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Volume 9 (20); 2019

Research Papers

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A Theranostic Cathepsin Activity-Based Probe for Noninvasive Intervention in Cardiovascular Diseases
Tommy Weiss-Sadan, Yael Ben-Nun, David Maimoun, Emmanuelle Merquiol, Ihab Abd-Elrahman, Israel Gotsman, Galia Blum
Theranostics 2019; 9(20): 5731-5738. doi:10.7150/thno.34402
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Decreased expression of mitochondrial miR-5787 contributes to chemoresistance by reprogramming glucose metabolism and inhibiting MT-CO3 translation
Weixiong Chen, Peng Wang, Yingjuan Lu, Tingting Jin, Xinyuan Lei, Mo Liu, Peilin Zhuang, Junkun Liao, Zhaoyu Lin, Bowen Li, Yu Peng, Guokai Pan, Xiaobin Lv, Hanqing Zhang, Zhanpeng Ou, Shule Xie, Xinyu Lin, Sheng Sun, Soldano Ferrone, Bakhos A. Tannous, Yi Ruan, Jinsong Li, Song Fan
Theranostics 2019; 9(20): 5739-5754. doi:10.7150/thno.37556
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Stimuli-responsive nanodrug self-assembled from amphiphilic drug-inhibitor conjugate for overcoming multidrug resistance in cancer treatment
Ping Huang, Guanchun Wang, Yue Su, Yongfeng Zhou, Wei Huang, Rong Zhang, Deyue Yan
Theranostics 2019; 9(20): 5755-5768. doi:10.7150/thno.36163
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System
Zu-Guo Zheng, Xin Zhang, Xiao-Xiao Liu, Xiu-Xiu Jin, Lunzhi Dai, Hui-Min Cheng, Dan Jing, Pyone Myat Thu, Mu Zhang, Hongyang Li, Jing Zhu, Chang Liu, Bin Xue, Yu Li, Ligong Chen, Cheng Peng, Weiliang Zhu, Lin Wang, Junli Liu, Hui-Jun Li, Ping Li, Xiaojun Xu
Theranostics 2019; 9(20): 5769-5783. doi:10.7150/thno.36505
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging
Zhongyuan Chen, Yueting Peng, Xiaoxue Xie, Yi Feng, Tingting Li, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
Theranostics 2019; 9(20): 5784-5796. doi:10.7150/thno.36545
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Glyco-Dendrimers as Intradermal Anti-Tumor Vaccine Targeting Multiple Skin DC Subsets
Sanne Duinkerken, Sophie K. Horrevorts, Hakan Kalay, Martino Ambrosini, Lisa Rutte, Tanja D. de Gruijl, Juan J. Garcia-Vallejo, Yvette van Kooyk
Theranostics 2019; 9(20): 5797-5809. doi:10.7150/thno.35059
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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TCF12 promotes the tumorigenesis and metastasis of hepatocellular carcinoma via upregulation of CXCR4 expression
Jing Yang, Lili Zhang, Zhiyuan Jiang, Chao Ge, Fangyu Zhao, Jingyi Jiang, Hua Tian, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Hong Li, Jinjun Li
Theranostics 2019; 9(20): 5810-5827. doi:10.7150/thno.34973
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Homotypic Cell Membrane-Cloaked Biomimetic Nanocarrier for the Targeted Chemotherapy of Hepatocellular Carcinoma
Xiaojun Liu, Yingxue Sun, Shushen Xu, Xiaonan Gao, Fanpeng Kong, Kehua Xu, Bo Tang
Theranostics 2019; 9(20): 5828-5838. doi:10.7150/thno.34837
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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N-acetyl cysteine-loaded graphene oxide-collagen hybrid membrane for scarless wound healing
Jialun Li, Chuchao Zhou, Chao Luo, Bei Qian, Shaokai Liu, Yuyang Zeng, Jinfei Hou, Bin Deng, Yang Sun, Jie Yang, Quan Yuan, Aimei Zhong, Jiecong Wang, Jiaming Sun, Zhenxing Wang
Theranostics 2019; 9(20): 5839-5853. doi:10.7150/thno.34480
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Comparison of cerebral and cutaneous microvascular dysfunction with the development of type 1 diabetes
Wei Feng, Shaojun Liu, Chao Zhang, Qing Xia, Tingting Yu, Dan Zhu
Theranostics 2019; 9(20): 5854-5868. doi:10.7150/thno.33738
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Visualization and quantification of in vivo homing kinetics of myeloid-derived suppressor cells in primary and metastatic cancer
