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Volume 9 (19); 2019

Research Papers

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Intelligent gold nanostars for in vivo CT imaging and catalase-enhanced synergistic photodynamic & photothermal tumor therapy
Lin Zhang, Xiao-Quan Yang, Jian-Shuang Wei, Xing Li, Huan Wang, Yuan-Di Zhao
Theranostics 2019; 9(19): 5424-5442. doi:10.7150/thno.33015
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells
Verena Trümper, Andreas von Knethen, Annegret Preuß, Eugeny Ermilov, Steffen Hackbarth, Laura Kuchler, Sandra Gunne, Anne Schäfer, Tobias Bornhütter, György Vereb, Lázló Ujlaky-Nagy, Bernhard Brüne, Beate Röder, Michael Schindler, Michael J. Parnham, Tilo Knape
Theranostics 2019; 9(19): 5444-5463. doi:10.7150/thno.29367
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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KLF5 downregulation desensitizes castration-resistant prostate cancer cells to docetaxel by increasing BECN1 expression and inducing cell autophagy
Jing Jia, Hai-Bao Zhang, Qi Shi, Chao Yang, Jian-Bin Ma, Bin Jin, Xinyang Wang, Dalin He, Peng Guo
Theranostics 2019; 9(19): 5464-5477. doi:10.7150/thno.33282
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Multi-omics profiling reveals key signaling pathways in ovarian cancer controlled by STAT3
Tiangong Lu, Armand Bankhead, Mats Ljungman, Nouri Neamati
Theranostics 2019; 9(19): 5478-5496. doi:10.7150/thno.33444
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The miR-26a/AP-2α/Nanog signaling axis mediates stem cell self-renewal and temozolomide resistance in glioma
Wenhuan Huang, Zhe Zhong, Chang Luo, Yuzhong Xiao, Limin Li, Xing Zhang, Liu Yang, Kai Xiao, Yichong Ning, Li Chen, Qing Liu, Xiang Hu, Jian Zhang, Xiaofeng Ding, Shuanglin Xiang
Theranostics 2019; 9(19): 5497-5516. doi:10.7150/thno.33800
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Focused ultrasound activates voltage-gated calcium channels through depolarizing TRPC1 sodium currents in kidney and skeletal muscle
Scott R. Burks, Rebecca M. Lorsung, Matthew E. Nagle, Tsang-Wei Tu, Joseph A. Frank
Theranostics 2019; 9(19): 5517-5531. doi:10.7150/thno.33876
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tumor-derived DNA from pleural effusion supernatant as a promising alternative to tumor tissue in genomic profiling of advanced lung cancer
Lin Tong, Ning Ding, Xiaoling Tong, Jiamin Li, Yong Zhang, Xiaodan Wang, Xiaobo Xu, Maosong Ye, Chun Li, Xue Wu, Hairong Bao, Xin Zhang, Qunying Hong, Yuanlin Song, Yang W. Shao, Chunxue Bai, Jian Zhou, Jie Hu
Theranostics 2019; 9(19): 5532-5541. doi:10.7150/thno.34070
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor
Zeqian Huang, Gaofei Wei, Zishan Zeng, Yanjuan Huang, Liangfeng Huang, Yifeng Shen, Xiaoqi Sun, Congjun Xu, Chunshun Zhao
Theranostics 2019; 9(19): 5542-5557. doi:10.7150/thno.35343
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis
Xiang He, Shifei Wang, Mengsha Li, Lintao Zhong, Hao Zheng, Yili Sun, Yanxian Lai, Xiaoqiang Chen, Guoquan Wei, Xiaoyun Si, Yuan Han, Senlin Huang, Xinzhong Li, Wangjun Liao, Yulin Liao, Jianping Bin
Theranostics 2019; 9(19): 5558-5576. doi:10.7150/thno.34463
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal Cancer
Jing Zhou, Lu Zhang, Meng Wang, Li Zhou, Xuping Feng, Linli Yu, Jiang Lan, Wei Gao, Chundong Zhang, Youquan Bu, Canhua Huang, Haiyuan Zhang, Yunlong Lei
Theranostics 2019; 9(19): 5577-5594. doi:10.7150/thno.34663
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Ultrasound-mediated cavitation enhances the delivery of an EGFR-targeting liposomal formulation designed for chemo-radionuclide therapy
