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Volume 10 (18); 2020

Research Papers

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Evaluation of 18F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue
François-Xavier Lepelletier, Matthias Vandesquille, Marie-Claude Asselin, Christian Prenant, Andrew C Robinson, David M A Mann, Michael Green, Elizabeth Barnett, Samuel D Banister, Marco Mottinelli, Christophe Mesangeau, Christopher R McCurdy, Inga B Fricke, Andreas H. Jacobs, Michael Kassiou, Hervé Boutin
Theranostics 2020; 10(18): 7938-7955. doi:10.7150/thno.47585
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeting the Notch and TGF-β signaling pathways to prevent retinal fibrosis in vitro and in vivo
Jiawen Fan, Weiyong Shen, So-Ra Lee, Ashish Easow Mathai, Rui Zhang, Gezhi Xu, Mark C. Gillies
Theranostics 2020; 10(18): 7956-7973. doi:10.7150/thno.45192
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC
Seong-Jin Kim, Jin-Sung Ju, Myoung-Hee Kang, Ji Eun Won, Young Ha Kim, Prahlad V Raninga, Kum Kum Khanna, Balázs Győrffy, Chan-Gi Pack, Hee-Dong Han, Hee Jin Lee, Gyungyub Gong, Yong Shin, Gordon B. Mills, Seong-il Eyun, Yun-Yong Park
Theranostics 2020; 10(18): 7974-7992. doi:10.7150/thno.45037
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Specific ablation of CD4+ T-cells promotes heart regeneration in juvenile mice
Jiatao Li, Cai Liang, Kevin Y. Yang, Xiuzhen Huang, Mao Ying Han, Xisheng Li, Vicken W. Chan, Kathleen S. Chan, Di Liu, Zhan-Peng Huang, Bin Zhou, Kathy O. Lui
Theranostics 2020; 10(18): 8018-8035. doi:10.7150/thno.42943
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin αvβ3 signaling
Jiahua Cui, Chuanjun Shu, Jin Xu, Dongyin Chen, Jin Li, Kun Ding, Minjuan Chen, Aiping Li, Jingdong He, Yongqian Shu, Liuqing Yang, Ruiwen Zhang, Jianwei Zhou
Theranostics 2020; 10(18): 8036-8050. doi:10.7150/thno.45843
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Autophagy-lysosome inhibitor chloroquine prevents CTLA-4 degradation of T cells and attenuates acute rejection in murine skin and heart transplantation
Jikai Cui, Jizhang Yu, Heng Xu, Yanqiang Zou, Hao Zhang, Shanshan Chen, Sheng Le, Jing Zhao, Lang Jiang, Jiahong Xia, Jie Wu
Theranostics 2020; 10(18): 8051-8060. doi:10.7150/thno.43507
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer
Yongqi Zhen, Rongyan Zhao, Minjuan Wang, Xing Jiang, Feng Gao, Leilei Fu, Lan Zhang, Xian-Li Zhou
Theranostics 2020; 10(18): 8080-8097. doi:10.7150/thno.43473
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mcl-1 inhibition overcomes intrinsic and acquired Regorafenib resistance in Colorectal Cancer
Xiangping Song, Lin Shen, Jingshan Tong, Chaoyuan Kuang, Shan Zeng, Robert E. Schoen, Jian Yu, Haiping Pei, Lin Zhang
Theranostics 2020; 10(18): 8098-8110. doi:10.7150/thno.45363
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Screening for in-vivo regional contractile defaults to predict the delayed Doxorubicin Cardiotoxicity in Juvenile Rat
Nourdine Chakouri, Charlotte Farah, Stefan Matecki, Pascal Amedro, Marie Vincenti, Laure Saumet, Laurence Vergely, Nicolas Sirvent, Alain Lacampagne, Olivier Cazorla
Theranostics 2020; 10(18): 8130-8142. doi:10.7150/thno.47407
