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Volume 9 (21); 2019

Research Papers

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Chronic Model of Inflammatory Bowel Disease in IL-10-/- Transgenic Mice: Evaluation with Ultrasound Molecular Imaging
Huaijun Wang, Jose G Vilches-Moure, Samir Cherkaoui, Isabelle Tardy, Charline Alleaume, Thierry Bettinger, Amelie Lutz, Ramasamy Paulmurugan
Theranostics 2019; 9(21): 6031-6046. doi:10.7150/thno.37397
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53
Maximiliane Schuldner, Bastian Dörsam, Olga Shatnyeva, Katrin S. Reiners, Andriy Kubarenko, Hinrich P. Hansen, Florian Finkernagel, Katrin Roth, Sebastian Theurich, Andrea Nist, Thorsten Stiewe, Annette Paschen, Gero Knittel, Hans C. Reinhardt, Rolf Müller, Michael Hallek, Elke Pogge von Strandmann
Theranostics 2019; 9(21): 6047-6062. doi:10.7150/thno.36378
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Copy number gain of ZEB1 mediates a double-negative feedback loop with miR-33a-5p that regulates EMT and bone metastasis of prostate cancer dependent on TGF-β signaling
Yuhu Dai, Zhengquan Wu, Chuandong Lang, Xin Zhang, Shaofu He, Qing Yang, Wei Guo, Yingrong Lai, Hong Du, Xinsheng Peng, Dong Ren
Theranostics 2019; 9(21): 6063-6079. doi:10.7150/thno.36735
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Injectable hydrogels for the sustained delivery of a HER2-targeted antibody for preventing local relapse of HER2+ breast cancer after breast-conserving surgery
Xiaobin Chen, Maoli Wang, Xiaowei Yang, Yaoben Wang, Lin Yu, Jian Sun, Jiandong Ding
Theranostics 2019; 9(21): 6080-6098. doi:10.7150/thno.36514
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CRISPR-based Activation of Endogenous Neurotrophic Genes in Adipose Stem Cell Sheets to Stimulate Peripheral Nerve Regeneration
Mu-Nung Hsu, Han-Tsung Liao, Vu Anh Truong, Kai-Lun Huang, Fu-Jen Yu, Hwei-Hsien Chen, Thi Kieu Nuong Nguyen, Pavel Makarevich, Yelena Parfyonova, Yu-Chen Hu
Theranostics 2019; 9(21): 6099-6111. doi:10.7150/thno.36790
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Noninvasive application of mesenchymal stem cell spheres derived from hESC accelerates wound healing in a CXCL12-CXCR4 axis-dependent manner
Xiaoyan Wang, Bin Jiang, Huiyan Sun, Dejin Zheng, Zhenwu Zhang, Li Yan, Enqin Li, Yaojiong Wu, Ren-He Xu
Theranostics 2019; 9(21): 6112-6128. doi:10.7150/thno.32982
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Increasing the low lipid phosphate phosphatase 1 activity in breast cancer cells decreases transcription by AP-1 and expressions of matrix metalloproteinases and cyclin D1/D3
Xiaoyun Tang, Todd P.W. McMullen, David N. Brindley
Theranostics 2019; 9(21): 6129-6142. doi:10.7150/thno.37094
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Automatic Respiratory Gating Hepatic DCEUS-based Dual-phase Multi-parametric Functional Perfusion Imaging using a Derivative Principal Component Analysis
Diya Wang, Guy Cloutier, Yan Fan, Yanli Hou, Zhe Su, Qiang Su, Mingxi Wan
Theranostics 2019; 9(21): 6143-6156. doi:10.7150/thno.37284
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer
Azhar Ali, Elena Levantini, Chee Wai Fhu, Jun Ting Teo, John G. Clohessy, Julian L. Goggi, Chan-shuo Wu, Leilei Chen, Tan Min Chin, Daniel G Tenen
Theranostics 2019; 9(21): 6157-6174. doi:10.7150/thno.35805
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma
