xuhong Qian, Yahya E. Choonara, Viness Pillay, Weiping Zhu, Yunen Liu, Zhihong Nie
Theranostics 2020; 10(19): 8691-8704. doi:10.7150/thno.45392
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Restorative functions of Autologous Stem Leydig Cell transplantation in a Testosterone-deficient non-human primate model
Kai Xia, Hong Chen, Jiancheng Wang, Xin Feng, Yong Gao, Yi Wang, Rongda Deng, Chunxing Wu, Peng Luo, Min Zhang, Chao Wang, Yong Zhang, Yadong Zhang, Guihua Liu, Xiang'an Tu, Xiangzhou Sun, Weiqiang Li, Qiong Ke, Chunhua Deng, Andy Peng Xiang
Theranostics 2020; 10(19): 8705-8720. doi:10.7150/thno.46854
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Erythropoietin receptor in B cells plays a role in bone remodeling in mice
Naamit Deshet-Unger, Albert Kolomansky, Nathalie Ben-Califa, Sahar Hiram-Bab, Dafna Gilboa, Tamar Liron, Maria Ibrahim, Zamzam Awida, Anton Gorodov, Howard S. Oster, Moshe Mittelman, Martina Rauner, Ben Wielockx, Yankel Gabet, Drorit Neumann
Theranostics 2020; 10(19): 8744-8756. doi:10.7150/thno.45845
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma
Abigail R Molloy, Chloé Najac, Pavithra Viswanath, Aliya Lakhani, Elavarasan Subramani, Georgios Batsios, Marina Radoul, Anne Marie Gillespie, Russell O Pieper, Sabrina M Ronen
Theranostics 2020; 10(19): 8757-8770. doi:10.7150/thno.47317
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A panel of eight microRNAs is a good predictive parameter for triple-negative breast cancer relapse
Hsiao-Chin Hong, Cheng-Hsun Chuang, Wei-Chih Huang, Shun-Long Weng, Chia-Hung Chen, Kuang-Hsin Chang, Kuang-Wen Liao, Hsien-Da Huang
Theranostics 2020; 10(19): 8771-8789. doi:10.7150/thno.46142
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cartilage Oligomeric Matrix Protein promotes epithelial-mesenchymal transition by interacting with Transgelin in Colorectal Cancer
Weilong Zhong, Huiqin Hou, Tianyu Liu, Shuai Su, Xiaonan Xi, Yusheng Liao, Runxiang Xie, Ge Jin, Xiang Liu, Lanping Zhu, Hongxia Zhang, Xueli Song, Cheng Yang, Tao Sun, Hailong Cao, Bangmao Wang
Theranostics 2020; 10(19): 8790-8806. doi:10.7150/thno.44456
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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House Dust Mite Specific Antibodies induce Neutrophilic Inflammation in the Heart
Xiao Chen, Yuan-Yi Zhang, Dongting Ye, Gui Yang, Yan-Nan Song, Li-Hua Mo, Ping-Chang Yang, Jiang-Ping Song
Theranostics 2020; 10(19): 8807-8817. doi:10.7150/thno.47134
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Immunomodulation of intracranial melanoma in response to blood-tumor barrier opening with focused ultrasound
Colleen T. Curley, Aaron D. Stevens, Alexander S. Mathew, Katarzyna Stasiak, William J. Garrison, G. Wilson Miller, Natasha D. Sheybani, Victor H. Engelhard, Timothy N.J. Bullock, Richard J. Price
Theranostics 2020; 10(19): 8821-8833. doi:10.7150/thno.47983
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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LXR activation potentiates sorafenib sensitivity in HCC by activating microRNA-378a transcription
Zhongjie Lin, Shunjie Xia, Yuelong Liang, Lin Ji, Yu Pan, Shi Jiang, Zhe Wan, Liye Tao, Jiang Chen, Chengping Lin, Xiao Liang, Junjie Xu, Xiujun Cai
Theranostics 2020; 10(19): 8834-8850. doi:10.7150/thno.45158
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Single-cell analysis reveals immune landscape in kidneys of patients with chronic transplant rejection
Yongguang Liu, Jianmin Hu, Ding Liu, Song Zhou, Jun Liao, Guorong Liao, Siqiang Yang, Zefeng Guo, Yuzhu Li, Shichao Li, Hua Chen, Ying Guo, Ming Li, Lipei Fan, Liuyang Li, Anqi Lin, Ming Zhao
Theranostics 2020; 10(19): 8851-8862. doi:10.7150/thno.48201
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression
Ming Li, Yuan Deng, Minghui Zhuo, Hui Zhou, Xu Kong, Xiaogang Xia, Zhaojie Su, Qiang Chen, Peng Guo, Pingli Mo, Chundong Yu, Wengang Li
Theranostics 2020; 10(19): 8863-8879. doi:10.7150/thno.45581
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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DNA methylation maintains the CLDN1-EPHB6-SLUG axis to enhance chemotherapeutic efficacy and inhibit lung cancer progression
Jia-En Wu, Yi-Ying Wu, Chia-Hao Tung, Yao-Tsung Tsai, Hsuan-Yu Chen, Yuh-Ling Chen, Tse-Ming Hong
Theranostics 2020; 10(19): 8903-8923. doi:10.7150/thno.45785
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Emerging role of exosomes in craniofacial and dental applications
Xin Xing, Shuang Han, Zhi Li, Zubing Li
Theranostics 2020; 10(19): 8648-8664. doi:10.7150/thno.48291
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Stem cell programs in cancer initiation, progression, and therapy resistance
Tianzhi Huang, Xiao Song, Dandan Xu, Deanna Tiek, Anshika Goenka, Bingli Wu, Namratha Sastry, Bo Hu, Shi-Yuan Cheng
Theranostics 2020; 10(19): 8721-8743. doi:10.7150/thno.41648
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Long non-coding RNAs in gastric cancer: New emerging biological functions and therapeutic implications
Huidan Tan, Shouyue Zhang, Jin Zhang, Lingjuan Zhu, Yanmei Chen, Hongmei Yang, Yi Chen, Yang An, Bo Liu
Theranostics 2020; 10(19): 8880-8902. doi:10.7150/thno.47548
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Erratum

Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway: Erratum
Chuan Qin, Qian Liu, Zi-Wei Hu, Luo-Qi Zhou, Ke Shang, Dale B. Bosco, Long-Jun Wu, Dai-Shi Tian, Wei Wang
Theranostics 2020; 10(19): 8818-8820. doi:10.7150/thno.49958
[Abstract] [Full text] [PDF] [PubMed] [PMC]