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Perfusion-guided sonopermeation of neuroblastoma: a novel strategy for monitoring and predicting liposomal doxorubicin uptake in vivo
Aditi Bellary, Arelly Villarreal, Rojin Eslami, Quincy J. Undseth, Bianca Lec, Ann M. Defnet, Naina Bagrodia, Jessica J. Kandel, Mark A. Borden, Sumbul Shaikh, Rajiv Chopra, Theodore W. Laetsch, Lauren J. Delaney, Colette M. Shaw, John R. Eisenbrey, Sonia L. Hernandez, Shashank R. Sirsi
Theranostics 2020; 10(18): 8143-8161. doi:10.7150/thno.45903
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Morphological transformation enhances Tumor Retention by Regulating the Self-assembly of Doxorubicin-peptide Conjugates
Liu Xu, Yutong Wang, Chenqi Zhu, Shujing Ren, Yurou Shao, Li Wu, Weidong Li, Xiaobin Jia, Rongfeng Hu, Rui Chen, Zhipeng Chen
Theranostics 2020; 10(18): 8162-8178. doi:10.7150/thno.45088
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dissolving Microneedles with Spatiotemporally controlled pulsatile release Nanosystem for Synergistic Chemo-photothermal Therapy of Melanoma
Wanbing Qin, Guilan Quan, Ying Sun, Minglong Chen, Peipei Yang, Disang Feng, Ting Wen, Xinyu Hu, Xin Pan, Chuanbin Wu
Theranostics 2020; 10(18): 8179-8196. doi:10.7150/thno.44194
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice
Xueying Zhou, Zhelong Li, Meihao Qi, Ping Zhao, Yunyou Duan, Guodong Yang, Lijun Yuan
Theranostics 2020; 10(18): 8197-8210. doi:10.7150/thno.43968
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis
Haiou Yang, Haiyang Zhang, Yuchong Yang, Xinyi Wang, Ting Deng, Rui Liu, Tao Ning, Ming Bai, Hongli Li, Kegan Zhu, Jialu Li, Qian Fan, Guoguang Ying, Yi Ba
Theranostics 2020; 10(18): 8211-8226. doi:10.7150/thno.44419
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Self-assembling peptide hydrogels functionalized with LN- and BDNF- mimicking epitopes synergistically enhance peripheral nerve regeneration
Shuhui Yang, Chong Wang, Jinjin Zhu, Changfeng Lu, Haitao Li, Fuyu Chen, Jiaju Lu, Zhe Zhang, Xiaoqing Yan, He Zhao, Xiaodan Sun, Lingyun Zhao, Jing Liang, Yu Wang, Jiang Peng, Xiumei Wang
Theranostics 2020; 10(18): 8227-8249. doi:10.7150/thno.44276
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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pH-responsive DNA nanomicelles for chemo-gene Synergetic Therapy of Anaplastic Large Cell Lymphoma
Yuwei Li, Shuzhen Yue, Jingyu Cao, Chengzhan Zhu, Yixiu Wang, Xin Hai, Weiling Song, Sai Bi
Theranostics 2020; 10(18): 8250-8263. doi:10.7150/thno.45803
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A new class of PentixaFor- and PentixaTher-based theranostic agents with enhanced CXCR4-targeting efficiency
Theresa Osl, Alexander Schmidt, Markus Schwaiger, Margret Schottelius, Hans-Jürgen Wester
Theranostics 2020; 10(18): 8264-8280. doi:10.7150/thno.45537
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD
Lu Zhang, Linda Xiaoyan Li, Julie Xia Zhou, Peter C. Harris, James P. Calvet, Xiaogang Li
Theranostics 2020; 10(18): 8281-8297. doi:10.7150/thno.47315
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in Severe Acute Pancreatitis
Jie-Hui Tan, Rong-Chang Cao, Lei Zhou, Zhi-Tao Zhou, Huo-Ji Chen, Jia Xu, Xue-Mei Chen, Yang-Chen Jin, Jia-Yu Lin, Jun-Ling Zeng, Shu-Ji Li, Min Luo, Guo-Dong Hu, Xiao-Bing Yang, Jin Jin, Guo-Wei Zhang
Theranostics 2020; 10(18): 8298-8314. doi:10.7150/thno.46934
