Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair

Liu, Yangdan; Ho, Chiakang; Wen, Dongsheng; Sun, Jiaming; Huang, Lu; Gao, Ya; Li, Qingfeng; Zhang, Yifan

doi:10.7150/thno.78016

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Theranostics 2022; 12(15):6446-6454. doi:10.7150/thno.78016 This issue Cite

Review

Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair

Yangdan Liu^*, Chiakang Ho^*, Dongsheng Wen^*, Jiaming Sun, Lu Huang, Ya Gao^✉, Qingfeng Li^✉, Yifan Zhang^✉

Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
* Yangdan Liu, Chiakang Ho and Dongsheng Wen contributed equally to this work.

Citation:

Liu Y, Ho C, Wen D, Sun J, Huang L, Gao Y, Li Q, Zhang Y. Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair. Theranostics 2022; 12(15):6446-6454. doi:10.7150/thno.78016. https://www.thno.org/v12p6446.htm

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Abstract

The skin epidermis and appendages undergo ongoing renewal throughout life. Stem cells residing in the epidermis and hair follicles are pivotal for sustaining skin homeostasis. The self-renewal ability of stem cells significantly decreases during skin aging but actively increases during wound repair. Residential stem cells reside in niches that provide spatially distinct microenvironments for stem cell maintenance and function. Cell-extracellular matrix (ECM) adhesion is essential for the establishment of niche architecture. Collagen XVII (COL17), as a transmembrane protein constituting hemidesmosomes (HDs), mediates the interactions of stem cells with surrounding cells and the matrix to regulate skin homeostasis, aging and wound repair. This review focuses on the pivotal role of the niche component COL17 in stem cell maintenance and its function in regulation of skin aging and wound repair.

Keywords: Collagen XVII, Aging, Wound repair, Stem cell, Stem cell niche

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APA

Liu, Y., Ho, C., Wen, D., Sun, J., Huang, L., Gao, Y., Li, Q., Zhang, Y. (2022). Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair. Theranostics, 12(15), 6446-6454. https://doi.org/10.7150/thno.78016.

ACS

Liu, Y.; Ho, C.; Wen, D.; Sun, J.; Huang, L.; Gao, Y.; Li, Q.; Zhang, Y. Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair. Theranostics 2022, 12 (15), 6446-6454. DOI: 10.7150/thno.78016.

NLM

CSE

Liu Y, Ho C, Wen D, Sun J, Huang L, Gao Y, Li Q, Zhang Y. 2022. Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair. Theranostics. 12(15):6446-6454.

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