Eloise Thomas, Jyothi U. Menon, Joshua Owen, Irini Skaripa-Koukelli, Sheena Wallington, Michael Gray, Christophoros Mannaris, Veerle Kersemans, Danny Allen, Paul Kinchesh, Sean Smart, Robert Carlisle, Katherine A. Vallis
Theranostics 2019; 9(19): 5595-5609. doi:10.7150/thno.34669
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dual-Targeted Gold Nanoprism for Recognition of Early Apoptosis, Dual-Model Imaging and Precise Cancer Photothermal Therapy
Weiwei Zhang, Xiaoyuan Ding, Hao Cheng, Chenyang Yin, Jing Yan, Zhipeng Mou, Weiyun Wang, Danxi Cui, Cundong Fan, Dongdong Sun
Theranostics 2019; 9(19): 5610-5625. doi:10.7150/thno.34755
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Evaluation of novel formulations for transarterial chemoembolization: combining elements of Lipiodol emulsions with Drug-eluting Beads
Marcus Caine, Ting Chung, Hugh Kilpatrick, Zainab Bascal, Sean Willis, Yiqing Tang, Thierry de Baere, Matthew Dreher, Andrew Lewis
Theranostics 2019; 9(19): 5626-5641. doi:10.7150/thno.34778
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Chronic myelogenous leukemia cells remodel the bone marrow niche via exosome-mediated transfer of miR-320
Xiaotong Gao, Zhuo Wan, Mengying Wei, Yan Dong, Yingxin Zhao, Xutao Chen, Zhelong Li, Weiwei Qin, Guodong Yang, Li Liu
Theranostics 2019; 9(19): 5642-5656. doi:10.7150/thno.34813
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Extracellular vesicles expressing a single-chain variable fragment of an HIV-1 specific antibody selectively target Env+ tissues
Xue Zou, Meng Yuan, Tongyu Zhang, Hongxia Wei, Shijie Xu, Na Jiang, Nan Zheng, Zhiwei Wu
Theranostics 2019; 9(19): 5657-5671. doi:10.7150/thno.33925
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Visualizing Autophagic Flux during Endothelial Injury with a Pathway-Inspired Tandem-Reaction Based Fluorogenic Probe
Yu Lei, Wenming Ren, Cheng-Kun Wang, Rong-Rong Tao, Huai-Jiang Xiang, Li-Li Feng, Yin-Ping Gao, Quan Jiang, Xin Li, Youhong Hu, Feng Han
Theranostics 2019; 9(19): 5672-5680. doi:10.7150/thno.33867
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Heterologous and cross-species tropism of cancer-derived extracellular vesicles
Mariangela Garofalo, Alessandro Villa, Daniela Crescenti, Monica Marzagalli, Lukasz Kuryk, Patrizia Limonta, Vincenzo Mazzaferro, Paolo Ciana
Theranostics 2019; 9(19): 5681-5693. doi:10.7150/thno.34824
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Excretable IR-820 for in vivo NIR-II fluorescence cerebrovascular imaging and photothermal therapy of subcutaneous tumor
Zhe Feng, Xiaoming Yu, Minxiao Jiang, Liang Zhu, Yi Zhang, Wei Yang, Wang Xi, Gonghui Li, Jun Qian
Theranostics 2019; 9(19): 5706-5719. doi:10.7150/thno.31332
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction
Melanie Villanueva, Connor Michie, Sandrine Parent, Georges N Kanaan, Ghazaleh Rafatian, Pushpinder Kanda, Bin Ye, Wenbin Liang, Mary-Ellen Harper, Darryl R Davis
Theranostics 2019; 9(19): 5720-5730. doi:10.7150/thno.36639
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease
Dong Hun Lee, Tae Min Kim, Joo Kyung Kim, Changwon Park
Theranostics 2019; 9(19): 5694-5705. doi:10.7150/thno.35300
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Erratum

Negative regulation of cationic nanoparticle-induced inflammatory toxicity through the increased production of prostaglandin E2 via mitochondrial DNA-activated Ly6C+ monocytes: Erratum
Li Liu, Yantong Liu, Bocheng Xu, Chuyu Liu, Yanpeng Jia, Ting Liu, Chunju Fang, Wei Wang, Jun Ren, Zhiyao He, Ke Men, Xiao Liang, Min Luo, Bin Shao, Ye Mao, Henyi Xiao, Zhiyong Qian, Jia Geng, Birong Dong, Peng Mi, Yu Jiang, Yuquan Wei, Xiawei Wei
Theranostics 2019; 9(19): 5443. doi:10.7150/thno.37524
[Abstract] [Full text] [PDF] [PubMed] [PMC]