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Emodin reduces Breast Cancer Lung Metastasis by suppressing Macrophage-induced Breast Cancer Cell Epithelial-mesenchymal transition and Cancer Stem Cell formation
Qing Liu, Johnie Hodge, Junfeng Wang, Yuzhen Wang, Lianming Wang, Udai P. Singh, Yong Li, Yongzhong Yao, Dawei Wang, Walden Ai, Prakash Nagarkatti, Hexin Chen, Peisheng Xu, E. Angela Murphy, Daping Fan
Theranostics 2020; 10(18): 8365-8381. doi:10.7150/thno.45395
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nanomicelle protects the immune activation effects of Paclitaxel and sensitizes tumors to anti-PD-1 Immunotherapy
Qianmei Yang, Gang Shi, Xiaolei Chen, Yi Lin, Lin Cheng, Qingyuan Jiang, Xi Yan, Ming Jiang, Yiming Li, Hantao Zhang, Huiling Wang, Yuan Wang, Qingnan Wang, Yujing Zhang, Yi Liu, Xiaolan Su, Lei Dai, Minghai Tang, Jia Li, Lan Zhang, Zhiyong Qian, Dechao Yu, Hongxin Deng
Theranostics 2020; 10(18): 8382-8399. doi:10.7150/thno.45391
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer
Junfeng Zhang, Jianyu Yang, Chaoyi Lin, Wei Liu, Yanmiao Huo, Minwei Yang, Shu-Heng Jiang, Yongwei Sun, Rong Hua
Theranostics 2020; 10(18): 8400-8414. doi:10.7150/thno.45124
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity
Longze Sha, Ting Chen, Yu Deng, Tingfu Du, Kaili Ma, Wanwan Zhu, Yan Shen, Qi Xu
Theranostics 2020; 10(18): 8415-8429. doi:10.7150/thno.44721
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Modulation of the Astrocyte-Neuron Lactate Shuttle System contributes to Neuroprotective action of Fibroblast Growth Factor 21
Yan Sun, Yue Wang, Su-Ting Chen, Ying-Jie Chen, Jie Shen, Wen-Bing Yao, Xiang-Dong Gao, Song Chen
Theranostics 2020; 10(18): 8430-8445. doi:10.7150/thno.44370
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Lentivirus-mediated IL-10-expressing Bone Marrow Mesenchymal Stem Cells promote corneal allograft survival via upregulating lncRNA 003946 in a rat model of corneal allograft rejection
Xiaoxiao Lu, Yusha Ru, Chenchen Chu, Ying Lv, Yichen Gao, Zhe Jia, Yue Huang, Yan Zhang, Shaozhen Zhao
Theranostics 2020; 10(18): 8446-8467. doi:10.7150/thno.31711
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Self-eating: friend or foe? The emerging role of autophagy in fibrotic diseases
Yajing Li, Runping Liu, Jianzhi Wu, Xiaojiaoyang Li
Theranostics 2020; 10(18): 7993-8017. doi:10.7150/thno.47826
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Gold-based Inorganic Nanohybrids for Nanomedicine Applications
Xianguang Ding, Dan Li, Jiang Jiang
Theranostics 2020; 10(18): 8061-8079. doi:10.7150/thno.42284
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy
Tao-Tao Tang, Bin Wang, Lin-Li Lv, Bi-Cheng Liu
Theranostics 2020; 10(18): 8111-8129. doi:10.7150/thno.47865
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target
Jin Zhang, Honggang Xiang, Jie Liu, Yi Chen, Rong-Rong He, Bo Liu
Theranostics 2020; 10(18): 8315-8342. doi:10.7150/thno.45922
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tumor progression locus 2 (TPL2) in tumor-promoting Inflammation, Tumorigenesis and Tumor Immunity
Lucy Wanjiru Njunge, Andreanne Poppy Estania, Yao Guo, Wanqian Liu, Li Yang
Theranostics 2020; 10(18): 8343-8364. doi:10.7150/thno.45848
[Abstract] [Full text] [PDF] [PubMed] [PMC]