Sabrina H. L. Hoffmann, Dorothea I. Reck, Andreas Maurer, Birgit Fehrenbacher, Jaclyn E. Sceneay, Marilena Poxleitner, Hasan H. Öz, Walter Ehrlichmann, Gerald Reischl, Kerstin Fuchs, Martin Schaller, Dominik Hartl, Manfred Kneilling, Andreas Möller, Bernd J. Pichler, Christoph M. Griessinger
Theranostics 2019; 9(20): 5869-5885. doi:10.7150/thno.33275
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Co-delivery of VEGF siRNA and Etoposide for Enhanced Anti-angiogenesis and Anti-proliferation Effect via Multi-functional Nanoparticles for Orthotopic Non-Small Cell Lung Cancer Treatment
Fang Li, Yu Wang, Wei-liang Chen, Dan-dan Wang, Ye-juan Zhou, Ben-gang You, Yang Liu, Chen-xi Qu, Shu-di Yang, Meng-tian Chen, Xue-nong Zhang
Theranostics 2019; 9(20): 5886-5898. doi:10.7150/thno.32416
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Non-invasive In Vivo Imaging of Cancer Using Surface-Enhanced Spatially Offset Raman Spectroscopy (SESORS)
Fay Nicolson, Bohdan Andreiuk, Chrysafis Andreou, Hsiao-Ting Hsu, Scott Rudder, Moritz F. Kircher
Theranostics 2019; 9(20): 5899-5913. doi:10.7150/thno.36321
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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An all-in-one homogeneous DNA walking nanomachine and its application for intracellular analysis of miRNA
Muren Hu, Dongsheng Mao, Xiaohao Liu, Lingjie Ren, Mengru Zhou, Xiaoxia Chen, Xiaoli Zhu
Theranostics 2019; 9(20): 5914-5923. doi:10.7150/thno.36081
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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TRAIL acts synergistically with iron oxide nanocluster-mediated magneto- and photothermia
Hanene Belkahla, Eva Mazarío, Anouchka Plan Sangnier, John S. Lomas, Tijani Gharbi, Souad Ammar, Olivier Micheau, Claire Wilhelm, Miryana Hémadi
Theranostics 2019; 9(20): 5924-5936. doi:10.7150/thno.36320
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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GPR124 facilitates pericyte polarization and migration by regulating the formation of filopodia during ischemic injury
Dan-Yang Chen, Ning-He Sun, Ya-Ping Lu, Ling-Juan Hong, Tian-Tian Cui, Cheng-Kun Wang, Xing-Hui Chen, Shuai-Shuai Wang, Li-Li Feng, Wei-Xing Shi, Kohji Fukunaga, Zhong Chen, Ying-Mei Lu, Feng Han
Theranostics 2019; 9(20): 5937-5955. doi:10.7150/thno.34168
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice
Panpan Xian, Yue Hei, Rui Wang, Tian Wang, Junle Yang, Jianying Li, Zhengli Di, Zhiqin Liu, Andrius Baskys, Weiping Liu, Shengxi Wu, Qianfa Long
Theranostics 2019; 9(20): 5956-5975. doi:10.7150/thno.33872
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Galectin 3 protects from cisplatin-induced acute kidney injury by promoting TLR-2-dependent activation of IDO1/Kynurenine pathway in renal DCs
Vladislav Volarevic, Bojana Simovic Markovic, Marina Gazdic Jankovic, Bojana Djokovic, Nemanja Jovicic, C. Randall Harrell, Crissy Fellabaum, Valentin Djonov, Nebojsa Arsenijevic, Miodrag L. Lukic
Theranostics 2019; 9(20): 5976-6001. doi:10.7150/thno.33959
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Biodegradable, pH-Sensitive Hollow Mesoporous Organosilica Nanoparticle (HMON) with Controlled Release of Pirfenidone and Ultrasound-Target-Microbubble-Destruction (UTMD) for Pancreatic Cancer Treatment
Feng Gao, Jianrong Wu, Shiwei Niu, Ting Sun, Fan Li, Yun Bai, Lifang Jin, Lizhou Lin, Qiusheng Shi, Li-Min Zhu, Lianfang Du
Theranostics 2019; 9(20): 6002-6018. doi:10.7150/thno.36135
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MTBP regulates cell survival and therapeutic sensitivity in TP53 wildtype glioblastomas
Yifu Song, Li Zhang, Yang Jiang, Tianhao Hu, Di Zhang, Qiao Qiao, Run Wang, Minghao Wang, Sheng Han
Theranostics 2019; 9(20): 6019-6030. doi:10.7150/thno.35747
[Abstract] [Full text] [PDF] [PubMed] [PMC]