Theranostics 2017; 7(7):2003-2014. doi:10.7150/thno.19404 This issue Cite

Research Paper

Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents

Zhipeng Chen1,2,4*, Lei Xing3*, Qin Fan1,2*, Andrew G. Cheetham4, Ran Lin4, Barbara Holt4, Liwen Chen4, Yanyu Xiao3✉, Honggang Cui4,5,6✉

1. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China;
2. Department of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;
3. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China;
4. Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA;
5. Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;
6. Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.
* These authors contributed equally to this work

Citation:
Chen Z, Xing L, Fan Q, Cheetham AG, Lin R, Holt B, Chen L, Xiao Y, Cui H. Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents. Theranostics 2017; 7(7):2003-2014. doi:10.7150/thno.19404. https://www.thno.org/v07p2003.htm
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Abstract

Graphic abstract

We report here on the covalent conversion of the anti-inflammatory agent ketoprofen into self-assembling prodrugs that enable the effective purification of ketoprofen enantiomers, the improved selectivity and potency of ketoprofen, as well as the formation of one-component drug-bearing supramolecular hydrogels. We found that the ketoprofen hydrogelator could exhibit much-enhanced selectivity for cyclooxygenase 2 (COX-2) over COX-1, reduce the concentration of inflammatory cytokines (IL-1 and TNFα), and induce apoptosis in fibroblast-like synoviocytes while maintaining biocompatibility with healthy chondrocytes. In addition, these anti-inflammatory agent-containing hydrogels demonstrated the ability to retain the therapeutic within a joint cavity after intra-articular injection, exhibiting a slow, steady release into the plasma. We believe that upon further optimization these drug-based injectable supramolecular hydrogels could provide the basis for a local treatment strategy for rheumatoid arthritis and similar conditions.

Keywords: supramolecular hydrogel, self-assembly, drug delivery, peptide-drug conjugate, rheumatoid arthritis.


Citation styles

APA
Chen, Z., Xing, L., Fan, Q., Cheetham, A.G., Lin, R., Holt, B., Chen, L., Xiao, Y., Cui, H. (2017). Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents. Theranostics, 7(7), 2003-2014. https://doi.org/10.7150/thno.19404.

ACS
Chen, Z.; Xing, L.; Fan, Q.; Cheetham, A.G.; Lin, R.; Holt, B.; Chen, L.; Xiao, Y.; Cui, H. Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents. Theranostics 2017, 7 (7), 2003-2014. DOI: 10.7150/thno.19404.

NLM
Chen Z, Xing L, Fan Q, Cheetham AG, Lin R, Holt B, Chen L, Xiao Y, Cui H. Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents. Theranostics 2017; 7(7):2003-2014. doi:10.7150/thno.19404. https://www.thno.org/v07p2003.htm

CSE
Chen Z, Xing L, Fan Q, Cheetham AG, Lin R, Holt B, Chen L, Xiao Y, Cui H. 2017. Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents. Theranostics. 7(7):2003-2014.

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