Tangliang Zhao, Yi Bao, Xinxin Gan, Jie Wang, Qiong Chen, Zhihui Dai, Bing Liu, Anbang Wang, Shuhan Sun, Fu Yang, Linhui Wang
Theranostics 2019; 9(21): 6175-6190. doi:10.7150/thno.35572
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Kidney-targeted rhein-loaded liponanoparticles for diabetic nephropathy therapy via size control and enhancement of renal cellular uptake
Guowei Wang, Qunying Li, Danfei Chen, Bihan Wu, Yulian Wu, Weijun Tong, Pintong Huang
Theranostics 2019; 9(21): 6191-6208. doi:10.7150/thno.37538
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mitochondrial membrane anchored photosensitive nano-device for lipid hydroperoxides burst and inducing ferroptosis to surmount therapy-resistant cancer
Mangmang Sang, Renjie Luo, Yidan Bai, Jun Dou, Zhongtao Zhang, Fulei Liu, Feng Feng, Jian Xu, Wenyuan Liu
Theranostics 2019; 9(21): 6209-6223. doi:10.7150/thno.36283
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice
Di Zhang, Paige Baldwin, Ana S. Leal, Sarah Carapellucci, Srinivas Sridhar, Karen T. Liby
Theranostics 2019; 9(21): 6224-6238. doi:10.7150/thno.36281
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Co-delivery of glycyrrhizin and doxorubicin by alginate nanogel particles attenuates the activation of macrophage and enhances the therapeutic efficacy for hepatocellular carcinoma
Qiang-Song Wang, Li-Na Gao, Xiao-Ning Zhu, Yan Zhang, Chuang-Nian Zhang, Dong Xu, Yuan-Lu Cui
Theranostics 2019; 9(21): 6239-6255. doi:10.7150/thno.35972
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Prostaglandin E2 induces DNA hypermethylation in gastric cancer in vitro and in vivo
Chi Chun Wong, Wei Kang, Jiaying Xu, Yun Qian, Simson Tsz Yat Luk, Huarong Chen, Weilin Li, Liuyang Zhao, Xiaoming Zhang, Phlip WY Chiu, Enders KW Ng, Jun Yu
Theranostics 2019; 9(21): 6256-6268. doi:10.7150/thno.35766
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Membrane TLR9 Positive Neutrophil Mediated MPLA Protects Against Fatal Bacterial Sepsis
Zhaogang Yang, Luowei Wang, Hongmei Yu, Ruonan Wang, Yawei Gou, MingMing Zhang, Chen Kang, Tongzheng Liu, Yu Lan, Xiaobing Wang, Jiwei Liu, Merideth A. Cooper, Xin Li, Kai Yue, Yongli Yu, Liying Wang, Betty Y.S. Kim, Wen Jiang, Wei Sun
Theranostics 2019; 9(21): 6269-6283. doi:10.7150/thno.37139
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model
Nathan McDannold, Yongzhi Zhang, Jeffrey G. Supko, Chanikarn Power, Tao Sun, Chengueng Peng, Natalia Vykhodtseva, Alexandra J Golby, David A. Reardon
Theranostics 2019; 9(21): 6284-6299. doi:10.7150/thno.35892
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface
Rongcai Lin, Cuijun Deng, Xuxiang Li, Yaqin Liu, Meng Zhang, Chen Qin, Qingqiang Yao, Liming Wang, Chengtie Wu
Theranostics 2019; 9(21): 6300-6313. doi:10.7150/thno.36120
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Biomineralization-inspired Crystallization of Manganese Oxide on Silk Fibroin Nanoparticles for in vivo MR/fluorescence Imaging-assisted Tri-modal Therapy of Cancer
Ruihao Yang, Mengmeng Hou, Ya Gao, Shiyu Lu, Lei Zhang, Zhigang Xu, Chang Ming Li, Yuejun Kang, Peng Xue
Theranostics 2019; 9(21): 6314-6333. doi:10.7150/thno.36252
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma
Jie Luo, Yuanzheng Xia, Yong Yin, Jun Luo, Mingming Liu, Hao Zhang, Chao Zhang, Yucheng Zhao, Lei Yang, Lingyi Kong
Theranostics 2019; 9(21): 6334-6353. doi:10.7150/thno.36818
[Abstract] [Full text] [PDF] [PubMed] [PMC]