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Theranostics 2022; 12(6):2631-2634. doi:10.7150/thno.71399 This issue Cite

Editorial

MicroRNA loaded edible nanoparticles: an emerging personalized therapeutic approach for the treatment of obesity and metabolic disorders

F. Campolo†, G. Catanzaro†, M.A. Venneri, E. Ferretti, Z.M. Besharat✉

Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
† These authors contributed equally to this work.

✉ Corresponding author: Zein Mersini Besharat, Sapienza University, Department of Experimental Medicine, Viale Regina Elena 324, 00161 Rome, Italy. E-mail: zeinmersini.besharatit. https://orcid.org/0000-0003-0317-9854

Citation:
Campolo F, Catanzaro G, Venneri MA, Ferretti E, Besharat ZM. MicroRNA loaded edible nanoparticles: an emerging personalized therapeutic approach for the treatment of obesity and metabolic disorders. Theranostics 2022; 12(6):2631-2634. doi:10.7150/thno.71399. https://www.thno.org/v12p2631.htm
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Commentary-article in Theranostics, Volume 11, 4061

Abstract

Graphic abstract

Obesity is a metabolic chronic disease whose prevalence is strongly growing in the last years, reaching pandemic proportions. Nowadays weight loss, achieved through lifestyle changes, is the first line therapeutic objective, although great inter-individual variabilities influence response to treatment, suggesting the involvement of epigenetic factors. In this contest, there is increasing recognition of the role of small RNA molecules, particularly microRNAs in the epigenetic regulation of genes involved in adipose tissue and glucose metabolism and several microRNAs have been found to be dysregulated in obesity and metabolic diseases. The development of novel personalized therapeutic strategies using microRNAs bears promise. However, the application of naked microRNAs has been hampered by their low specificity and sensitivity. In a recent issue of Theranostics, Kumar et al. explored the possibility of microRNA delivery through ginger-derived nanoparticles (GDNPs) as an alternative therapeutic approach for obesity treatment.

The results reported by Kumar et al., addressing non-coding RNAs and edible plant derived nanoparticles, open new perspectives for the application of this innovative and safe delivery system in the clinical practice for the treatment of obesity and other metabolic disorders.

Keywords: edible nanoparticles, microRNA, exosomes, obesity, personalized medicine

Citation styles

APA
Campolo, F., Catanzaro, G., Venneri, M.A., Ferretti, E., Besharat, Z.M. (2022). MicroRNA loaded edible nanoparticles: an emerging personalized therapeutic approach for the treatment of obesity and metabolic disorders. Theranostics, 12(6), 2631-2634. https://doi.org/10.7150/thno.71399.

ACS
Campolo, F.; Catanzaro, G.; Venneri, M.A.; Ferretti, E.; Besharat, Z.M. MicroRNA loaded edible nanoparticles: an emerging personalized therapeutic approach for the treatment of obesity and metabolic disorders. Theranostics 2022, 12 (6), 2631-2634. DOI: 10.7150/thno.71399.

NLM
Campolo F, Catanzaro G, Venneri MA, Ferretti E, Besharat ZM. MicroRNA loaded edible nanoparticles: an emerging personalized therapeutic approach for the treatment of obesity and metabolic disorders. Theranostics 2022; 12(6):2631-2634. doi:10.7150/thno.71399. https://www.thno.org/v12p2631.htm

CSE
Campolo F, Catanzaro G, Venneri MA, Ferretti E, Besharat ZM. 2022. MicroRNA loaded edible nanoparticles: an emerging personalized therapeutic approach for the treatment of obesity and metabolic disorders. Theranostics. 12(6):2631-2634.

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